Cellular Physiology and Biochemistry, 2014 Aims: Effect and mechanism of Yulangsan flavonoid (YLSF) on rat myocardial ischemia/reperfusion injury (MI/RI) has been investigated. Methods: Sprague-Dawley (SD) rats were randomly divided into seven groups (sham group, model group and NS group: 2 mL of
Xudong Zhang +9 more
doaj +1 more source
Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy
Advanced Science, EarlyView.Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley +1 more source
Sexual Abstinence and Immobilisation Stress Decreased Nitrate + Nitrite Concentration and Increased Necrotic of Penile Corpus Cavernosum Smooth Muscle and Endothelial Cells of Adult Male Mice [PDF]
, 2010 Sexual intercourse in adult people is not only related to reproduction,recreation and better relation but also for maintaining good health. Regular andfrequent sexual intercourse has protective role for cardiovascular disease, Malignancyand often related
Karmaya, I. N. (I) +2 more
core
Nitric oxide production by Biomphalaria glabrata haemocytes: effects of Schistosoma mansoni ESPs and regulation through the extracellular signal-regulated kinase pathway [PDF]
, 2009 BACKGROUND: Schistosoma mansoni uses Biomphalaria glabrata as an intermediate host during its complex life cycle. In the snail, the parasite initially transforms from a miracidium into a mother sporocyst and during this process excretory-secretory ...
Davies, Angela J +4 more
core +3 more sources
Metabolic Programming Drives Protective and Inflammatory Monocyte Fates in Viral Encephalitis
Advanced Science, EarlyView.Bone marrow monocytes infiltrate the West Nile virus‐infected brain and differentiate into HIF1‐α⁺ monocyte‐derived cells (MCs) that diverge into protective, antigen‐presenting or inflammatory, iNOS⁺ MCs with distinct metabolic programs and functions.
Claire L. Wishart +4 more
wiley +1 more source
Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. [PDF]
, 1992 Charles J. Lowenstein +3 more
openalex +1 more source
Gating NO Release from Nitric Oxide Synthase [PDF]
, 2012 We have investigated the kinetics of NO escape from Geobacillus stearothermophilus nitric oxide synthase (gsNOS). Previous work indicated that NO release was gated at position 223 in mammalian enzymes; our kinetics experiments include mutants at that ...
Agapie, Theodor +6 more
core +1 more source
Advanced Science, EarlyView.Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,
Hao‐Xiang Yuan +10 more
wiley +1 more source
ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors
Advanced Science, EarlyView.This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang +14 more
wiley +1 more source
Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation
Advanced Science, EarlyView.PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng +23 more
wiley +1 more source