Results 91 to 100 of about 12,882,259 (299)

Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway

Frontiers in Pharmacology
Osteoarthritis (OA) is a common chronic disease characterized by progressive cartilage degeneration and secondary synovial inflammation. Bergamottin (Ber) is an important natural derivative of the furanocoumarin compound, extracted from natural foods ...
Guangjie Shen, Weihao Zhang, Qiming Tu, Juncheng Wang   +3 more
doaj   +1 more source

Nickel‐Catalyzed Three‐Component Difluoroalkylation‐Amination for the Direct Access to Anti‐Inflammatory β‐Difluoroalkyl Amines

Advanced Science, EarlyView.
A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu, Fangting Ma, Fan Ding, Luyan Wang, Yunxi Li, Yunzhi He, Xingang Zhang, Siyu He, Dandan Liu   +8 more
wiley   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Experimental endolymphatic hydrops under action of a type II nitric oxide synthase inhibitor: otoacoustic emissions evaluation and electrocochleography

Brazilian Journal of Otorhinolaryngology, 2006
In experimental endolymphatic hydrops distortion-products otoacoustic emission (dpoae) amplitudes decrease and there is elevation on electrocochleographic thresholds. Some authors found type ii nitric oxide synthase (nos ii) expression in hydropic cochleas and they suggest nitric oxide (no) may be involved in endolymphatic hydrops pathogenesis. The aim
Ikino, Claudio Marcio Yudi, Bittar, Roseli Saraiva Moreira, Sato, Karina Midori, Capella, Newton Macuco   +3 more
openaire   +2 more sources

The Serum Levels of Endothelium Nitric Oxide Synthase in Positive Cases for Helicobacter pylori Stool Antigen [PDF]

Background & Objectives: Endothelium nitric oxide synthase (eNOS) is a type of enzyme which produces an endogenous factor called nitric oxide (NO). NO plays important role in progress of euplastic diseases.
اتحاد, غلامحسین, امانی, مجتبی, پهلوان, یاسمین, افشار قهرمانی, فیروزه   +3 more
core  

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

The comparison of the effect of the aqueous extract of the Elaeagnus angustifolia with ibuprofen on the expression of the iNOS and COX2 genes in the cartilage tissue of rat rheumatoid arthritis model

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2018
BACKGROUND AND OBJECTIVE: Background and Purpose:Rheumatoid Arthritis (RA) is a chronic autoimmune disease, it is treated by nonstroidal anti-inflamatory drugs.
A Moradi, M Korani, GH Alishiri
doaj  

Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex

Frontiers in Neuroanatomy, 2015
In mammalian cerebrum there exist two distinct types of interneurons expressing nitric oxide synthase (NOS). Type I neurons are large in size and exhibit heavy nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemical reaction, while
Chao eLiu, Yan eYang, Xia eHu, Jian-Ming eLi, Xue-Mei eZhang, Yan eCai, Zhiyuan eLi, Xiao-Xin eYan   +7 more
doaj   +1 more source

Supplementation of 17β-Estradiol Normalizes Rapid Gastric Emptying by Restoring Impaired Nrf2 and nNOS Function in Obesity-Induced Diabetic Ovariectomized Mice

Antioxidants, 2020
Gastroparesis (Gp) is a multifactorial condition commonly observed in females and is characterized by delayed or rapid gastric emptying (GE). The role of ovarian hormones on GE in the pathogenesis of obesity induced type 2 diabetes mellitus (T2DM) is ...
Jeremy C. Sprouse, Chethan Sampath, Pandu R. Gangula   +2 more
doaj   +1 more source

INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION AND NUCLEAR FACTOR-κB ACTIVATION IN ALVEOLAR TYPE II CELLS IN LUNG INJURY

Experimental Lung Research, 2001
Alveolar type II cells (type II cells) play a crucial role in the progression and repair of lung inflammation and injury. We investigated whether inducible nitric oxide synthase (iNOS) was expressed and nuclear factor-kappaB (NF-kappaB) was activated in type II cells in lung injury.
H, Toga, T, Tobe, Y, Ueda, G H, Yang, K, Osanai, M, Ishigaki, H, Okazaki, S, Katsuda, K, Takahashi, N, Ohya   +9 more
openaire   +2 more sources