Results 111 to 120 of about 57,977 (335)
The surface accessibility of α-bungarotoxin monitored by a novel paramagnetic probe [PDF]
The surface accessibility of {\alpha}-bungarotoxin has been investigated by using Gd2L7, a newly designed paramagnetic NMR probe. Signal attenuations induced by Gd2L7 on {\alpha}-bungarotoxin C{\alpha}H peaks of 1H-13C HSQC spectra have been analyzed and compared with the ones previously obtained in the presence of GdDTPA-BMA. In spite of the different
arxiv
Abstract Background Chronic kidney disease (CKD) has a high prevalence in patients with heart failure (HF) and is associated with prolonged hospitalization, increased need for intensive care and mortality. There is an urgent need to identify factors that influence the interaction between heart and kidney disorders, often described as cardiorenal ...
Alexander Reinecke+7 more
wiley +1 more source
The reductive hydroformylation of linseed oil was carried out using a rhodium precursor associated with various nitrogen derivatives such as pyridines, imidazoles, trialkylamines, amidines, and guanidines. ABSTRACT The reductive hydroformylation reaction of polyunsaturated linseed oil using a rhodium precursor associated with a nitrogen compound from ...
Walid Abdallah+9 more
wiley +1 more source
Abstract Objective: Estimate the prevalence of e‐cigarette use (vaping) among Aboriginal and Torres Strait Islander adolescents and explore the relationship between vaping and tobacco use. Methods: N=18,199 students aged 12–17 years (n=1,097 Aboriginal and Torres Strait Islander) participating in the 2017 Australian Secondary Students’ Alcohol and Drug
Christina Heris+3 more
wiley +1 more source
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration, and effective Hill coefficient, and explore the full spectrum
arxiv
Nitrosamines as nicotinic receptor ligands [PDF]
Nitrosamines are carcinogens formed in the mammalian organism from amine precursors contained in food, beverages, cosmetics and drugs. The potent carcinogen, NNK, and the weaker carcinogen, NNN, are nitrosamines formed from nicotine. Metabolites of the nitrosamines react with DNA to form adducts responsible for genotoxic effects. We have identified NNK
openaire +3 more sources
Recent Advances in the α‐Hydrazination (α‐Amination) of Carbonyl Compounds
In recent years, notable progress has been achieved in the α‐hydrazination (α‐amination) of carbonyl compounds, especially in the direct asymmetric electrophilic α‐hydrazination with dialkyl azodicarboxylates. This review summarizes all the methods that appeared over the past decade, categorized based on the type of the reactive chiral intermediate ...
Dina Scarpi+2 more
wiley +1 more source
Vaping product access and use among 14–17‐year‐olds in New South Wales: a cross‐sectional study
Abstract Objectives: We assessed access to vaping products and types of products used and the factors associated with vaping and smoking among young people in the state of New South Wales (NSW), Australia. Methods: A cross‐sectional survey was conducted with a sample of 721 young people aged 14 to 17 years from NSW recruited through online panels ...
Christina Watts+6 more
wiley +1 more source
Impaired neurovascular coupling in the APPxPS1 mouse model of Alzheimerâs disease [PDF]
The tight coupling between neuronal activity and the local increase of blood flow termed neurovascular coupling is essential for normal brain function. This mechanism of regulation is compromised in Alzheimer's Disease (AD). In order to determine whether a purely vascular dysfunction or a neuronal alteration of blood vessels diameter control could be ...
arxiv