Results 81 to 90 of about 5,143,045 (401)

Simple modifications of nicotinic, isonicotinic, and 2,6-dichloroisonicotinic acids toward new weapons against plant diseases

Open Chemistry, 2021
Recently, the biggest challenge in agriculture is the search for new, effective, and ecological methods of protecting plants against diseases. One of the fastest-growing and prospective strategies is a method based on activating the plant’s natural ...
Czerwoniec Patrycja, Szymkowiak Joanna, Smiglak Marcin   +2 more
doaj   +1 more source

The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking. [PDF]

, 2020
Nicotinic acetylcholine receptors (AChRs) are pentameric channels that mediate fast transmission at the neuromuscular junction (NMJ) and defects in receptor expression underlie neuromuscular disorders such as myasthenia gravis and congenital myasthenic ...
Borges, Lucia Soares, Ferns, Michael, Rudell, Jolene Chang, Yarov-Yarovoy, Vladimir   +3 more
core  

Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]

, 2017
Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos, Bouzat, Cecilia Beatriz, Collins, Toby, Corradi, Jeremias, Craig, Patricio Oliver, Elgoyhen, Ana Belen, Gill Thind, JasKiran K., Lipovsek, Maria Marcela, Marcovich, Irina, Millar, Neil S., Moglie, Marcelo Javier, Plazas, Paola Viviana   +11 more
core   +3 more sources

The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects.

Journal of Clinical Investigation, 1999
We have quantitatively determined gluconeogenesis (GNG) from all precursors, using a novel method employing 2H20 to address the question of whether changes in plasma free fatty acids (FFA) affect GNG in healthy, nonobese subjects. In the first study (n =
Xinhua Chen, Nayyar Iqbal, G. Boden
semanticscholar   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Similarity Between the Action of Pteridines and Tryptophan Metabolites on Lipid Metabolism

Pteridines, 1999
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol. The addition of anthranilic acid (2.2 and
Rudzite Vera, Jurika Edite, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +1 more source

Untying Surface Chemistry and Emulsion Stability to Construct Multifunctional Pickering Emulsion SERS Sensors for Pretreatment‐Free Quantitative Analysis in Bio‐Media

Advanced Science, EarlyView.
A dual‐particle interfacial self‐assembly approach is used to create surface‐accessible Pickering emulsions with Au@Prussian blue nanoparticles acting as the functional component. These emulsions have strong plasmonic properties and are equipped with molecular sieves and internal standards.
Yingrui Zhang, Chunchun Li, Ruairi Carland, Ziwei Ye, Steven E. J. Bell, Yikai Xu   +5 more
wiley   +1 more source

Plant Organic Acids as Natural Inhibitors of Foodborne Pathogens

Applied Sciences
Background: Foodborne infections affect approximately 600 million people annually. Simultaneously, many plants contain substances like organic acids, which have antimicrobial activity. The aim of this study was to examine the effects of 21 organic acids,
Tomasz M. Karpiński, Marcin Ożarowski
doaj   +1 more source

DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION

Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, 2015
Coordination compounds of essential microelement germanium(IV) with metals (Mg, Na, K, Ca, Cu, etc.) and organic ligands – biocatalysts, antidotes at intoxications and regulators of mineral metabolism in living organism (nicotinic, citric, tartaric, 1 ...
I. I. Seifullina, E. E. Martsinko, E. V. Afanasenko   +2 more
doaj   +1 more source

A weighted U statistic for association analysis considering genetic heterogeneity [PDF]

, 2015
Converging evidence suggests that common complex diseases with the same or similar clinical manifestations could have different underlying genetic etiologies. While current research interests have shifted toward uncovering rare variants and structural variations predisposing to human diseases, the impact of heterogeneity in genetic studies of complex ...
arxiv   +1 more source