Results 21 to 30 of about 493,465 (339)
Differential Contribution of Subunit Interfaces to α 9 α 10 Nicotinic Acetylcholine Receptor Function [PDF]
, 2017 Nicotinic acetylcholine receptors can be assembled from either homomeric or heteromeric pentameric subunit combinations. At the interface of the extracellular domains of adjacent subunits lies the acetylcholine binding site, composed of a principal ...
Boffi, Juan Carlos +11 more
core +3 more sources
Scientific Reports, 2016 We demonstrated previously that phosphocholine and phosphocholine-modified macromolecules efficiently inhibit ATP-dependent release of interleukin-1β from human and murine monocytes by a mechanism involving nicotinic acetylcholine receptors (nAChR ...
K. Richter +10 more
semanticscholar +1 more source
Nicotine receptor partial agonists for smoking cessation
Cochrane Database of Systematic Reviews, 2023 Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). This is an update of a Cochrane Review first published in 2007.To assess the effectiveness of nicotine ...
Livingstone-Banks, J +6 more
openaire +4 more sources
Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel [PDF]
, 1982 These experiments examine changes in the agonist-induced conductance that occur when the agonist-receptor complex is perturbed. Voltage-clamped Electrophorus electroplaques are exposed to the photoisomerizable agonist trans-Bis-Q A 1-µs laser flash ...
Lester, Henry A., Sheridan, Robert E.
core +1 more source
An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors*
Journal of Biological Chemistry, 2015 Background: In (α4β2)2α4 nicotinic acetylcholine receptors, there is an agonist binding site at the α4/α4 subunit interface. Results: α2, α3, and α6 accessory subunits can form an agonist site with α4.
Jingyi Wang +6 more
semanticscholar +1 more source
Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists [PDF]
British Journal of Pharmacology, 1999 The dose‐response parameters of recombinant mouse adult neuromuscular acetylcholine receptor channels (nAChR) activated by carbamylcholine, nicotine, muscarine and oxotremorine were measured. Rate constants for agonist association and dissociation, and channel opening and closing, were estimated from single‐channel kinetic analysis.
G, Akk, A, Auerbach
openaire +2 more sources
Nicotine receptor partial agonists for smoking cessation [PDF]
Sao Paulo Medical Journal, 2007 Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). Varenicline was developed as a nicotine receptor partial agonist from cytisine, a drug widely used in central
Cahill, Kate +3 more
openaire +17 more sources
The effect of amixin and agmatine on cytochrome c release from isolated mitochondria [PDF]
The Ukrainian Biochemical Journal, 2017 Mitochondrial nicotinic acetylcholine receptors (nAChRs) control permeability transition pore formation and cytochrome c release in the presence of apoptogenic factors.
K. R. Uspenska +3 more
doaj +1 more source
A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart [PDF]
, 1982 These experiments employ the photoisomerizable compound, 3,3'-bis- [alpha-(trimethylammonium)methyl]azobenzene (Bis-Q), to study the response to muscarinic agents in frog myocardium. In homogenates from the heart, trans-Bis-Q blocks the binding of [3H]-N-
Birdsall, Nigel J. M. +5 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance In this study we take advantage of a recently described chimera of the α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding protein (AChBP), termed α7-AChBP.
R. Spurny +11 more
semanticscholar +1 more source