Results 101 to 110 of about 481,268 (346)

GTS-21, a nicotinic agonist, attenuates multiple infarctions and cognitive deficit caused by permanent occlusion of bilateral common carotid arteries in rats.

Japanese Journal of Pharmacology, 1998
We examined the effects of GTS-21 [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], a nicotinic agonist, on histopathological changes of the brain and radial maze learning performance in rats with permanent occlusion of the bilateral common ...
M. Nanri, H. Miyake, Y. Murakami, Kinzo Matsumoto, H. Watanabe   +4 more
semanticscholar   +1 more source

Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure

iMeta, EarlyView.
Prenatal prednisone therapy (PPT)/prenatal prednisone exposure (PPE) induces long bone dysplasia, reduced peak bone mass (PBM), and increased osteoporosis susceptibility in female offspring. Maternal gut microbiota metabolite daidzein (DAI) mediates PPE‐induced osteoporosis susceptibility in female adult offspring.
Chi Ma, Hangyuan He, Kunpeng Wang, Juanjuan Guo, Liang Liu, Yuting Chen, Bin Li, Hao Xiao, Xufeng Li, Xiaoqian Lu, Tingting Wang, Yinxian Wen, Hui Wang, Liaobin Chen   +13 more
wiley   +1 more source

Achieving maximal speed of solution exchange for patch clamp experiments. [PDF]

PLoS ONE, 2012
BACKGROUND: Resolving the kinetics of agonist binding events separately from the subsequent channel gating processes requires the ability of applying and removing the agonist before channel gating occurs.
Jerónimo Auzmendi, Darío Fernández Do Porto, Carla Pallavicini, Luciano Moffatt   +3 more
doaj   +1 more source

Structural Analysis and Deletion Mutagenesis Define Regions of QUIVER/SLEEPLESS that Are Responsible for Interactions with Shaker-Type Potassium Channels and Nicotinic Acetylcholine Receptors. [PDF]

, 2016
Ly6 proteins are endogenous prototoxins found in most animals. They show striking structural and functional parallels to snake α-neurotoxins, including regulation of ion channels and cholinergic signaling.
Joiner, William J, Liu, Clifford Z, Wu, Meilin   +2 more
core   +4 more sources

Neurotensin Agonist Attenuates Nicotine Potentiation to Cocaine Sensitization [PDF]

Behavioral Sciences, 2014
Tobacco usage typically precedes illicit drug use in adolescent and young adult populations. Several animal studies suggest nicotine increases the risk for subsequent cocaine abuse, and may be a negative prognostic factor for treatment of cocaine addiction; i.e., a “gateway drug”. Neurotensin (NT) is a 13-amino acid neuropeptide that modulates dopamine,
Bethany Stennett, Paul A. Fredrickson, Mona Boules, Elliott Richelson   +3 more
openaire   +4 more sources

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior [PDF]

, 2003
Prenatal nicotine exposure has been linked to attention deficit hyperactivity disorder and cognitive impairment, but the sites of action for these effects of nicotine are still under investigation. High-affinity nicotinic acetylcholine receptors (nAChRs)
Caldarone, Barbara J, Collins, Allan C, Grady, Sharon R, King, Sarah L, Koren, Andrei O, Marks, Michael J, Mukhin, Alexey G, Picciotto, Marina R   +7 more
core   +2 more sources

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimer’s disease [PDF]

arXiv, 2019
The tight coupling between neuronal activity and the local increase of blood flow termed neurovascular coupling is essential for normal brain function. This mechanism of regulation is compromised in Alzheimer's Disease (AD). In order to determine whether a purely vascular dysfunction or a neuronal alteration of blood vessels diameter control could be ...
arxiv  

Openings of the rat recombinant alpha1 homomeric glycine receptor as a function of the number of sgonist molecules bound [PDF]

, 2002
The functional properties of rat homomeric {alpha}1 glycine receptors were investigated using whole-cell and outside-out recording from human embryonic kidney cells transfected with rat {alpha}1 subunit cDNA.
Beato, M., Colquhoun, D., Groot-Kormelink, P.J., Sivilotti, L.G.   +3 more
core