Results 241 to 250 of about 344,134 (303)

Single‐nucleotide polymorphisms in coronary artery disease: Biological complexity, risk architecture, and implications for precision prevention

open access: yesPrecision Medical Sciences, EarlyView.
This graphical summary highlights the clinical application of single‐nucleotide polymorphisms‐based risk stratification in coronary artery disease. By integrating polygenic risk with clinical assessment, imaging, and preventive strategies, genetic information enables earlier risk identification, optimized screening, and personalized lifestyle and ...
Li Dai   +8 more
wiley   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang   +6 more
wiley   +1 more source

A Refined Carbohydrate-Rich Diet Reduces Vascular Reactivity Through Endothelial Oxidative Stress and Increased Nitric Oxide: The Involvement of Inducible Nitric Oxide Synthase. [PDF]

open access: yesNutrients
Neumann K   +10 more
europepmc   +1 more source

Microglia exhibit a dynamic response, modulating inducible nitric oxide synthase expression and the production of pro-inflammatory cytokines during experimental cerebral malaria. [PDF]

open access: yesFront Immunol
Freire-Antunes L   +6 more
europepmc   +1 more source

Nitric Oxide Synthase

2006
The discovery of the L–arginine:NO pathway has proven to be one of the most important and exciting scientific developments of the last decade. This pathway is involved in a myriad of physiologic roles that range from the control of vascular tone and blood pressure to the modulation of skeletal muscle function.
Nicolas J. Guzman, Bismark Amoah-Apraku
  +6 more sources

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