Results 261 to 270 of about 200,814 (309)

Endothelial Nitric Oxide Synthase

2011
Diabetic nephropathy remains a leading cause for end-stage renal disease indicating a failure of current therapeutic strategies. One factor that impairs our ability to make advances has been the inadequacy of most animal models in manifesting advanced diabetic renal disease.
Takahiko, Nakagawa, Richard J, Johnson
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Mitochondrial nitric oxide synthase

Mitochondrion, 2004
Nitric oxide (NO*) can bind to and inhibit the terminal enzyme of the mitochondrial respiratory chain, cytochrome c oxidase (complex IV). In vivo, NO* is made by the NO* synthase (NOS) family of enzymes, and considerable debate has recently arisen regarding a NOS inside mitochondria (termed 'mtNOS').
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Nitric Oxide Synthase Inhibitors

2003
In 1990, several studies reported that an enhanced formation of endogenous nitric oxide (NO) contributes to the hypotension caused by endotoxin and tumor-necrosis factor-α (TNFα) (1-3). In addition, it became apparent that this overproduction of NO also plays an important role in the pathophysiology of the vascular hyporesponsiveness to vasoconstrictor
D K, Siriwardena, H, Tagori, C, Thiemermann   +2 more
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Nitric Oxide Synthase Assays

Current Protocols in Pharmacology, 1998
AbstractNitric oxide (NO) is a widespread messenger molecule that regulates cardiovascular tone, immune responses, and neuronal function. This unit provides a simple protocol for measuring NO production based on the stoichiometric formation of the byproduct L‐citrulline by nitric oxide synthase (NOS) when NO is produced.
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Nitric oxide, nitric oxide synthase, and hypertensive vascular disease

Current Hypertension Reports, 1999
In normotension the endothelium produces mainly nitric oxide (NO) and prostacyclin, and the vasodilator and growth inhibitory influence predominates. Hypertension, however, is associated with a shift towards enhanced constriction and vascular hypertrophy.
R, Busse, I, Fleming
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Multimodality imaging of nitric oxide and nitric oxide synthases

Free Radical Biology and Medicine, 2009
Nitric oxide (NO) and NO synthases (NOSs) are crucial factors in many pathophysiological processes such as inflammation, vascular/neurological function, and many types of cancer. Noninvasive imaging of NO or NOS can provide new insights in understanding these diseases and facilitate the development of novel therapeutic strategies.
Hao, Hong, Jiangtao, Sun, Weibo, Cai
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Catalysis by nitric oxide synthase

Current Opinion in Chemical Biology, 1998
The enzyme nitric oxide synthase catalyzes the oxidation of the amino acid L-arginine to L-citrulline and nitric oxide in an NADPH-dependent reaction. Nitric oxide plays a critical role in signal transduction pathways in the cardiovascular and nervous systems and is a key component of the cytostatic/cytotoxic function of the immune system ...
M A, Marletta, A R, Hurshman, K M, Rusche   +2 more
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Nitric oxide and nitric oxide synthase activity in plants

Phytochemistry, 2004
Research on NO in plants has gained considerable attention in recent years mainly due to its function in plant growth and development and as a key signalling molecule in different intracellular processes in plants. The NO emission from plants is known since the 1970s, and now there is abundant information on the multiple effects of exogenously applied ...
Luis A, del Río, F Javier, Corpas, Juan B, Barroso   +2 more
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Nitric oxide synthase isozymes antibodies

The Histochemical Journal, 1995
Three isozymes of nitric oxide synthase (NOS) have been identified, cDNAs isolated and sequenced, and antibodies produced against each isozyme. Isozyme I (found primarily in central and peripheral neuronal cells), II (in cytokine-induced cells), and III (in endothelial cells) show less than 58% identity in the deduced amino acid sequences from humans ...
J S, Pollock, U, Förstermann, W R, Tracey, M, Nakane   +3 more
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Nitric oxide synthase and hypertension

Current Opinion in Nephrology and Hypertension, 2002
Nitric oxide, the metabolic product of L-arginine by the enzyme nitric oxide synthase, plays a pivotal role in the regulation of vascular homeostasis. Its complex interaction with the autocrine and paracrine systems, particularly angiotensin II, modulates vasoconstriction and vasodilatation as well as the architectural remodeling of the vascular bed ...
Baudouin, Leclercq, Edgar A, Jaimes, Leopoldo, Raij   +2 more
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