An Accessory Agonist Binding Site Promotes Activation of α4β2* Nicotinic Acetylcholine Receptors*
Journal of Biological Chemistry, 2015 Background: In (α4β2)2α4 nicotinic acetylcholine receptors, there is an agonist binding site at the α4/α4 subunit interface. Results: α2, α3, and α6 accessory subunits can form an agonist site with α4.
Jingyi Wang +6 more
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Pharmacological Research, 2023 The promise of nicotinic receptors as a therapeutic target has yet to be fully realized, despite solid data supporting their involvement in neurological and neuropsychiatric diseases.
Talulla B. Palumbo, Julie.M. Miwa
doaj
Marine Drugs, 2015 6-Bromohypaphorine (6-BHP) has been isolated from the marine sponges Pachymatisma johnstoni, Aplysina sp., and the tunicate Aplidium conicum, but data on its biological activity were not available.
Igor E. Kasheverov +7 more
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Functional Stoichiometry at the Nicotinic Receptor. The Photon Cross Section for Phase 1 Corresponds to Two Bis-Q Molecules per Channel [PDF]
, 1982 These experiments examine changes in the agonist-induced conductance that occur when the agonist-receptor complex is perturbed. Voltage-clamped Electrophorus electroplaques are exposed to the photoisomerizable agonist trans-Bis-Q A 1-µs laser flash ...
Lester, Henry A., Sheridan, Robert E.
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Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance In this study we take advantage of a recently described chimera of the α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding protein (AChBP), termed α7-AChBP.
R. Spurny +11 more
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Soil nematode Caenorhabditis elegans Maupas as a convenient model organism to study anthelmintic activity of plant extracts [PDF]
E3S Web of Conferences, 2020 The article deals with the study of the possibility to use free-living soil nematode C. elegans in researches of anthelmintic activity of plant raw material. A. sativum juice and aqueous extract of T. vulgare flowers were used in experiments. It is shown
Egorova Anastasia +4 more
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Molecular adsorption study of nicotine and caffeine on the single-walled carbon nanotube from first principles [PDF]
Solid State Communications, v.167, pp.27 - 30 (2013), 2012 Using first-principles calculations, we investigate the electronic structures and binding properties of nicotine and caffeine adsorbed on single-walled carbon nanotubes to determine whether CNTs are appropriate for filtering or sensing nicotine and caffeine molecules. We find that caffeine adsorbs more strongly than nicotine.
arxiv +1 more source
Identification of critical residues in loop E in the 5-HT(3AS)R binding site [PDF]
, 2002 BACKGROUND: The serotonin type 3 receptor (5-HT(3)R) is a member of a superfamily of ligand gated ion channels. All members of this family share a large degree of sequence homology and presumably significant structural similarity.
Joshi, Prasad R +4 more
core +3 more sources
The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits. [PDF]
PLoS Pathogens, 2009 Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasite ...
Sally M Williamson +7 more
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Single Molecule Transistor based Nanopore for the detection of Nicotine [PDF]
Journal of Applied Physics 116, 244307 (2014), 2015 A nanopore based detection methodology was proposed and investigated for the detection of Nicotine. This technique uses a Single Molecular Transistor (SMT) working as a nanopore operational in the Coulomb Blockade regime. When the Nicotine molecule is pulled through the nanopore area surrounded by the Source(S), Drain(D) and Gate electrodes, the charge
arxiv +1 more source