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Detection of nitric oxide and nitric oxide synthases in psoriasis
Archives of Dermatological Research, 1998Biopsies from psoriasis lesions and clinically uninvolved skin of eight patients and five normal subjects were studied by immunocytochemistry with computerized image analysis for the presence of endothelial, neuronal and inducible isoforms of nitric oxide synthase.
A D, Ormerod +6 more
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Nitric oxide and nitric oxide synthase activity in plants
Phytochemistry, 2004Research on NO in plants has gained considerable attention in recent years mainly due to its function in plant growth and development and as a key signalling molecule in different intracellular processes in plants. The NO emission from plants is known since the 1970s, and now there is abundant information on the multiple effects of exogenously applied ...
Luis A, del Río +2 more
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Catalysis by nitric oxide synthase
Current Opinion in Chemical Biology, 1998The enzyme nitric oxide synthase catalyzes the oxidation of the amino acid L-arginine to L-citrulline and nitric oxide in an NADPH-dependent reaction. Nitric oxide plays a critical role in signal transduction pathways in the cardiovascular and nervous systems and is a key component of the cytostatic/cytotoxic function of the immune system ...
M A, Marletta +2 more
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Biochemical Society Transactions, 1996
Nitric oxide (NO) is a biologically active product enzymatically formed from a terminal guanidino-nitrogen of L-arginine by members of the NO synthase (NOS) gene family. Members of NO synthases are classified into three isoforms NOS 1, 2, and 3. This original classification of NOS was based on the physical and biochemical characteristics of the ...
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Nitric oxide (NO) is a biologically active product enzymatically formed from a terminal guanidino-nitrogen of L-arginine by members of the NO synthase (NOS) gene family. Members of NO synthases are classified into three isoforms NOS 1, 2, and 3. This original classification of NOS was based on the physical and biochemical characteristics of the ...
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Nitric oxide synthases and osteoarthritis
Current Rheumatology Reports, 2007The production of nitric oxide (NO) by chondrocytes is increased in human osteoarthritis. The excessive production of NO inhibits matrix synthesis and promotes its degradation. Furthermore, by reacting with oxidants such as superoxide anion, NO promotes cellular injury and renders the chondrocyte susceptible to cytokine-induced apoptosis.
Jose U, Scher +2 more
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Nitric oxide synthase and hypertension
Current Opinion in Nephrology and Hypertension, 2002Nitric oxide, the metabolic product of L-arginine by the enzyme nitric oxide synthase, plays a pivotal role in the regulation of vascular homeostasis. Its complex interaction with the autocrine and paracrine systems, particularly angiotensin II, modulates vasoconstriction and vasodilatation as well as the architectural remodeling of the vascular bed ...
Baudouin, Leclercq +2 more
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Bacterial Nitric Oxide Synthases
Annual Review of Biochemistry, 2010Nitric oxide synthases (NOSs) are multidomain metalloproteins first identified in mammals as being responsible for the synthesis of the wide-spread signaling and protective agent nitric oxide (NO). Over the past 10 years, prokaryotic proteins that are homologous to animal NOSs have been identified and characterized, both in terms of enzymology and ...
Brian R, Crane +2 more
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Mitochondrial nitric oxide synthase
Frontiers in Bioscience, 2007Nitric oxide (NO) regulates several cellular functions via reversible regulation of mitochondrial respiration. Nitric oxide also reacts with mitochondrial superoxide anion to produce the potent oxidative species peroxynitrite that irreversibly hinders mitochondrial activities. Recent findings demonstrating that mitochondria produce NO via mitochondrial
Pedram, Ghafourifar, Chandan K, Sen
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Endothelial Nitric Oxide Synthase
2011Diabetic nephropathy remains a leading cause for end-stage renal disease indicating a failure of current therapeutic strategies. One factor that impairs our ability to make advances has been the inadequacy of most animal models in manifesting advanced diabetic renal disease.
Takahiko, Nakagawa, Richard J, Johnson
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Mitochondrial nitric oxide synthase
Trends in Pharmacological Sciences, 2005Mitochondria produce nitric oxide (NO) through a Ca(2+)-sensitive mitochondrial NO synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via a reversible reaction with cytochrome c oxidase.
Pedram, Ghafourifar, Enrique, Cadenas
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