Results 131 to 140 of about 93,808 (329)

Evolution of infarct size during the early use of nifedipine in patients with acute myocardial infarction: the Norwegian Nifedipine Multicenter Trial. [PDF]

open access: bronze, 1984
Per Anton Sirnes   +9 more
openalex   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm   +3 more
wiley   +1 more source

Presynaptic quantal size enhancement counteracts post‐tetanic release depression

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sustained high‐frequency stimulation decreases the number of synaptic vesicles that fuse per action potential at the Drosophila neuromuscular junction. However, the postsynaptic response remains largely unchanged. An increased postsynaptic response to individual vesicles, likely driven by an increase in vesicle size resulting ...
Anu G. Nair   +5 more
wiley   +1 more source

TOXICOLOGICAL STUDY OF MEBUDIPINE AND DIBUDINE, TWO NEW CALCIUMCHANNEL BLOCKERS, IN SACCHAROMYCES CERVISES AND ISOLATED RAT HEPATOCYTES CELLS INVITRO [PDF]

open access: yes
Mebudipine and Dibudipine are two new calcium antagosists used in laboratory animals. Toxicological testing were evaluated in cultured mouse cells in‐vitro and on growth yeast cells . It is shown that in these two system it is safe and no toxicological
بهلولی, شهاب   +4 more
core  

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger   +4 more
wiley   +1 more source

A randomized placebo-controlled study on the effect of nifedipine on coronary endothelial function and plaque formation in patients with coronary artery disease: the ENCORE II study [PDF]

open access: yes, 2017
Aims Endothelial dysfunction and plaque formation are features of atherosclerosis. Inhibition of L-type calcium channels or HMG-CoA pathway improves endothelial function and reduces plaque size.
Bischoff, Karl-Otto   +11 more
core  

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti   +2 more
wiley   +1 more source

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