Results 31 to 40 of about 2,143 (224)
Frontiers in Immunology, 2018 Blood levels of the acute phase reactant C-reactive protein (CRP) are frequently measured as a clinical marker for inflammation, but the biological functions of CRP are still controversial.
Katrin Richter +22 more
doaj +1 more source
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning [PDF]
The EMBO Journal 27, 9 (2008) 1321-1332, 2008 The G-protein-coupled receptor (GPCR) activated by the neurotransmitter GABA is made up of two subunits, GABA(B1) and GABA(B2). GABA(B1) binds agonists, whereas GABA(B2) is required for trafficking GABA(B1) to the cell surface, increasing agonist affinity to GABA(B1), and activating associated G proteins.
arxiv +1 more source
Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists [PDF]
British Journal of Pharmacology, 1999 The dose‐response parameters of recombinant mouse adult neuromuscular acetylcholine receptor channels (nAChR) activated by carbamylcholine, nicotine, muscarine and oxotremorine were measured. Rate constants for agonist association and dissociation, and channel opening and closing, were estimated from single‐channel kinetic analysis.
Gustav Akk, Anthony Auerbach
openaire +3 more sources
Frontiers in Neuroanatomy, 2017 Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and ...
Mohammed Z. Ariffin +4 more
doaj +1 more source
Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit [PDF]
The Journal of Biological Chemistry 279, 16 (2004) 15824-30, 2008 The gamma-aminobutyric acid type B (GABAB) receptor is an allosteric complex made of two subunits, GABAB1 (GB1) and GABAB2 (GB2). Both subunits are composed of an extracellular Venus flytrap domain (VFT) and a heptahelical domain (HD). GB1 binds GABA, and GB2 plays a major role in G-protein activation as well as in the high agonist affinity state of ...
arxiv +1 more source
1,2,3,4-Tetrahydro-1,4-methanonaphthalene-2,3-diol
Acta Crystallographica Section E, 2009 The title compound, C11H12O2, is an intermediate in the synthesis of Varenicline, a nicotinic receptor partial agonist used to treat smoking addiction. In the crystal structure, there is an intramolecular O—H...O hydrogen bond that generates an S(5)
Jian Xu +4 more
doaj +1 more source
Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor [PDF]
PLoS Comp. Biol. (2015) 11(2): e1004044, 2014 Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the structural and dynamical origin of ligand-dependent modulation of GPCR activity, we performed total $\sim$ 5 $\mu$sec molecular dynamics simulations of A$_{2A}$ adenosine ...
arxiv +1 more source
Frontiers in Pharmacology, 2017 The existence of a cholinergic anti-inflammatory pathway negatively modulating the inflammatory and immune responses in various clinical conditions and experimental models has long been postulated.
Andrea Grandi +7 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2002 Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses.
C.M. Kerchove +3 more
doaj +1 more source
Sulfonium Ligands of the α7 nAChR
Molecules, 2021 The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor are ...
Nicole A. Horenstein +2 more
doaj +1 more source