Results 21 to 30 of about 42,486 (297)

Functional and structural markers of peripheral microvascular autonomic neuropathy

Muscle &Nerve, Volume 67, Issue 2, Page 146-153, February 2023., 2023
Abstract Introduction/Aims Autonomic dysfunction is a common complication of small‐fiber neuropathy (SFN). In this study we aimed to assess the applicability of autonomic microvascular indices as a potential marker for SFN assessment. Methods Fifteen patients with confirmed SFN (idiopathic neuropathy [n = 10], chemotherapy‐induced peripheral neuropathy
Thorsten K. Rasmussen, Páll Karlsson, Nanna B. Finnerup, Troels S. Jensen, Jens R. Nyengaard, Astrid J. Terkelsen   +5 more
wiley   +1 more source

Activation of a nicotinic acetylcholine receptor

Biophysical Journal, 1984
We studied activation of the nicotinic acetylcholine (ACh) receptor on cells of a mouse clonal muscle cell line (BC3H1). We analyzed single-channel currents through outside-out patches elicited with various concentrations of acetylcholine (ACh), carbamylcholine (Carb) and suberyldicholine (Sub).
Joe Henry Steinbach, Steven M. Sine
openaire   +2 more sources

Proteomic profiling of impaired excitation–contraction coupling and abnormal calcium handling in muscular dystrophy

PROTEOMICS, Volume 22, Issue 23-24, December 2022., 2022
Abstract The X‐linked inherited neuromuscular disorder Duchenne muscular dystrophy is characterised by primary abnormalities in the membrane cytoskeletal component dystrophin. The almost complete absence of the Dp427‐M isoform of dystrophin in skeletal muscles renders contractile fibres more susceptible to progressive degeneration and a leaky ...
Paul Dowling, Stephen Gargan, Dieter Swandulla, Kay Ohlendieck   +3 more
wiley   +1 more source

Characterization of nAChRs in Nematostella vectensis supports neuronal and non-neuronal roles in the cnidarian–bilaterian common ancestor

EvoDevo, 2019
Background Nicotinic and muscarinic acetylcholine receptors likely evolved in the cnidarian–bilaterian common ancestor. Both receptor families are best known for their role at chemical synapses in bilaterian animals, but they also have described roles as
Dylan Z. Faltine-Gonzalez, Michael J. Layden   +1 more
doaj   +1 more source

Toxic Effect of Cigarette Smoke on Brainstem Nicotinic Receptor Expression: Primary Cause of Sudden Unexplained Perinatal Death

Toxics, 2018
Among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic ...
Anna Maria Lavezzi
doaj   +1 more source

Palmitoylation of Nicotinic Acetylcholine Receptors [PDF]

Journal of Molecular Neuroscience, 2009
It is well established that nicotinic acetylcholine receptors (nAChRs) undergo a number of different posttranslational modifications, such as disulfide bond formation, glycosylation, and phosphorylation. Recently, our laboratory has developed more sensitive assays of protein palmitoylation that have allowed us and others to detect the palmitoylation of
M. P. Blanton, John K. Alexander, Anitha P. Govind, Renaldo C. Drisdel, William N. Green, TuKiet T. Lam, Yolanda F. Vallejo   +6 more
openaire   +3 more sources

A review of frequently used Kampo prescriptions part 1. Daikenchuto

Traditional &Kampo Medicine, Volume 9, Issue 3, Page 151-179, December 2022., 2022
Abstract Background The original formula name for daikenchuto (DKT) was written in ‘Jin Gui Yao Lue (Kinkiyōryaku in Japanese)’. DKT as used in Japan consists of four types of crude drug. Key findings Although there are few examples of its use in Chinese classical records, it has begun to be used extensively in modern Japan for intestinal obstruction ...
Takao Namiki, Takayuki Hoshino, Nobuaki Egashira, Toshiaki Kogure, Mari Endo, Masato Homma   +5 more
wiley   +1 more source

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source

Resolution of complex fluorescence spectra of lipids and nicotinic acetylcholine receptor by multivariate analysis reveals protein-mediated effects on the receptor's immediate lipid microenvironment [PDF]

PMC Biophysics 2008, 1:6, 2009
Analysis of fluorescent spectra from complex biological systems containing various fluorescent probes with overlapping emission bands is a challenging task. Valuable information can be extracted from the full spectra, however, by using multivariate analysis (MA) of measurements at different wavelengths.
arxiv   +1 more source

Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy

WIREs Nanomedicine and Nanobiotechnology, Volume 15, Issue 1, January/February 2023., 2023
Fundamental research on EV isolation, standardization and characterisation will bring about translational medical diagnostics and therapy. Abstract Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer nanoparticles secreted by most cells.
Karina P. De Sousa, Izadora Rossi, Mahamed Abdullahi, Marcel Ivan Ramirez, Dan Stratton, Jameel Malhador Inal   +5 more
wiley   +1 more source