Results 251 to 260 of about 508,056 (310)

Regulation of nitric oxide synthase by nitric oxide.

Molecular Pharmacology, 1993
Nitric oxide (NO) is a recently discovered messenger for the activation of soluble guanylate cyclase in a wide variety of cell types. Although enzymes involved in NO synthesis have been discovered, the regulation of their action is not clear. The possibility of NO regulating the activity of a crude NO synthase (EC 1.14.23) preparation from bovine ...
A, Rengasamy, R A, Johns
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Nitric oxide synthase in invertebrates

The Histochemical Journal, 1995
The gas nitric oxide is now recognized as an important signalling molecule that is synthesized from L-arginine by the enzyme nitric oxide synthase. This enzyme can be localized by different methods, including immunocytochemistry and the histochemical reaction for NADPH diaphorase.
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Inhibition of Nitric Oxide Formation by Neuronal Nitric Oxide Synthase by Quinones:  Nitric Oxide Synthase as a Quinone Reductase

Chemical Research in Toxicology, 1998
Inhibitory action of a variety of quinoid compounds on neuronal nitric oxide synthase (nNOS) activity was examined with a 20000g rat cerebellar supernatant preparation and purified nNOS. The inhibition of citrulline formation from l-arginine by quinones, which exhibit one-electron reduction potentials (E17) ranging between -240 and -100 mV, increased ...
Y, Kumagai, H, Nakajima, K, Midorikawa, S, Homma-Takeda, N, Shimojo   +4 more
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Nitric oxide, nitric oxide synthase, and hypertensive vascular disease

Current Hypertension Reports, 1999
In normotension the endothelium produces mainly nitric oxide (NO) and prostacyclin, and the vasodilator and growth inhibitory influence predominates. Hypertension, however, is associated with a shift towards enhanced constriction and vascular hypertrophy.
R, Busse, I, Fleming
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Mitochondrial nitric oxide synthase

Mitochondrion, 2004
Nitric oxide (NO*) can bind to and inhibit the terminal enzyme of the mitochondrial respiratory chain, cytochrome c oxidase (complex IV). In vivo, NO* is made by the NO* synthase (NOS) family of enzymes, and considerable debate has recently arisen regarding a NOS inside mitochondria (termed 'mtNOS').
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Nitric Oxide Synthase Expression and Nitric Oxide Toxicity in Oligodendrocytes

Antioxidants & Redox Signaling, 2006
Oligodendrocytes (OLG) have more complex interactions with nitric oxide (NO) than initially suspected. Historically, OLG were seen only as targets of high NO levels released from other cells. Expression of nitric oxide synthase type II (NOS-2) in primary cultures of OLGs stimulated by cytokines led to controversy due to the presence of small numbers of
Anne I, Boullerne, Joyce A, Benjamins
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Nitric Oxide Synthase

, 2018
J. Kiel
semanticscholar   +2 more sources

Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes

Journal of Neuroscience Research, 1997
It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot and in situ hybridization analysis and a 131-kDa iNOS protein by Western blot analysis; protein was ...
J E, Merrill, S P, Murphy, B, Mitrovic, A, Mackenzie-Graham, J C, Dopp, M, Ding, J, Griscavage, L J, Ignarro, C J, Lowenstein   +8 more
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Nitric Oxide Synthase Assays

Current Protocols in Pharmacology, 1998
AbstractNitric oxide (NO) is a widespread messenger molecule that regulates cardiovascular tone, immune responses, and neuronal function. This unit provides a simple protocol for measuring NO production based on the stoichiometric formation of the byproduct L‐citrulline by nitric oxide synthase (NOS) when NO is produced.
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Nitric Oxide Synthase Inhibitors

2003
In 1990, several studies reported that an enhanced formation of endogenous nitric oxide (NO) contributes to the hypotension caused by endotoxin and tumor-necrosis factor-α (TNFα) (1-3). In addition, it became apparent that this overproduction of NO also plays an important role in the pathophysiology of the vascular hyporesponsiveness to vasoconstrictor
D K, Siriwardena, H, Tagori, C, Thiemermann   +2 more
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