Results 51 to 60 of about 21,142 (251)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies

Nature Communications, 2023
The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7
Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean de la Bâtie, Stéphanie Pons, Gabriel Ayme, Patrick England, Marc Gielen, François Bontems, Gérard Pehau-Arnaudet, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer   +11 more
doaj   +1 more source

Neurotensin Agonist Attenuates Nicotine Potentiation to Cocaine Sensitization [PDF]

Behavioral Sciences, 2014
Tobacco usage typically precedes illicit drug use in adolescent and young adult populations. Several animal studies suggest nicotine increases the risk for subsequent cocaine abuse, and may be a negative prognostic factor for treatment of cocaine addiction; i.e., a “gateway drug”. Neurotensin (NT) is a 13-amino acid neuropeptide that modulates dopamine,
Bethany Stennett, Paul A. Fredrickson, Mona Boules, Elliott Richelson   +3 more
openaire   +4 more sources

Making America Healthy Again: Remedies for Robert F. Kennedy Jr.'s Campaign against Chronic Disease

Hastings Center Report, EarlyView.
Abstract Chronic diseases impose enormous health and economic burdens in the United States, especially on marginalized populations, and demand evidence‐based, equity‐focused interventions. To combat chronic disease, the Trump administration established the Make America Healthy Again Commission, chaired by Department of Health and Human Services ...
Lawrence O. Gostin, Alexandra Finch, Peter Lurie   +2 more
wiley   +1 more source

Maternal gut microbiota‐derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure

iMeta, EarlyView.
Prenatal prednisone therapy (PPT)/prenatal prednisone exposure (PPE) induces long bone dysplasia, reduced peak bone mass (PBM), and increased osteoporosis susceptibility in female offspring. Maternal gut microbiota metabolite daidzein (DAI) mediates PPE‐induced osteoporosis susceptibility in female adult offspring.
Chi Ma, Hangyuan He, Kunpeng Wang, Juanjuan Guo, Liang Liu, Yuting Chen, Bin Li, Hao Xiao, Xufeng Li, Xiaoqian Lu, Tingting Wang, Yinxian Wen, Hui Wang, Liaobin Chen   +13 more
wiley   +1 more source

Evidence Regarding E‐Cigarettes as a Harm Reduction Strategy and Treatment for E‐Cigarette Cessation: An Overview and Guide for Clinicians

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, EarlyView.
ABSTRACT Since their emergence on the United States market in the early 2000s, e‐cigarette accessibility and use have grown considerably. Electronic cigarettes (e‐cigarettes), also referred to as vapes or electronic nicotine delivery systems, deliver their contents by heating and aerosolizing an “e‐liquid” that is then inhaled.
Kirk E. Evoy, Elizabeth S. Yett, Olivia Ramey, Nicole Lodise   +3 more
wiley   +1 more source

High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor. [PDF]

PLoS ONE, 2016
High throughput random mutagenesis is a powerful tool to identify which residues are important for the function of a protein, and gain insight into its structure-function relation.
Paul J Groot-Kormelink, Sandrine Ferrand, Nicholas Kelley, Anke Bill, Felix Freuler, Pierre-Eloi Imbert, Anthony Marelli, Nicole Gerwin, Lucia G Sivilotti, Loren Miraglia, Anthony P Orth, Edward J Oakeley, Ulrich Schopfer, Sandra Siehler   +13 more
doaj   +1 more source

Antiamnesic activity of the nicotinic agonist DBO-83 in mice [PDF]

Drug Development Research, 1998
The effect of administration of DBO-83 on memory processes was evaluated in the mouse passive avoidance test. DBO-83 (1–5 mgkg–1 ip) prevented amnesia induced by scopolamine (1.5 mgkg–1 ip), mecamylamine (20 mgkg–1 ip) and dihydro-β-erythroidine (10 μg per mouse i.c.v.). In the same experimental conditions, DBO-83 (10 mgkg–1 ip) also prevented baclofen
GHELARDINI, CARLA, GALEOTTI, NICOLETTA, F. GIULIANI, D. BARLOCCO, BARTOLINI, ALESSANDRO   +4 more
openaire   +3 more sources

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Stromal cell‐derived factor‐1 regulates expression of vascular endothelial growth factor and osteopontin after tooth extraction

Journal of Periodontology, EarlyView.
Abstract Background The present study aimed to investigate the expression of stromal cell‐derived factor‐1 (SDF‐1) after tooth extraction in rats and its regulatory effect on the expression of osteopontin (OPN) and vascular endothelial growth factor (VEGF).
Jingjing Kong, Lei Li, Fei Gao, Kaiqi Zhang, Jianli Xie, Jun Cui   +5 more
wiley   +1 more source