The role of alpha-7 nicotinic receptors in food intake behaviors
Frontiers in Psychology, 2014 Nicotine alters appetite and energy expenditure, leading to changes in body weight. While the exact mechanisms underlying these effects are not fully established, both central and peripheral involvement of the alpha-7 nicotinic acetylcholine receptor ...
Kristina L. McFadden +3 more
doaj +1 more source
The SARS-CoV-2 Virus and the Cholinergic System: Spike Protein Interaction with Human Nicotinic Acetylcholine Receptors and the Nicotinic Agonist Varenicline. [PDF]
Int J Mol Sci, 2023 Carlson EC +4 more
europepmc +1 more source
Monthly buprenorphine depot injection (SUBLOCADE®) for opioid use disorder during pregnancy
The American Journal on Addictions, EarlyView.Abstract Background and Objectives Untreated opioid use disorder (OUD) in pregnancy is associated with adverse obstetrical outcomes, maternal morbidity, and maternal mortality. This article will inform clinicians about the use of monthly extended‐release buprenorphine (BUP‐XR, SUBLOCADE®) to treat OUD during pregnancy and postpartum.
Melinda Ramage +3 more
wiley +1 more source
Neural Regeneration Research, 2017 Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked.
Laura Foucault-Fruchard, Daniel Antier
doaj +1 more source
Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex.
Japanese Journal of Pharmacology, 1997 Anabaseine is a naturally occurring toxin that stimulates a variety of neuronal and muscle nicotinic receptors. GTS-21 [3-(2,4-dimethoxybenzylidene)anabaseine], an anabaseine derivative, selectively stimulates alpha 7-containing nicotinic receptors. Here
K. Summers, W. Kem, E. Giacobini
semanticscholar +1 more source
Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor
Biophysical Journal, 1991 The nicotinic acetylcholine receptor (AChR) is a pentameric transmembrane protein (alpha 2 beta gamma delta) that binds the neurotransmitter acetylcholine (ACh) and transduces this binding into the opening of a cation selective channel. The agonist, competitive antagonist, and snake toxin binding functions of the AChR are associated with the alpha ...
Gordon F. Tomaselli +4 more
openaire +3 more sources
Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor [PDF]
, 2011 Cys-loop receptor binding sites characteristically possess an "aromatic box," where several aromatic amino acid residues surround the bound ligand. A cation-π interaction between one of these residues and the natural agonist is common, although the ...
Ashby, Jamie A. +3 more
core
Compression‐Expansion: Miniaturization, Modularity, and Logistics Beyond Earth
American Anthropologist, EarlyView.ABSTRACT If the Cold War space race culminated in a return to Earth, at present we are experiencing a renewed interest in space. Drawing on fieldwork among people working in the space sector in Sweden, this article focuses on some of the imaginaries underpinning this resurgence and the contemporary commercialization of space. Specifically, I hone in on
Chakad Ojani
wiley +1 more source
Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development. [PDF]
, 2013 RationaleImpaired cognitive abilities are a key characteristic of schizophrenia. Although currently approved pharmacological treatments have demonstrated efficacy for positive symptoms, to date no pharmacological treatments successfully reverse cognitive
Acheson, Dean T +2 more
core +2 more sources
Preferences between three options for androgen deprivation therapy: a focus group study
BJU International, EarlyView.Objectives Androgen deprivation therapy (ADT) forms the mainstay of treatment for advanced prostate cancer. Traditionally administered as a luteinising hormone‐releasing hormone (LHRH) agonist depot injection, newer options for ADT include transdermal oestradiol patches (tE2) or oral LHRH antagonists.
Hannah L. Rush +13 more
wiley +1 more source