Results 71 to 80 of about 6,837 (257)

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Microbial Community and in situ Bioremediation of Groundwater by Nitrate Removal in the Zone of a Radioactive Waste Surface Repository

Frontiers in Microbiology, 2018
The goal of the present work was to investigate the physicochemical and radiochemical conditions and the composition of the microbial community in the groundwater of a suspended surface repository for radioactive waste (Russia) and to determine the ...
Alexey V. Safonov, Alexey V. Safonov, Tamara L. Babich, Diyana S. Sokolova, Denis S. Grouzdev, Tatiyana P. Tourova, Andrey B. Poltaraus, Elena V. Zakharova, Elena V. Zakharova, Alexander Y. Merkel, Alexander P. Novikov, Tamara N. Nazina, Tamara N. Nazina   +12 more
doaj   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

The Regulation of Nitrate Reductases in Response to Abiotic Stress in Arabidopsis. [PDF]

Int J Mol Sci, 2022
Tang X, Peng Y, Li Z, Guo H, Xia X, Li B, Yin W.   +6 more
europepmc   +1 more source

Heavy Metal Contamination: Impacts From Plants to the Food Chain and Eco‐Friendly Amelioration Strategies

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Heavy metal pollution reduces soil health and threatens food safety by entering plants; however, the use of nanoparticles, biofertilizers, and organic fertilizers such as biochar offers a promising strategy for improvement and sustainable agriculture. ABSTRACT Heavy metal (HM) pollution, resulting from human activities such as mining and the excessive ...
Sina Siavash Moghaddam, Latifeh Pourakbar, Sevda Alizadeh, Zahra Alizadeh, Jelena Popović‐Djordjević   +4 more
wiley   +1 more source

Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA.

PLoS Genetics, 2015
The assimilation of nitrate, a most important soil nitrogen source, is tightly regulated in microorganisms and plants. In Aspergillus nidulans, during the transcriptional activation process of nitrate assimilatory genes, the interaction between the ...
Andreas Gallmetzer, Lucia Silvestrini, Thorsten Schinko, Bernd Gesslbauer, Peter Hortschansky, Christoph Dattenböck, María Isabel Muro-Pastor, Andreas Kungl, Axel A Brakhage, Claudio Scazzocchio, Joseph Strauss   +10 more
doaj   +1 more source

Host‐Specific Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa Impair Epithelial Repair in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is frequently associated with polymicrobial biofilms involving Staphylococcus aureus and Pseudomonas aeruginosa. Interactions between these organisms are thought to influence disease severity, but the epithelial effects of exoproteins derived from patient‐matched cocultures remain poorly defined ...
Xiaohan Sun, Mahnaz Ramezanpour, George Bouras, Emma Barry, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +6 more
wiley   +1 more source

The dual interplay of RAV5 in activating nitrate reductases and repressing catalase activity to improve disease resistance in cassava. [PDF]

Plant Biotechnol J, 2021
Yan Y, Wang P, Wei Y, Bai Y, Lu Y, Zeng H, Liu G, Reiter RJ, He C, Shi H.   +9 more
europepmc   +1 more source

Metagenomic potential for and diversity of N‐cycle driving microorganisms in the Bothnian Sea sediment

MicrobiologyOpen, 2017
The biological nitrogen cycle is driven by a plethora of reactions transforming nitrogen compounds between various redox states. Here, we investigated the metagenomic potential for nitrogen cycle of the in situ microbial community in an oligotrophic ...
Olivia Rasigraf, Julia Schmitt, Mike S. M. Jetten, Claudia Lüke   +3 more
doaj   +1 more source