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Bacterial Nitric Oxide Synthases
Annual Review of Biochemistry, 2010Nitric oxide synthases (NOSs) are multidomain metalloproteins first identified in mammals as being responsible for the synthesis of the wide-spread signaling and protective agent nitric oxide (NO). Over the past 10 years, prokaryotic proteins that are homologous to animal NOSs have been identified and characterized, both in terms of enzymology and ...
Brian R, Crane +2 more
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Biochemical Society Transactions, 1996
Nitric oxide (NO) is a biologically active product enzymatically formed from a terminal guanidino-nitrogen of L-arginine by members of the NO synthase (NOS) gene family. Members of NO synthases are classified into three isoforms NOS 1, 2, and 3. This original classification of NOS was based on the physical and biochemical characteristics of the ...
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Nitric oxide (NO) is a biologically active product enzymatically formed from a terminal guanidino-nitrogen of L-arginine by members of the NO synthase (NOS) gene family. Members of NO synthases are classified into three isoforms NOS 1, 2, and 3. This original classification of NOS was based on the physical and biochemical characteristics of the ...
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Mitochondrial nitric oxide synthase
Frontiers in Bioscience, 2007Nitric oxide (NO) regulates several cellular functions via reversible regulation of mitochondrial respiration. Nitric oxide also reacts with mitochondrial superoxide anion to produce the potent oxidative species peroxynitrite that irreversibly hinders mitochondrial activities. Recent findings demonstrating that mitochondria produce NO via mitochondrial
Pedram, Ghafourifar, Chandan K, Sen
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Mitochondrial nitric oxide synthase
Trends in Pharmacological Sciences, 2005Mitochondria produce nitric oxide (NO) through a Ca(2+)-sensitive mitochondrial NO synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via a reversible reaction with cytochrome c oxidase.
Pedram, Ghafourifar, Enrique, Cadenas
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Endothelial Nitric Oxide Synthase
2011Diabetic nephropathy remains a leading cause for end-stage renal disease indicating a failure of current therapeutic strategies. One factor that impairs our ability to make advances has been the inadequacy of most animal models in manifesting advanced diabetic renal disease.
Takahiko, Nakagawa, Richard J, Johnson
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Mitochondrial nitric oxide synthase
Mitochondrion, 2004Nitric oxide (NO*) can bind to and inhibit the terminal enzyme of the mitochondrial respiratory chain, cytochrome c oxidase (complex IV). In vivo, NO* is made by the NO* synthase (NOS) family of enzymes, and considerable debate has recently arisen regarding a NOS inside mitochondria (termed 'mtNOS').
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Nitric Oxide Synthase Inhibitors
2003In 1990, several studies reported that an enhanced formation of endogenous nitric oxide (NO) contributes to the hypotension caused by endotoxin and tumor-necrosis factor-α (TNFα) (1-3). In addition, it became apparent that this overproduction of NO also plays an important role in the pathophysiology of the vascular hyporesponsiveness to vasoconstrictor
D K, Siriwardena +2 more
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Current Protocols in Pharmacology, 1998
AbstractNitric oxide (NO) is a widespread messenger molecule that regulates cardiovascular tone, immune responses, and neuronal function. This unit provides a simple protocol for measuring NO production based on the stoichiometric formation of the byproduct L‐citrulline by nitric oxide synthase (NOS) when NO is produced.
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AbstractNitric oxide (NO) is a widespread messenger molecule that regulates cardiovascular tone, immune responses, and neuronal function. This unit provides a simple protocol for measuring NO production based on the stoichiometric formation of the byproduct L‐citrulline by nitric oxide synthase (NOS) when NO is produced.
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Nitric oxide, nitric oxide synthase, and hypertensive vascular disease
Current Hypertension Reports, 1999In normotension the endothelium produces mainly nitric oxide (NO) and prostacyclin, and the vasodilator and growth inhibitory influence predominates. Hypertension, however, is associated with a shift towards enhanced constriction and vascular hypertrophy.
R, Busse, I, Fleming
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Multimodality imaging of nitric oxide and nitric oxide synthases
Free Radical Biology and Medicine, 2009Nitric oxide (NO) and NO synthases (NOSs) are crucial factors in many pathophysiological processes such as inflammation, vascular/neurological function, and many types of cancer. Noninvasive imaging of NO or NOS can provide new insights in understanding these diseases and facilitate the development of novel therapeutic strategies.
Hao, Hong, Jiangtao, Sun, Weibo, Cai
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