Results 81 to 90 of about 91,243 (276)

A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]

, 2005
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo, Azam, Baker, Balestra, Bleckmann, Bobbin, Boulter, Cartier, Champtiaux, Chernyavsky, Colquhoun, Conroy, Couturier, Dawkins, Deneris, Drescher, Duvoisin, Elgoyhen, Elgoyhen, Engelmann, Flock, Fuchs, Genzen, Gerzanich, Gerzanich, Glowatzki, Goldman, Gotti, Gotti, Groot-Kormelink, Guinan, Haberberger, Jones, Karlin, Katz, Katz, Kros, Kurzen, Le Novere, Lips, Luebke, Lustig, McIntosh, McIntosh, Mihovilovic, Morley, Nguyen, Nicke, Peng, Pohlmann, Rothlin, Russell, Santos, Sato, Seguela, Sgard, Terlau, Walker, Wals, Weisstaub   +59 more
core   +1 more source

Patterns of Nicotinic Receptor Antagonism: Nicotine Discrimination Studies [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2011
Evaluation of the discriminative stimulus effects of drugs is a useful procedure for identification of receptor mediation of in vivo drug effects. This assay can be enhanced when the stimulus effects of different doses of agonist are evaluated. In the present study, rats were trained to discriminate small or large doses of nicotine from saline, and ...
Emily M, Jutkiewicz, Emily A, Brooks, Adam D, Kynaston, Kenner C, Rice, James H, Woods   +4 more
openaire   +2 more sources

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Nicotine Addiction: Neurobiology and Mechanism

Journal of Pharmacopuncture, 2020
Nicotine, primary component of tobaco produces craving and withdrawal effect both in humans and animals. Nicotine shows a close resemblance to other addictive drugs in molecular, neuroanatomical and pharmacological, particularly the drugs which enhances ...
Raj Kumar Tiwari, Vikas Sharma, Ravindra Kumar Pandey, Shiv Shankar Shukla   +3 more
doaj   +1 more source

Prenatal Nicotine Exposure as a Teratogen in Neurological Pathways [PDF]

, 2016
Attention-deficit/hyperactivity disorder (ADHD) is the most heritable and commonly diagnosed childhood psychiatric disorder with 4% of all children being diagnosed with this disorder.
Grover, Monica
core   +1 more source

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]

, 2016
Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

Evaluation of the cholinomimetic actions of trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana (Gastropoda, Opisthobranchia)

Brazilian Journal of Medical and Biological Research, 2002
Trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana, negatively modulates vagal response, indicating a probable ability to inhibit cholinergic responses.
C.M. Kerchove, R.P. Markus, J.C. Freitas, L.V. Costa-Lotufo   +3 more
doaj   +1 more source

Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]

, 2016
Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core   +1 more source

Differential roles of EA‐TRAPed cells in the anterior cingulate cortex across various intervention times in inflammatory pain

Animal Models and Experimental Medicine, EarlyView.
The cumulative effect of EA analgesia is partially attributed to the activation of EA‐TRAPed cells in ACC. Multiple EA sessions and single EA sessions activated different neuronal populations in the ACC. The enhanced analgesic effect of multiple EA sessions may be attributed to an increase in the proportion of GABAergic neurons within the ACC. Abstract
Zi Guo, Ru Ye, Lu Guan, Wei He, Shuang Qiu, Xiaomei Shao, Junfan Fang, Jianqiao Fang, Junying Du   +8 more
wiley   +1 more source