Results 91 to 100 of about 175,774 (310)

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Postsynaptic α1-Adrenergic vasoconstriction is impaired in young patients with vasovagal syncope and is corrected by nitric oxide synthase inhibition [PDF]

, 2016
BACKGROUND: Syncope is a sudden transient loss of consciousness and postural tone with spontaneous recovery; the most common form is vasovagal syncope (VVS).
Medow, MS, Merchant, S, Stewart, JM, Suggs, M, Sutton, R, Terilli, C, Visintainer, P   +6 more
core   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Bergamottin (Ber) ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway

Frontiers in Pharmacology
Osteoarthritis (OA) is a common chronic disease characterized by progressive cartilage degeneration and secondary synovial inflammation. Bergamottin (Ber) is an important natural derivative of the furanocoumarin compound, extracted from natural foods ...
Guangjie Shen, Weihao Zhang, Qiming Tu, Juncheng Wang   +3 more
doaj   +1 more source

Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex

Frontiers in Neuroanatomy, 2015
In mammalian cerebrum there exist two distinct types of interneurons expressing nitric oxide synthase (NOS). Type I neurons are large in size and exhibit heavy nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemical reaction, while
Chao eLiu, Yan eYang, Xia eHu, Jian-Ming eLi, Xue-Mei eZhang, Yan eCai, Zhiyuan eLi, Xiao-Xin eYan   +7 more
doaj   +1 more source

INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION AND NUCLEAR FACTOR-κB ACTIVATION IN ALVEOLAR TYPE II CELLS IN LUNG INJURY

Experimental Lung Research, 2001
Alveolar type II cells (type II cells) play a crucial role in the progression and repair of lung inflammation and injury. We investigated whether inducible nitric oxide synthase (iNOS) was expressed and nuclear factor-kappaB (NF-kappaB) was activated in type II cells in lung injury.
H, Toga, T, Tobe, Y, Ueda, G H, Yang, K, Osanai, M, Ishigaki, H, Okazaki, S, Katsuda, K, Takahashi, N, Ohya   +9 more
openaire   +2 more sources

Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling [PDF]

Cardiovascular Research, 2009
Valsartan, a selective angiotensin II type 1 receptor (AT1R) blocker, has beneficial effects in the cardiovascular system in part by its increase of nitric oxide (NO) bioavailability, yet the mechanisms are unclear. We investigated the molecular mechanisms underlying this effect in endothelial cells (ECs).NO production was examined by Griess reagent ...
Kuo-Hui, Su, Jin-Yi, Tsai, Yu Ru, Kou, An-Na, Chiang, Sheng-Huang, Hsiao, Yuh-Lin, Wu, Hsin-Han, Hou, Ching-Chian, Pan, Song-Kun, Shyue, Tzong-Shyuan, Lee   +9 more
openaire   +2 more sources

Connexin 43 plays a role in pulmonary vascular reactivity in mice [PDF]

, 2018
Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1).
Andrew Shaw, Bradley Foote, Ergul, Jane Nally, Johnstone, MacLean, Myo Htet, Patricia Martin, Van Kempen, Yang, Yang, Yvonne Dempsie   +11 more
core   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Thymoquinone (TQ) inhibits the replication of intracellular Mycobacterium tuberculosis in macrophages and modulates nitric oxide production

BMC Complementary and Alternative Medicine, 2017
Background Human tuberculosis, which is caused by the pathogen Mycobacterium tuberculosis, remains a major public health concern. Increasing drug resistance poses a threat of disease resurgence and continues to cause considerable mortality worldwide ...
Hafij Al Mahmud, Hoonhee Seo, Sukyung Kim, Md Imtiazul Islam, Kung-Woo Nam, Hyun-Deuk Cho, Ho-Yeon Song   +6 more
doaj   +1 more source