Results 171 to 180 of about 30,934 (191)

Epibatidine, a potent analgetic and nicotinic agonist.

Molecular Pharmacology, 1994
Synthetic (+)- and (-)-epibatidine (an alkaloid originally characterized from frog skin) have potent analgetic activity in mice, using the hot-plate assay. The natural (+)-enantiomer, with an ED50 of about 1.5 micrograms/kg upon intraperitoneal injection, is about 2-fold more potent than the (-)-enantiomer.
B, Badio, J W, Daly
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Discriminative stimulus properties of the nicotinic agonist cytisine

Psychopharmacology, 1997
Cytisine binds with high affinity and specificity to neuronal nicotinic receptors but its physiological and behavioural effects are complex and differ from those of nicotine. The present study explores the behavioural aspects further by comparing the discriminative stimulus effects of cystisine with those of nicotine. Two groups of rats were trained to
Chris Chandler, I.P. Stolerman
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Neuronal nicotinic acetylcholine receptor agonists

Expert Opinion on Therapeutic Patents, 2004
Nicotinic acetylcholine receptors (nAChRs) consist of five protein subunits surrounding a central ion channel.
TOMA, LUCIO, BARLOCCO Daniela, GELAIN Arianna   +2 more
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ABT — 418, a Novel Nicotinic Agonist

1994
With the plethora of receptor targets evolving as the result of nicotinic acetylcholine receptor (nAChR) cloning it is possible that new molecular entities selective for subtypes of nAChRs can be developed which are potentially free of the side effect liabilities associated with (-)-nicotine.
Jorge D. Brioni, M. W. Decke, Yvonne C. Martin, S. P. Amend, David J. Anderson, James R. Pauly, M. J. Buckley, J. T. Wasicak, A. D. Rodrigues, James R. Pauly, P. A. Pavlik, Michael W. Decker, David S. Garvey, M. Majchrzak, Diana L. Donnelly-Roberts, Stephen P. Arneric, Alyssa B. O'Neill, Mark W. Holladay, Richard J. Radek, Jerry J. Buccafusco, Alvin V. Terry, Scott F. Robinson, D. J. B. Kim, Peter Curzon, James P. Sullivan, K. C. Marsh, Susan Wonnacott, William J. Jackson, G. Wilkie, S C Quigley, Kennan C. Marsh, Michael Williams   +31 more
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NICOTINIC AGONIST MODULATION OF FELINE BRONCHOMOTOR TONE

Clinical and Experimental Pharmacology and Physiology, 1990
SUMMARY1. The bronchomotor actions of three nicotinic cholinoceptor agonists were investigated in anaesthetized, mechanically ventilated cats. The agonists were administered intravenously after increasing baseline airways smooth muscle tone with an infusion of 5‐hydroxytryptamine.2.
Louis Diamond, Ralph J. Altiere, David C. Thompson   +2 more
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Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists.

Ciba Foundation symposium, 1990
Although numerous studies have demonstrated that chronic nicotine treatment often results in tolerance to this drug, the mechanisms that underlie this tolerance are not well defined. Recent evidence suggests that chronic nicotine treatment results in an up-regulation of brain nicotinic receptors, but the majority of these receptors may be desensitized ...
James R. Pauly, Michael J. Marks, Ratan V. Bhat, Allan C. Collins   +3 more
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Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.

The Journal of Pharmacology and Experimental Therapeutics, 1996
The present experiments assessed the influence of nicotinic cholinergic receptors on latent inhibition (LI), which is the decrement in Pavlovian conditioning resulting from extensive preexposure to a conditioned stimulus (CS). LI was assessed within a conditioned emotional response paradigm involving three phases: preexposure [either 0 (nonpreexposed ...
J, Rochford, A P, Sen, R, Quirion
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HM74a Agonists: Will they be the New Generation of Nicotinic Acid?

Current Topics in Medicinal Chemistry, 2009
The discovery of HM74a as a high affinity receptor for nicotinic acid has opened up new areas for investigation. Since its discovery, several new chemical entities have been reported as HM74a agonists. One of them, MK-0354, has been tested in phase II studies, but despite significant decreases in Free Fatty Acid levels with absence of flushing events ...
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Effects of isoarecolone, a nicotinic receptor agonist in rodent models of nicotine dependence

Psychopharmacology, 2006
The nicotinic receptor agonist, isoarecolone, has 'nicotine-like' subjective properties as detected by rats in a discrimination paradigm. However, isoarecolone lacks the intra-accumbens dopamine-releasing effects, a feature akin to most abused substances.
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Nicotine receptor partial agonists for alcohol dependence

Cochrane Database of Systematic Reviews, 2011
Reason for withdrawal from publication This protocol is withdrawn because authors did not find time to finish the review within adequate deadlines.
Susanna Galea, David Newcombe, Jane Sheridan, Natalie Walker, Jonathan Williman, Hayden McRobbie   +5 more
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