Results 261 to 270 of about 344,134 (303)
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Catalysis by nitric oxide synthase
Current Opinion in Chemical Biology, 1998The enzyme nitric oxide synthase catalyzes the oxidation of the amino acid L-arginine to L-citrulline and nitric oxide in an NADPH-dependent reaction. Nitric oxide plays a critical role in signal transduction pathways in the cardiovascular and nervous systems and is a key component of the cytostatic/cytotoxic function of the immune system ...
M A, Marletta +2 more
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Nitric oxide and nitric oxide synthase activity in plants
Phytochemistry, 2004Research on NO in plants has gained considerable attention in recent years mainly due to its function in plant growth and development and as a key signalling molecule in different intracellular processes in plants. The NO emission from plants is known since the 1970s, and now there is abundant information on the multiple effects of exogenously applied ...
Luis A, del Río +2 more
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Nitric oxide synthase isozymes antibodies
The Histochemical Journal, 1995Three isozymes of nitric oxide synthase (NOS) have been identified, cDNAs isolated and sequenced, and antibodies produced against each isozyme. Isozyme I (found primarily in central and peripheral neuronal cells), II (in cytokine-induced cells), and III (in endothelial cells) show less than 58% identity in the deduced amino acid sequences from humans ...
J S, Pollock +3 more
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Nitric oxide synthase and hypertension
Current Opinion in Nephrology and Hypertension, 2002Nitric oxide, the metabolic product of L-arginine by the enzyme nitric oxide synthase, plays a pivotal role in the regulation of vascular homeostasis. Its complex interaction with the autocrine and paracrine systems, particularly angiotensin II, modulates vasoconstriction and vasodilatation as well as the architectural remodeling of the vascular bed ...
Baudouin, Leclercq +2 more
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Nitric oxide synthases and osteoarthritis
Current Rheumatology Reports, 2007The production of nitric oxide (NO) by chondrocytes is increased in human osteoarthritis. The excessive production of NO inhibits matrix synthesis and promotes its degradation. Furthermore, by reacting with oxidants such as superoxide anion, NO promotes cellular injury and renders the chondrocyte susceptible to cytokine-induced apoptosis.
Jose U, Scher +2 more
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Kidney Mitochondrial Nitric Oxide Synthase
Antioxidants & Redox Signaling, 2003Nitric oxide synthase activity was recognized in rat renal cortex mitochondria (mtNOS) with nitric oxide (NO) production rates of 0.14-0.78 nmol/min/mg of protein. Rat pretreatment with enalapril (30 mg/kg/day i.p., up to 15 days) increased NO production in kidney, liver, and heart mitochondria.
Alberto, Boveris +5 more
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Inducible Nitric Oxide Synthase Expression
Current Protocols in Toxicology, 2000AbstractThis unit contains three protocols that can be used to determine iNOS expression in mouse macrophage‐like cells, RAW 264.7, by measuring end product, protein, and mRNA. A bacterial product, lipopolysaccharide (LPS), stimulates iNOS expression in RAW 264.7 cells.
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Nitric oxide synthase in invertebrates
The Histochemical Journal, 1995The gas nitric oxide is now recognized as an important signalling molecule that is synthesized from L-arginine by the enzyme nitric oxide synthase. This enzyme can be localized by different methods, including immunocytochemistry and the histochemical reaction for NADPH diaphorase.
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Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers
2020Generation of nitric oxide (NO) by the nitric oxide synthase (NOS) enzymes plays multiple signalling roles in every organ system, with crucial roles in the cardiovascular system, mediated by endothelial nitric oxide synthase (eNOS, encoded by NOS3) and neuronal nitric oxide synthase (nNOS, encoded by NOS1) in regulation of blood pressure, flow, oxygen ...
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NITRIC OXIDE SYNTHASES: WHY SO COMPLEX?
Annual Review of Nutrition, 1994INTRODUCIlON . • . • • • • • • • . • • • • • • . . • • • • • • • • • • • . . • • • • • . • . • • . . . . . • • . . . . • . • 131 BIOLOGY OF NITRIC OXIDE AND NITRIC OXIDE SYNTHASES . • . . . . . . . • . . . . 132 CHARACTERIZATION OF NITRIC OXIDE SYNTHASES . . • . . . . . . . . . . . . . . • . . . 134 Biochemistry 134 Mechanism • • . . . . • • . • . • .
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