Results 11 to 20 of about 2,143 (224)
Using the Honey Bee (Apis mellifera L.) Cell Line AmE‐711 to Evaluate Insecticide Toxicity
Environmental Toxicology and Chemistry, Volume 42, Issue 1, Page 88-99, January 2023., 2023 Abstract One of the main contributors to poor productivity and elevated mortality of honey bee colonies globally is insecticide exposure. Whole‐organism and colony‐level studies have demonstrated the effects of insecticides on many aspects of honey bee biology and have also shown their interactions with pathogens.
Michael Goblirsch, John J. Adamczyk
wiley +1 more source
Environmental Toxicology and Chemistry, Volume 42, Issue 1, Page 71-87, January 2023., 2023 Abstract For the majority of developed adverse outcome pathways (AOPs), the taxonomic domain of applicability (tDOA) is typically narrowly defined with a single or a handful of species. Defining the tDOA of an AOP is critical for use in regulatory decision‐making, particularly when considering protection of untested species.
Marissa A. Jensen +2 more
wiley +1 more source
Nicotine receptor partial agonists for smoking cessation [PDF]
Cochrane Database of Systematic Reviews, 2016 Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist).To review the efficacy of nicotine receptor partial agonists, including varenicline and cytisine, for smoking ...
Cahill, Kate +4 more
openaire +5 more sources
A review of frequently used Kampo prescriptions part 1. Daikenchuto
Traditional &Kampo Medicine, Volume 9, Issue 3, Page 151-179, December 2022., 2022 Abstract Background The original formula name for daikenchuto (DKT) was written in ‘Jin Gui Yao Lue (Kinkiyōryaku in Japanese)’. DKT as used in Japan consists of four types of crude drug. Key findings Although there are few examples of its use in Chinese classical records, it has begun to be used extensively in modern Japan for intestinal obstruction ...
Takao Namiki +5 more
wiley +1 more source
Dynamic imaging and characterization of volatile aerosols in e-cigarette emissions using deep learning-based holographic microscopy [PDF]
ACS Sensors (2021), 2021 Various volatile aerosols have been associated with adverse health effects; however, characterization of these aerosols is challenging due to their dynamic nature. Here we present a method that directly measures the volatility of particulate matter (PM) using computational microscopy and deep learning.
arxiv +1 more source
Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin [PDF]
Front. Immunol. 2019, 2018 Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes
arxiv +1 more source
British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 279-289, January 2023., 2023 Aims Active vitamin D deficiency is associated with increased aortic‐pulse wave velocity (Ao‐PWV) in people with type 2 diabetes (T2DM) and chronic kidney disease (CKD). There are no randomised controlled trials investigating the effect of active vitamin D treatment on Ao‐PWV in people with T2DM and CKD.
Janaka Karalliedde +10 more
wiley +1 more source
Pharmacological Research, 2023 The promise of nicotinic receptors as a therapeutic target has yet to be fully realized, despite solid data supporting their involvement in neurological and neuropsychiatric diseases.
Talulla B. Palumbo, Julie.M. Miwa
doaj
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
Nature Communications, 2016 Airway hyperreactivity is driven by type 2 cytokines produced by ILC2 and Th2 cells. Here the authors show that an α7-nicotinic receptor agonist (GTS-21) inhibits ILC2 responses and is therapeutic against Alternaria-induced airway hyperreactivity in a ...
Lauriane Galle-Treger +7 more
doaj +1 more source