Results 171 to 180 of about 28,497 (246)

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson   +7 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone   +1 more
wiley   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li   +19 more
wiley   +1 more source

Toward Metabolomics Analyses With Combined Capillary Vibrating Sharp‐Edge Spray Ionization and Atmospheric Pressure Chemical Ionization

open access: yesRapid Communications in Mass Spectrometry, Volume 40, Issue 17, 15 September 2026.
ABSTRACT Rationale The varied properties of metabolomics components dictate the tools used in mass spectrometry (MS) characterization including the selection of the ionization source. However, the ionization of select compounds limits characterization efficiency.
Madison Pursell   +14 more
wiley   +1 more source

Plasma nicotinamide adenine dinucleotide pathway depletion is linked to diastolic dysfunction in patients with advanced chronic liver disease. [PDF]

open access: yesCardiovasc Res
Gill M   +10 more
europepmc   +1 more source

Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment‐Naive Patients Compared With Zoledronate

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 139-149, July 2026.
We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu   +2 more
wiley   +1 more source

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