Results 71 to 80 of about 872,363 (287)

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Elucidating the Structure-Activity Relationships of the Vasorelaxation and Antioxidation Properties of Thionicotinic Acid Derivatives

Molecules, 2010
Nicotinic acid, known as vitamin B3, is an effective lipid lowering drug and intense cutaneous vasodilator. This study reports the effect of 2-(1-adamantylthio)nicotinic acid (6) and its amide 7 and nitrile analog 8 on phenylephrine-induced contraction ...
Virapong Prachayasittikul, Somsak Ruchirawat, Chanin Nantasenamat, Apilak Worachartcheewan, Orapin Wongsawatkul, Supaluk Prachayasittikul   +5 more
doaj   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure [PDF]

, 2012
Background: Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking ...
Timpson, NJ, Upton, Mark N, Johnstone, Elaine, Vineis, Paolo, Morris, Richard W, Johnson, Paul C. D., Johnson, P.C.D., Uhl, GR, Amuzu, A., Aveyard, P., Munafò, Marcus R., Sattar, N, Watt, G., Walther, Donna, Ebrahim, S, Timofeeva, M.N., Hingorani, AD, Upton, M.N., Morris, Richard W., Johnson, PC, Riboli, E., Munafò, Marcus R, Watt, Graham, Ebrahim, Shah, Relton, C., Jefferis, BJ, Timofeeva, Maria N., Casas, Juan P., Riboli, E, Riboli, Elio, Padmanabhan, S., Palmer, T.M., Prieto-Merino, D, Jefferis, Barbara J., Vineis, P., Munafo, M.R., Amuzu, Antoinette, Prieto-Merino, D., ?, ?, Brennan, P., Hingorani, Aroon D, Padmanabhan, Sandosh, Uhl, G.R., Morris, RW, Uhl, George R, Prieto-Merino, David, Johnson, Paul CD, Timpson, Nicholas J., Whincup, PH, Whincup, P.H., Palmer, Tom M, Johnstone, E.C., Sattar, N., Johnstone, Elaine C., Johnson, Paul C D, Hingorani, A.D., Jefferis, B.J., Brennan, P, Upton, Mark N., Davey Smith, George, Upton, MN, EPIC Study Group, Ebrahim, S., Davey Smith, G, Jefferis, Barbara J, Whincup, Peter H, Uhl, George R., Timofeeva, MN, Timofeeva, Maria N, Aveyard, P, Timpson, Nicholas J, Relton, Caroline, Sattar, Naveed, Casas, Juan P, Amuzu, A, Brennan, Paul, Munafò, MR, Palmer, TM, Relton, C, Walther, D., Vineis, P, Timpson, N.J., Watt, G, Hingorani, Aroon D., Casas, JP, Johnstone, Elaine C, Padmanabhan, S, Casas, J.P., Davey Smith, G., Palmer, Tom M., Johnstone, EC, Walther, D, Whincup, Peter H., Morris, R.W., Aveyard, Paul   +94 more
core   +3 more sources

Probiotic innovations: bacillus species in dermatology and cosmetology [PDF]

Surgical & Cosmetic Dermatology
In recent years, the use of probiotics in dermatology and cosmetology has been demonstrating a notable rise, offering both preventive and therapeutic benefits for the skin. The intestinal microbiota plays crucial roles, including enzymatic degradation of
Yana Yemchenko, Kateryna Bardova, Oleh Akimov, Anatolii Levkov, Heorhii Kostenko, Viktoriia Kostenko, Artur Mishchenko, Natalia Solovyova, Vitalii Kostenko   +8 more
doaj   +1 more source

Effect of extruded grain feed, with the preliminary germination of rapeseed, on the cicatricial digestion of dairy cows and calves

BIO Web of Conferences, 2020
This article describes the scientific and production experience conducted in the Druzhba LLC, of the Buinsky district of the Republic of Tatarstan. The purpose of the scientific and production experiment is to study the effect of extruded feed, with the ...
Sofronov Vladimir, Fayzrakhmanov Ramil, Yamaev Elvir, Danilova Nadezhda, Kuznetsova Elena, Sofronov Pavel   +5 more
doaj   +1 more source

Improving the Physicochemical Properties, Organic Acids, Amino Acids, Volatile Organic Compounds, and Metabolites of Laohan Melon Juice Through Fermentation With Different Lactic Acid Bacteria

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Fermentation with lactic acid bacteria could improve amino acids, volatile organic compounds (VOCs), and nonvolatile metabolites of Laohan melon juice (LMJ), which provides theoretical guidance for the development of Laohan melon beverage and advances knowledge of the metabolic mechanisms of VOCs in LMJ.
Yun Xie, Sihan Hou, Mingdong Tan, Jianqiao Jiang, Yue Hu, Yiwen Chen, Yongkang Li, Miao Cui, Jianming Niu, Weidong Cheng, Xilei Pu, Yuyun He, Feifei Gao   +12 more
wiley   +1 more source

Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]

, 1999
In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Puhl, G., Neuhaus, P., Schön, M. R., Hammer, C., Matthes, M., Heil, W., Lemmens, H.-P., Padval, D.   +7 more
core   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Pyridinium salts of dithiophosphoric acids on the basis of nicotinic acids and their isomers, 3-hydroxypyridine, and 3-pyridinemethanol

, 2019
© 2019, © 2019 Taylor & Francis Group, LLC. A new series of chiral carboxypyridinium dithiophosphates were synthesized by the reactions of nicotinic, isonicotinic, and picolinic acids with dithiophosphoric acid on the basis (1S)-endo-(–)-borneol in ...
Batyeva E., Timushev I., Nizamov I., Salikhov R., Shulaeva M., Cherkasov R., Ponomareva A., Pozdeev O., Nikitin Y., Yakimov V.   +9 more
core   +2 more sources