Results 41 to 50 of about 2,587,321 (283)
FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich +19 more
wiley +1 more source
Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers
ADMET and DMPK, 2019 The paper is devoted to the study of the ion exchange encapsulation of nicotinic acid in nanocontainers on polymer matrices. Dowex-50 cation exchanger, sulphonated polymer based on metacyclophanoctol, polymer zirconium phosphate, and strongly basic Dowex-
Heinrich Altshuler +6 more
doaj +1 more source
Changes in conformation and subcellular distribution of alpha(4)beta(2) nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras [PDF]
, 2002 Chronic exposure to nicotine, as occurs during tobacco smoking, is one of several factors that have been reported to cause an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs).
Harkness, PC, Millar, NS
core
Charting Morphotoxicity With Complementary Embryo Models
Advanced Healthcare Materials, EarlyView.Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx +9 more
wiley +1 more source
, 1999 A aterosclerose pode ser considerada uma doença na circulação coronariana. O presente trabalho estuda a ação da quercetina, morina, ácido nicotínico de maneira isolada e em associação envolvendo quercetina + ácido nicotínico e morina + ácido nicotínico ...
Oliveira, Tânia Toledo de +5 more
core +3 more sources
EFFECT OF NICOTINIC ACID SUPPLEMENTATION ON PRODUCTION PERFORMANCE OF LACTATING COWS [PDF]
Journal of Veterinary and Animal Sciences, 2009 The effect of dietary supplementation of nicotinic acid on milk yield and milk fat percentage was studied in twelve lactating cows allotted at random to treatments T1 and T2.
Renjith Gopal +4 more
doaj
In Vivo Incorporation of Multiple Unnatural Amino Acids [PDF]
, 2009 Unnatural amino acid (UAA) incorporation is an invaluable technique that is seeing increased use. THG73 is an amber suppressor tRNA used to incorporate > 100 residues at the UAG, amber stop codon, in Xenopus oocytes.
Rodriguez, Erik Ali
core +1 more source
Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development
Advanced Healthcare Materials, EarlyView.LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans +7 more
wiley +1 more source
Molecules, 2008 This study found that in Tris-HCl buffer, the resonance light scattering (RLS) intensity of the Eu3+-nicotinic acid system can be greatly enhanced by nucleic acids and the enhanced intensity is proportional to the concentration of nucleic acid in the ...
Jing-He Yang +4 more
doaj +1 more source