Results 111 to 120 of about 32,658 (245)

Nicotinic receptors [PDF]

, 2014
Regulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including ...
A Auclair, A Beyeler, A Coppen, A Dahlstrom, A Fletcher, A Fletcher, A Gobert, A Jain, A Markou, A Pazos, AC Farley, AJ Grottick, AJ Grottick, AM Batman, AS Brown, AV Prochazka, B Chang, B Lendvai, BB Brodie, BL Jacobs, BM Twarog, BR Cooper, C Cirillo, C Nocjar, C Reperant, CP Müller, D Herve, D Hoyer, D Hoyer, D Kooy van der, D Quarta, DE Nichols, DJ Balfour, DJ Hayes, DL Murphy, DL Willins, DM Tomkins, DV Herin, E Costa, E Esposito, E Quattrocki, EB Ribeiro, EC Azmitia, ED Levin, ED Levin, EJ Bockstaele Van, EJ Bockstaele Van, EJ Mills, F Jenck, G Chevalier, G Chiara Di, G Cucchiaro, G Cucchiaro, G Engberg, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Giovanni Di, G Porras, G Porras, GA Higgins, GA Higgins, GA Higgins, GA Kennett, GA Kennett, GF Koob, GW Dalack, H Khalki, H Moukhles, H Rollema, H Rollema, H Rollema, H Takahashi, HD Mansvelder, J Arnt, J Dong, J Hannon, JA Ascher, JE Anderson, JE Slemmer, JF Cryan, JH Thompson, JK Abrams, JL Neisewander, JR Martin, JW Coe, K Guillem, K Touiki, KD Alex, KG Baker, KH Thomas, KJ Clemens, KL Summers, L Galindo-Charles, L Pozzi, LA Pockros, LL McMahon, M Bubser, M Costa, M Dols, M Giorgetti, M Pierucci, M Pompeiano, M Reuben, M Zaniewska, M Zaniewska, M Zaniewska, MD Doherty, ME Benwell, MF O'Neill, MJ Bubar, MJ Bubar, MJ Eisenberg, MJ Millan, MM Rapport, N Corvaja, N Maurice, NA Rigotti, NB Edwards, NG Schneider, NM Barnes, OT Phillipson, P Deurwaerdere De, P Deurwaerdere De, P Enkhbaatar, P Olausson, P Olausson, P Seth, PA Crooks, PBS Clarke, PH Hutson, PJ Fletcher, PJ Fletcher, PJ Fletcher, PJ Kenny, PJ Kenny, PM Whitaker-Azmita, RD Schwartz, RF Mucha, RM Bowker, RM Bowker, RS Bitner, RS Bitner, S Hjorth, S Mihailescu, S Navailles, S Prisco, SG Matta, SJ Bonasera, SM Hall, SM Hall, SP Ji, SP Ranade, TA Shahan, V Cornea-Hébert, V Erspamer, V Hillegaart, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, V Matteo Di, W Feldberg, WA Corrigall, X Li, Y Takada, Z Ma, ZJ Yu   +173 more
core   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens [PDF]

, 2004
The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Beato, M., Burzomato, V., Colquhoun, D., Groot-Kormelink, P.J., Sivilotti, L.G.   +4 more
core  

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Mechanical properties of the compass depressors of the sea-urchin Paracentrotus lividus (Echinodermata, Echinoidea) and the effects of enzymes, neurotransmitters and synthetic tensilin-like protein.

PLoS ONE, 2015
The compass depressors (CDs) of the sea-urchin lantern are ligaments consisting mainly of discontinuous collagen fibrils associated with a small population of myocytes. They are mutable collagenous structures, which can change their mechanical properties
Iain C Wilkie, Dario Fassini, Emanuele Cullorà, Alice Barbaglio, Serena Tricarico, Michela Sugni, Luca Del Giacco, M Daniela Candia Carnevali   +7 more
doaj   +1 more source

Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases

Neural Regeneration Research, 2017
Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's diseases, are all characterized by a component of innate immunity called neuroinflammation. Neuronal loss and neuroinflammation are two phenomena closely linked.
Laura Foucault-Fruchard, Daniel Antier
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

New Therapeutic Approaches for the Treatment of Rheumatoid Arthritis may Rise from the Cholinergic Anti-Inflammatory Pathway and Antinociceptive Pathway

The Scientific World Journal, 2010
Due to the complex etiology of rheumatoid arthritis (RA), it is difficult to be completely cured at the current stage although many approaches have been applied in clinics, especially the wide application of nonsteroidal anti-inflammatory drugs (NSAIDs ...
Xiao Hua Pan, Jianxin Zhang, Xiaowei Yu, Ling Qin, Ligeng Kang, Peng Zhang   +5 more
doaj   +1 more source