Results 81 to 90 of about 33,509 (296)

Neurotensin Agonist Attenuates Nicotine Potentiation to Cocaine Sensitization [PDF]

Behavioral Sciences, 2014
Tobacco usage typically precedes illicit drug use in adolescent and young adult populations. Several animal studies suggest nicotine increases the risk for subsequent cocaine abuse, and may be a negative prognostic factor for treatment of cocaine addiction; i.e., a “gateway drug”. Neurotensin (NT) is a 13-amino acid neuropeptide that modulates dopamine,
Bethany Stennett, Paul A. Fredrickson, Mona Boules, Elliott Richelson   +3 more
openaire   +4 more sources

Making America Healthy Again: Remedies for Robert F. Kennedy Jr.'s Campaign against Chronic Disease

Hastings Center Report, EarlyView.
Abstract Chronic diseases impose enormous health and economic burdens in the United States, especially on marginalized populations, and demand evidence‐based, equity‐focused interventions. To combat chronic disease, the Trump administration established the Make America Healthy Again Commission, chaired by Department of Health and Human Services ...
Lawrence O. Gostin, Alexandra Finch, Peter Lurie   +2 more
wiley   +1 more source

Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors. [PDF]

PLoS ONE, 2013
Subtype-selective ligands are important tools for the pharmacological characterisation of neurotransmitter receptors. This is particularly the case for nicotinic acetylcholine receptors (nAChRs), given the heterogeneity of their subunit composition.
JasKiran K Gill, Anna Chatzidaki, Daniel Ursu, Emanuele Sher, Neil S Millar   +4 more
doaj   +1 more source

Evidence Regarding E‐Cigarettes as a Harm Reduction Strategy and Treatment for E‐Cigarette Cessation: An Overview and Guide for Clinicians

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, EarlyView.
ABSTRACT Since their emergence on the United States market in the early 2000s, e‐cigarette accessibility and use have grown considerably. Electronic cigarettes (e‐cigarettes), also referred to as vapes or electronic nicotine delivery systems, deliver their contents by heating and aerosolizing an “e‐liquid” that is then inhaled.
Kirk E. Evoy, Elizabeth S. Yett, Olivia Ramey, Nicole Lodise   +3 more
wiley   +1 more source

Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors

Anais da Academia Brasileira de Ciências, 2002
Several neurotransmitter systems have been related to developmental processes during the past decade. In this review, we discuss the evidence that the nicotinic acetylcholine receptors could have an additional function during development that may be ...
TORRÃO ANDRÉA S., BRITTO LUIZ R.G.
doaj  

A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site [PDF]

, 2004
To study conformational transitions at the muscle nicotinic acetylcholine (ACh) receptor (nAChR), a rhodamine fluorophore was tethered to a Cys side chain introduced at the beta-19' position in the M2 region of the nAChR expressed in Xenopus oocytes ...
Auyeung, Vincent C., Bezanilla, Francisco, Chanda, Baron, Dahan, David S., Dibas, Mohammed I., Dougherty, Dennis A., Lester, Henry A., Petersson, E. James   +7 more
core  

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Cholinergic calcium responses in cultured antennal lobe neurons of the migratory locust

Scientific Reports, 2021
Locusts are advantageous organisms to elucidate mechanisms of olfactory coding at the systems level. Sensory input is provided by the olfactory receptor neurons of the antenna, which send their axons into the antennal lobe. So far, cellular properties of
Gregor A. Bergmann, Gerd Bicker
doaj   +1 more source

Antiamnesic activity of the nicotinic agonist DBO-83 in mice [PDF]

Drug Development Research, 1998
The effect of administration of DBO-83 on memory processes was evaluated in the mouse passive avoidance test. DBO-83 (1–5 mgkg–1 ip) prevented amnesia induced by scopolamine (1.5 mgkg–1 ip), mecamylamine (20 mgkg–1 ip) and dihydro-β-erythroidine (10 μg per mouse i.c.v.). In the same experimental conditions, DBO-83 (10 mgkg–1 ip) also prevented baclofen
GHELARDINI, CARLA, GALEOTTI, NICOLETTA, F. GIULIANI, D. BARLOCCO, BARTOLINI, ALESSANDRO   +4 more
openaire   +3 more sources

Stromal cell‐derived factor‐1 regulates expression of vascular endothelial growth factor and osteopontin after tooth extraction

Journal of Periodontology, EarlyView.
Abstract Background The present study aimed to investigate the expression of stromal cell‐derived factor‐1 (SDF‐1) after tooth extraction in rats and its regulatory effect on the expression of osteopontin (OPN) and vascular endothelial growth factor (VEGF).
Jingjing Kong, Lei Li, Fei Gao, Kaiqi Zhang, Jianli Xie, Jun Cui   +5 more
wiley   +1 more source