Results 151 to 160 of about 5,143,045 (401)

Effects of Lactobacillus fermentum GKF3 on Reducing Smoking and Brain Neurotransmitter Levels: Findings From Animal and Human Studies

open access: yesFood Frontiers, EarlyView.
1.Developing food‐grade probiotic strains with smoking reduction benefits presents a safer and more holistic health strategy. 2.An animal study demonstrated that L. fermentum GKF3 gavage elevated brain dopamine and serotonin levels. 3.A randomized controlled trial showed that L.
You‐Shan Tsai   +6 more
wiley   +1 more source

Bioactive Polysaccharides Targeting Gut Microbiota to Modulate Host Health: A Gear Effect Theory

open access: yesFood Frontiers, EarlyView.
The “Gear Effect” mechanism of bioactive polysaccharides driving gut microbiota to modulate host health. ABSTRACT Bioactive polysaccharides are macromolecular polymers with broad biological activities. Recent evidence has highlighted their role in modulating host health primarily through interactions with gut microbiota.
Yonggan Sun   +3 more
wiley   +1 more source

Opening a hydrophobic gate: the nicotinic acetylcholine receptor as an example [PDF]

open access: yesarXiv, 2009
To what extent must a hydrophobic gate expand for the channel to count as open? We address this question using the nicotinic acetylcholine receptor (nAChR) as the exemplar. The nAChR is an integral membrane protein which forms a cation selective channel gated by neurotransmitter binding to its extracellular domain.
arxiv  

Research progress on the mechanisms of pain empathy

open access: yesIbrain, EarlyView.
This article is related to the graphical research progress of pain empathy, starting with the description of the pain matrix and mirror neurons. Based on the pain matrix and mirror neurons, pain empathy results from the combined action of brain regions such as the anterior cingulate cortex, insula, prefrontal cortex, and amygdala and regulatory ...
Shuangshuang Liu   +5 more
wiley   +1 more source

Predicting Smoking Events with a Time-Varying Semi-Parametric Hawkes Process Model [PDF]

open access: yesarXiv, 2018
Health risks from cigarette smoking -- the leading cause of preventable death in the United States -- can be substantially reduced by quitting. Although most smokers are motivated to quit, the majority of quit attempts fail. A number of studies have explored the role of self-reported symptoms, physiologic measurements, and environmental context on ...
arxiv  

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

open access: yesIbrain, EarlyView.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra   +4 more
wiley   +1 more source

Turnover Modeling of Non-Esterified Fatty Acids in Rats after Multiple Intravenous Infusions of Nicotinic Acid

open access: yesDose-Response, 2009
The objective of this investigation was to use a pharmacokinetic (PK)/pharmacodynamic (PD) approach to describe and evaluate a PK model of nicotinic acid (NiAc) in guinea pigs and a PD feedback model of changes in non-esterified fatty acid (NEFA ...
Christine Isaksson   +4 more
doaj   +1 more source

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang   +7 more
wiley   +1 more source

Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

open access: yesMolecular Metabolism, 2020
Objectives: Long-chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which is highly expressed in adipocytes, may be involved in this feedback ...
Anna Sofie Husted   +13 more
doaj  

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