Results 51 to 60 of about 39,324 (314)
Brazilian Journal of Medical and Biological Research, 2002 Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses.
C.M. Kerchove +3 more
doaj +1 more source
Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. [PDF]
PLoS ONE, 2014 Three recently discovered tentacle muscles are crucial to perform patterned movements of upper tentacles of the terrestrial snail, Helix pomatia. The muscles receive central and peripheral excitatory cholinergic innervation lacking inhibitory innervation.
Tibor Kiss +3 more
doaj +1 more source
Sulfonium Ligands of the α7 nAChR
Molecules, 2021 The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor are ...
Nicole A. Horenstein +2 more
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Suppression of methamphetamine-seeking behavior by nicotinic agonists [PDF]
Proceedings of the National Academy of Sciences, 2006 To understand the mechanism of methamphetamine (MAP) craving from the viewpoint of nicotinic acetylcholinergic transmission, we examined the responsible site of the brain for anticraving effects produced by nicotinic agonists by using a MAP self-administration paradigm in rats.
Katsuya Sakimura +4 more
openaire +3 more sources
Wareniklina – częściowy agonista receptorów nikotynowych w terapii zespołu uzależnienia od alkoholu
Alcoholism and Drug Addiction, 2016 The pharmacotherapy currently used for alcohol dependence may reduce alcohol consumption and extend abstinence periods. However, it is effective in only about 30% of addicted subjects.
Natalia Obsada +1 more
doaj +1 more source
Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]
, 2008 We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel +81 more
core +1 more source
Medicina, 2015 Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas +2 more
doaj +1 more source
Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors [PDF]
, 2007 Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D. +3 more
core +2 more sources
Neuroreceptor Activation by Vibration-Assisted Tunneling [PDF]
Scientific Reports 5, Article number: 9990 Published 2015, 2015 G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous ...
arxiv +1 more source
International Clinical Neuroscience Journal, 2018 Background: Sleep disorder or sleep deprivation (SD) is a common issue in today’s society. Numerous evidences show that sleep is essential for proper brain performance and cognitive processes; on the other hand, cognitive functions have a broad range ...
Bibi-Zahra Javad-Moosavi +4 more
doaj +1 more source