Results 171 to 180 of about 141,837 (296)

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

open access: yesChemistry – A European Journal, Volume 31, Issue 67, December 1, 2025.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju   +4 more
wiley   +1 more source

Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice

open access: yesNature Communications
Epilepsy is a prevalent disorder involving neuronal network hyperexcitability, yet existing therapeutic strategies often fail to provide optimal patient outcomes. Chemogenetic approaches, where exogenous receptors are expressed in defined brain areas and
Quynh-Anh Nguyen   +13 more
doaj   +1 more source

Cellular Communication Networks Mediated by Microglia in Ischemic Stroke

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
After ischemic stroke, microglia serve as central regulators within the neuroimmune network, engaging in dynamic crosstalk with neurons, astrocytes, vascular endothelial cells, and peripheral immune cells. By releasing cytokines, chemokines, extracellular vesicles, and transmitting mechanical signals, activated microglia coordinate inflammatory ...
Feiyu Ma   +5 more
wiley   +1 more source

Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors

open access: yesAnais da Academia Brasileira de Ciências, 2002
Several neurotransmitter systems have been related to developmental processes during the past decade. In this review, we discuss the evidence that the nicotinic acetylcholine receptors could have an additional function during development that may be ...
TORRÃO ANDRÉA S., BRITTO LUIZ R.G.
doaj  

Differential Effects of Quercetin and Quercetin Glycosides on Human α7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents

open access: green, 2016
Byunghwan Lee   +10 more
openalex   +2 more sources

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi   +3 more
wiley   +1 more source

Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation

open access: green, 2018
Marta Quadri   +7 more
openalex   +2 more sources

Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors

open access: yesPharmacological Reviews, 2015
D. Bertrand   +4 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy