Results 21 to 30 of about 43,248 (261)

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source

Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2.

PLoS ONE, 2014
Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis
Catherine A Vulfius, Igor E Kasheverov, Vladislav G Starkov, Alexey V Osipov, Tatyana V Andreeva, Sergey Yu Filkin, Elena V Gorbacheva, Maxim E Astashev, Victor I Tsetlin, Yuri N Utkin   +9 more
doaj   +1 more source

The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia. [PDF]

PLoS ONE, 2016
The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-1-yl)
Linda J Bristow, Amy E Easton, Yu-Wen Li, Digavalli V Sivarao, Regina Lidge, Kelli M Jones, Debra Post-Munson, Christopher Daly, Nicholas J Lodge, Lizbeth Gallagher, Thaddeus Molski, Richard Pieschl, Ping Chen, Adam Hendricson, Ryan Westphal, James Cook, Christiana Iwuagwu, Daniel Morgan, Yulia Benitex, Dalton King, John E Macor, Robert Zaczek, Richard Olson   +22 more
doaj   +1 more source

Palmitoylation of Nicotinic Acetylcholine Receptors [PDF]

Journal of Molecular Neuroscience, 2009
It is well established that nicotinic acetylcholine receptors (nAChRs) undergo a number of different posttranslational modifications, such as disulfide bond formation, glycosylation, and phosphorylation. Recently, our laboratory has developed more sensitive assays of protein palmitoylation that have allowed us and others to detect the palmitoylation of
J K, Alexander, A P, Govind, R C, Drisdel, M P, Blanton, Y, Vallejo, T T, Lam, W N, Green   +6 more
openaire   +2 more sources

Concomitant release of ventral tegmental acetylcholine and accumbal dopamine by ghrelin in rats. [PDF]

PLoS ONE, 2012
Ghrelin, an orexigenic peptide, regulates energy balance specifically via hypothalamic circuits. Growing evidence suggest that ghrelin increases the incentive value of motivated behaviours via activation of the cholinergic-dopaminergic reward link.
Elisabet Jerlhag, Anna Carin Janson, Susanna Waters, Jörgen A Engel   +3 more
doaj   +1 more source

Acetylcholine induces stem cell properties of gastric cancer cells of diffuse type

Tumor Biology, 2018
Gastric cancer is the third leading cause of cancer-related death worldwide, but the mechanisms of gastric carcinogenesis are not completely understood.
Phu Hung Nguyen, Yann Touchefeu, Tony Durand, Philippe Aubert, Emilie Duchalais, Stanislas Bruley des Varannes, Christine Varon, Michel Neunlist, Tamara Matysiak-Budnik   +8 more
doaj   +1 more source

Chaperoning α7 neuronal nicotinic acetylcholine receptors [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
The α7 subtype of nicotinic acetylcholine receptors (AChRs) is one of the most abundant members of the Cys-loop family of receptors present in the central nervous system. It participates in various physiological processes and has received much attention as a potential therapeutic target for a variety of pathologies.
Valles, Ana Sofia, Barrantes, Francisco Jose   +1 more
openaire   +4 more sources

New insight into the tick neuronal nicotinic acetylcholine receptors: from molecular to pharmacological studies

Ticks and Tick-Borne Diseases
ACh is known to be an excitatory neurotransmitter in the central nervous system of several arthropod species. Nicotinic acetylcholine receptors are involved in rapid neurotransmission and are the target of compounds used as acaricides.
Khalid Boussaine, Philippine Chartier, Alison Cartereau, Daniel Auguin, Emiliane Taillebois, Steeve H. Thany   +5 more
doaj   +1 more source

Silent agonists for α7 nicotinic acetylcholine receptors

Pharmacological Research, 2023
We discuss models for the activation and desensitization of α7 nicotinic acetylcholine receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators (PAMs) that destabilize α7 desensitized states.
Roger L. Papke, Marta Quadri, Alican Gulsevin   +2 more
doaj   +1 more source

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines. [PDF]

PLoS ONE, 2015
Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which depends on the specific ...
Avi Ring, Bjorn Oddvar Strom, Simon R Turner, Christopher M Timperley, Michael Bird, A Christopher Green, John E Chad, Franz Worek, John E H Tattersall   +8 more
doaj   +1 more source