Results 161 to 170 of about 140,109 (356)

Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons

Journal of Pharmacological Sciences, 2010
We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor
Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izumi, Tetsuhiro Niidome, Takeshi Fujii, Hachiro Sugimoto, Akinori Akaike   +6 more
doaj  

Inside‐Out IP3‐Mediated G Protein‐Coupled Receptor Activation Drives Intercellular Ca2+ Signaling in the Vascular Endothelium

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
During endothelial cell Ca2+ wave propagation, IP3 in the initiating cell activates IP3Rs on the endoplasmic reticulum, releasing Ca2+ into the cytoplasm. We show that IP3 is required for signal propagation to neighboring cells and propose that this is due to activation of membrane‐bound pore‐dead IP3Rs, as part of a noncanonical signaling inside‐out ...
C. Buckley, X. Zhang, M. D. Lee, C. Wilson, J. G. McCarron   +4 more
wiley   +1 more source

NICOTINIC ACETYLCHOLINE RECEPTORS SUBSERVING NOCICEPTION IN THE DOG HINDLIMB

, 1970
Norio Taira, Koichi Nakayama, Koroku Hashimoto   +2 more
openalex   +2 more sources

Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients. [PDF]

, 1988
Arthur Melms, Berthold Schalke, T Kirchner, H. K. Müller-Hermelink, E. D. Albert, Hartmut Wekerle   +5 more
openalex   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, Volume 15, Issue 7, Page 1041-1053, July 2025.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Studies on nicotinic acetylcholine receptors in mammalian brain. Interaction of solubilized protein with cholinergic ligands.

, 1978
Carole H. McQuarrie, Paul M. Salvaterra, H.R. Mahlers   +2 more
openalex   +1 more source

Autoimmune T lymphocytes in myasthenia gravis. Determination of target epitopes using T lines and recombinant products of the mouse nicotinic acetylcholine receptor gene. [PDF]

, 1989
Arthur Melms, Susanne Chrestel, Berthold Schalke, Hartmut Wekerle, Alex Mauron, Marc Ballivet, T. Barkas   +6 more
openalex   +1 more source

Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain

Proceedings of the National Academy of Sciences of the United States of America, 2017
Haylie K. Romero, Sean B. Christensen, L. di Cesare Mannelli, J. Gajewiak, Renuka Ramachandra, K. Elmslie, D. Vetter, C. Ghelardini, Shawn P. Iadonato, J. Mercado, B. Olivera, J. McIntosh   +11 more
semanticscholar   +1 more source

In Vivo Cytosolic Delivery of Biomolecules into Neurons for Super‐Resolution Imaging and Genome Modification

Advanced Science, Volume 12, Issue 25, July 3, 2025.
The N1 peptide specifically targets neurons, enabling cytosolic delivery of fluorescent dyes and proteins for super‐resolution imaging and functional genetic modification. Abstract Efficient delivery of biomolecules into neurons has significant impacts on therapeutic applications in the central nervous system (CNS) and fundamental neuroscience research.
Xiaoqian Ge, Joseph B. Wekselblatt, Scott Elmore, Bo Wang, Tongtong Wang, Renjinming Dai, Tingting Zhang, Harsh Dave, Mohammadaref Ghaderi, Athul Raj Anilkumar, Bill Wang, Shashank R. Sirsi, Jung‐Mo Ahn, Mikhail G. Shapiro, Yuki Oka, Carlos Lois, Zhenpeng Qin   +16 more
wiley   +1 more source

Exploring the potential of Lavandula stoechas in smoking cessation: A molecular docking study of α4β2 nicotinic acetylcholine receptor interactions

İstanbul Journal of Pharmacy
Background: Lavandula stoechas, commonly known as lavender, has traditionally been used in various therapeutic applications, including smoking cessation.
Elif Barış, Hüseyin Saygın Portakal
doaj   +1 more source