Results 71 to 80 of about 925,140 (188)
Química Nova, 2011 This work describes the creation of an very simple calculation algorithm, based in basic chemical and mathematic principles, for the calculation of weak diprotic acid dissociation constants as, for example, amino acids, from potentiometric titrations ...
Elsa M. Gonçalves +1 more
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, 2005 Binding of agonists to nicotinic acetylcholine receptors generates a sequence of conformational changes resulting in channel opening. Previously, we have shown that the aspartate residue Asp-266 at the M2-M3 linker of the α7 nicotinic receptor is ...
Criado Herrero, Manuel +4 more
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Nicotine addiction : a review [PDF]
, 2013 Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
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Molecular orbital studies on nicotinic acid, nicotinamide and related compounds
, 1978 Electronic structures of nicotinic, isonicotinic and 2-picolinic acids and their amides have been investigated, using the variable-? Pariser-Parr-Pople (PPP), iterative extended Hückel and MINDO/2 methods.
C.C. Patel +5 more
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Атеросклероз, 2016 This article is devoted to discussion about main aspects of current use of non-statin hypolipidemic drugs according last international guidelines (including fibrates, nicotinic acid, resins, polyunsaturated fatty acids, ezetimibe, PCSK9-inhibitors).
A. E. Bagriy +6 more
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Regioselective Cross-Coupling Reactions of Boronic Acids with Dihalo Heterocycles
, 2016 The carboxylic acid anion moiety has been used as a tunable directing group in the cross-coupling reaction of 2,6-dichloronicotinic acid and 2,5-dibromo-1,2,4-triazole derivatives producing selectively the 2- or 6-substituted nicotinic acids, while only ...
Yukuan Yuan (2259064) +5 more
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Nicotinic receptors as targets for novel analgesics and anti-infl ammatory drugs
, 2014 Nicotine and nicotinic receptors have been explored for the past three decades as a strategy for pain control. These receptors are widely expressed throughout the central and peripheral nervous system as well as immune cells.
Freitas, Kelen C.C. +3 more
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EFSA Journal, 2012 The term ‘niacin’ is used as generic description of nicotinic acid and nicotinamide with pyridine as the basic structure. Nicotinic acid and nicotinamide function mainly as precursors of the co‐enzymes NAD and NADP. Thus, nicotinamide has physiologically
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
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Nicotinic acetylcholine receptors of nerve and muscle: Functional aspects
, 1987 Cloning studies suggest that there are at least five types of nicotinic receptor with different amino acid sequences. David Colquhoun and colleagues discuss pharmacological consequences of this heterogeneity.
David Colquhoun +2 more
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Nicotinic Acetylcholine Receptors are Possible Therapeutic Targets for Schizophrenia [PDF]
, 2010 The rate of smoking in patients with schizophrenia is higher than that in the general population. Nicotinic acetylcholine receptors (nAChR) are involved in the sensorimotor gating deficits in schizophrenia.
川崎, 博己 +11 more
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