Results 261 to 270 of about 630,432 (401)

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

Ibrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka, Mariafrancesca Cascione, Paolo Pellegrino, Annalisa Bianco, Stefano Leporatti, Valeria De Matteis   +5 more
wiley   +1 more source

Advances in the Regulation of Inflammatory Mediators in Nitric Oxide Synthase: Implications for Disease Modulation and Therapeutic Approaches. [PDF]

Int J Mol Sci
Kim ME, Lee JS.
europepmc   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

, 1992
David S. Bredt, C D Ferris, Solomon H. Snyder   +2 more
openalex   +1 more source

Induction of inducible nitric oxide synthase expression in human secretory endometrium [PDF]

, 1998
Walter Tschugguel, C. Scheeberger, Gertrud Unfried, K. Czerwenka, W. Wenlnger, Michael Mildner, Joseph R. Bishop, J. Huber   +7 more
openalex   +1 more source

Magnesium Silicate Composite Patch With Neurovascular Regenerative Properties Promotes Diabetic Wound Healing in Mice

Interdisciplinary Materials, EarlyView.
The PCL‐PLLA‐MgSiO3 composite patch fabricated via electrospinning demonstrates superior therapeutic effects on diabetic wound healing compared to commercially available products, especially neurovascular network recovery. This will provide a promising bioactive patch for future clinical diabetic wound management.
Shunxiang Xu, Hongwei Shao, Zheyu Jin, Jiankun Xu, Fanyan Deng, Yuantao Zhang, Liangbin Zhou, Samuel Ka‐kin Ling, Congqin Ning, Wenxue Tong, Ling Qin   +10 more
wiley   +1 more source

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

, 1991
Ulrich Förstermann, Jennifer S. Pollock, Harald Schmidt, Michael J. Heller, Faris Murad   +4 more
openalex   +1 more source

Betaine protects cerebral microvascular endothelium and ameliorates hypertension-induced cognitive dysfunction via upregulation of the endothelial nitric oxide synthase/nitric monoxide signaling pathway. [PDF]

J Hypertens
Sun J, Zhang W, Wang X, Zhao X, Gao S.
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory ganglia, and olfactory epithelium

, 1994
David S. Bredt, Solomon H. Snyder
openalex   +1 more source