Results 141 to 150 of about 646,019 (403)

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

Advanced Science, EarlyView.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li, Fulong Man, Jianwei Cheng, Li Chen, Yongyong Li, Haiqing Dong   +5 more
wiley   +1 more source

Protective Effect of Aerobic Exercise against Some of Proinflammatory Cytokines-Induced Chronic Nitric Oxide Synthase Inhibition in Renal Tissue Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2013
BACKGROUND AND OBJECTIVE: Hypertension is associated with alteration in endothelial function mediated through reduced nitric oxide bioavailability and renal injury.
M Habibian,, M Peeri, MA Azarbayjani,, M Hedayati   +3 more
doaj  

Differential Expression of Inducible Nitric Oxide Synthase in Septic Shock [PDF]

, 1999
Don B. Sanders, Douglas F. Larson, Curt Jablonowski, Laura Olsen   +3 more
openalex   +1 more source

Macrophage‐Targeted Magnesium Ion‐Nourisher for NLRP3 Inflammasome Inhibition to Enhance Liver Inflammatory Disease Treatment

Advanced Science, EarlyView.
This report describes a nano magnesium nourisher, named MgC@PS, capable of targeted Mg2⁺ delivery to macrophages, effectively suppressing The nuclear factor kappa B (NF‐κB) activation and mitigating NLRP3 inflammasome‐driven pyroptosis in liver inflammation.
Li Wang, Zhuo Yan, Sindhu Yalavarthi, Yusif Abdul‐Rashid, Kiki Parker, Kyle Nowlin, Ethan Li, Jordan Mack, Josephine Wei, Hunter Vu, Zhenquan Jia, Jianjun Wei, Jilong Wang, Kerui Wu   +13 more
wiley   +1 more source

Neuroprotection and Axonal Regeneration via ECM‐Mimetic Nanofibers Incorporating Metal–Phenolic Network Nanoparticles Toward Spinal Cord Injury Repair

Advanced Science, EarlyView.
Metal–phenolic network (MPN) nanoparticles with neuroprotective functions are integrated into decellularized extracellular matrix (dECM) to obtain biomimetic composite fibrous scaffold MPN@dECM NFs by electrospinning, which protects spared neurons from secondary degeneration by suppressing excitotoxicity and inflammation, and promotes directional ...
Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu, Xi Chen   +4 more
wiley   +1 more source

Structural and Electronic Complexities of a Sulfur‐Bridged Di‐Iron Complex Composed of Mono‐ and Di‐Nitrosyl Units

Advanced Science, EarlyView.
Two NO‐containing iron units, biologically relevant as NO storage/release centers, connected by sulfur, display characteristics arising from multiple quantum levels in their extensively delocalized arrangement. Analysis in three charge levels finds the electron distribution almost substantially spread over all atoms of its composition: 2S, 2Fe, and 3NO.
Sarnali Sanfui, Manuel Quiroz, Jialu Li, Yang Ha, Feipeng Yang, Jinghua Guo, Nattamai Bhuvanesh, Brad S. Pierce, Perla B. Balbuena, Paul A. Lindahl, Michael B. Hall, Marcetta Y. Darensbourg   +11 more
wiley   +1 more source

A computational model for analysis of uncoupled NO synthase on nitric oxide and superoxide interaction in microcirculation [PDF]

, 2007
Nitric oxide (NO) produced by endothelial cells is a key component for blood-vessel dilation. Dilation is achieved through smooth muscle relaxation as a response to NO transport.
Kavdia, Mahendra, Richardson, William
core   +2 more sources

Direct Evidence for Nitric Oxide Production by a Nitric-oxide Synthase-like Protein from Bacillus subtilis [PDF]

, 2002
Subrata Adak, Kulwant S. Aulak, Dennis J. Stuehr   +2 more
openalex   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes [PDF]

, 2007
Salvatore Cuzzocrea, Daniela Salvemini
openalex   +1 more source