Results 51 to 60 of about 3,048,198 (365)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The dynamic nature and territory of transcriptional machinery in the bacterial chromosome

Frontiers in Microbiology, 2015
Our knowledge of the regulation of genes involved in bacterial growth and stress responses is extensive; however, we have only recently begun to understand how environmental cues influence the dynamic, three-dimensional distribution of RNA polymerase ...
Ding Jun Jin, Cedric eCagliero, Carmen eMata Martin, Jerome eIzard, Yan Ning eZhou   +4 more
doaj   +1 more source

NIH Funding for Surgeon-Scientists in the US: What Is the Current Status?

Journal of the American College of Surgeons, 2020
BACKGROUND Recent literature suggests the future of surgeon scientists in the United States has been significantly threatened for the past several decades.
Lindsay A. Demblowski, B. Busse, George M. Santangelo, A. Blakely, Patricia L. Turner, D. Hoyt, M. Zeiger   +6 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

C57BL/6 life span study: age-related declines in muscle power production and contractile velocity [PDF]

, 2015
Quantification of key outcome measures in animal models of aging is an important step preceding intervention testing. One such measurement, skeletal muscle power generation (force * velocity), is critical for dynamic movement.
Graber, Ted G., Grange, Robert W., Kim, Jong-Hee, McLoon, Linda K., Thompson, LaDora V.   +4 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

High-density Lipoproteins and Apolipoprotein A-I: Potential New Players in the Prevention and Treatment of Lung Disease

Frontiers in Pharmacology, 2016
Apolipoprotein A-I (apoA-I) and high-density lipoproteins (HDL) mediate reverse cholesterol transport out of cells. Furthermore, HDL has additional protective functions, which include anti-oxidative, anti-inflammatory, anti-apoptotic, and vasoprotective
Elizabeth M. Gordon, Debbie M. Figueroa, Amisha V. Barochia, Xianglan Yao, Stewart J. Levine   +4 more
doaj   +1 more source

Emergent simplicity in microbial community assembly [PDF]

, 2018
Published in final edited form as: Science. 2018 August 03; 361(6401): 469–474. doi:10.1126/science.aat1168.A major unresolved question in microbiome research is whether the complex taxonomic architectures observed in surveys of natural communities can ...
Bajic, Djordje, Estrela, Sylvie, Goldford, Joshua E., Lu, Nanxi, Mehta, Pankaj, Sanchez, Alvaro, Sanchez-Gorostiaga, Alicia, Segre, Daniel, Tikhonov, Mikhail   +8 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Variable responses of human and non-human primate gut microbiomes to a Western diet [PDF]

, 2015
BACKGROUND: The human gut microbiota interacts closely with human diet and physiology. To better understand the mechanisms behind this relationship, gut microbiome research relies on complementing human studies with manipulations of animal models ...
Amato, Katherine R., Cerda, Gabriela, Cramer, Jennifer Danzy, Gomez, Andres, Knight, Rob, Leigh, Steven R., Miller, Margret E. Berg, Nelson, Karen E., Schmitt, Christopher A., Stumpf, Rebecca M., Turner, Trudy R., White, Bryan A., Wilson, Brenda A., Yeoman, Carl J.   +13 more
core   +5 more sources