Results 221 to 230 of about 1,819 (263)

Type II nitric oxide synthase activity is cardio-protective in experimental sepsis

European Journal of Pharmacology, 2003
Overproduction of nitric oxide (NO) via the induction of NO synthase (NOS) II is implicated in the pathogenesis of the refractory hypotension that characterizes septic shock. However, clinical trials of nonselective NOS inhibitors have failed to afford a mortality benefit in patients with sepsis, and in those with depressed left ventricular function ...
Suzanna, Price, Jane A, Mitchell, Peter B, Anning, Timothy W, Evans   +3 more
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Leptin induces nitric oxide synthase type II in C6 glioma cells

Neuroscience Letters, 2006
Astrocytes in the CNS produce inflammatory mediators in response to several stimuli and cytokines. Here we investigated the in vitro effect of leptin on inducible nitric oxide synthase (iNOS) expression in a glioma cell line (C6). After hormone stimulation, culture media were analysed for accumulated stable oxidation products of NO (NO2(-) and NO3 ...
Giuseppina Mattace Raso, Emanuela Esposito, Anna Iacono, Maria Pacilio, Anna Coppola, Giuseppe Bianco, Sabrina Diano, Raffaele Di Carlo, Rosaria Meli   +8 more
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Nitric Oxide Synthase Type II mRNA Stability Is Translation‐ and Transcription‐Dependent

Journal of Neurochemistry, 1996
Abstract: Nitric oxide synthase (NOS) type II is induced in many cell types in response to cytokines or endotoxin. The duration of type II NOS mRNA expression in astroglial cells and macrophages in vitro is brief, even in the continuous presence of inducers, and their removal dramatically accelerates mRNA decay.
S K, Park, S, Murphy
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Direct Effect of Temperature on the Catalytic Activity of Nitric Oxide Synthases Types I, II, and III

Nitric Oxide, 1999
The effect of temperature (between 5.0 and 45.0 degrees C) on the catalytic activity of nitric oxide synthases types I, II, and III (NOS-I, NOS-II, and NOS-III, respectively) has been investigated, at pH 7.5. The value of V(max) for NOS-I activity increases from 1.8 x 10(1) pmol min(-1) mg(-1), at 5.0 degrees C, to 1.8 x 10(2) pmol min(-1) mg(-1), at ...
VENTURINI G, COLASANTI, Marco, FIORAVANTI E, BIANCHINI A, ASCENZI P.   +4 more
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Production of Nitric Oxide by Rat Type II Pneumocytes: Increased Expression of Inducible Nitric Oxide Synthase Following Inhalation of a Pulmonary Irritant

American Journal of Respiratory Cell and Molecular Biology, 1994
Abstract Nitric oxide is a highly reactive molecule that has been implicated in host defense and tissue injury. In the present studies, we determined whether rat type II alveolar epithelial cells have the capacity to produce this mediator.
C J, Punjabi, J D, Laskin, K J, Pendino, N L, Goller, S K, Durham, D L, Laskin   +5 more
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Cytokine‐induced expression of type II nitric oxide synthase in astrocytes is downregulated by ATP and glutamate

Glia, 1995
AbstractCombinations of cytokines and/or phorbol ester induce expression of Type II nitric oxide synthase (NOS) mRNA in astrocyte cultures via protein kinase mediated pathways (Simmons and Murphy: GLIA 11:227, 1994; Feinstein et al.: J Neurochem 62:811,1994).
S, Murphy, H L, Lin, S K, Park
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Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats

Life Sciences, 2003
The goals of this study were to determine the effects of type II diabetes mellitus on nitric oxide synthase-dependent responses of cerebral arterioles and on endothelial nitric oxide synthase (eNOS) protein in cerebral arterioles. We examined dilatation of cerebral (pial) arterioles in 13-15 week old male lean and diabetic obese Zucker rats in response
RoseAnn M, Schwaninger, Hong, Sun, William G, Mayhan   +2 more
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Macrophage triggering with cecropin A and melittin-derived peptides induces type II nitric oxide synthase expression

The Journal of Immunology, 1997
Abstract Triggering of RAW 264.7 cells with a cecropin A-melittin hybrid peptide (CA(1-8)M(1-18)) promoted a rapid rise in the intracellular calcium concentration that was followed, after a lag period of 6 h, by nitric oxide synthesis through the expression of the cytokine-inducible form of nitric oxide synthase (type II NOS or iNOS).
M, Velasco, M J, Díaz-Guerra, P, Díaz-Achirica, D, Andreu, L, Rivas, L, Boscá   +5 more
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Correlation between type II nitric oxide synthase and p53 expression in oral squamous cell carcinoma

British Journal of Oral and Maxillofacial Surgery, 2000
Prolonged nitric oxide (NO) production by the enzyme type II nitric oxide synthase (NOS2) has been implicated in angiogenesis and metastasis of human cancers. In animal models, wild-type p53 (but not mutant) protein results in down-regulation of NOS2 expression, which reduces both tumour growth and dissemination.
P A, Brennan, M, Palacios-Callender, T, Umar, D, Hughes, A V, Spedding, G A, Zaki, J D, Langdon   +6 more
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Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain

Neuroscience Letters, 2002
Nitric oxide synthase inhibitors have been regarded as potentially beneficial for psychiatric disorders such as depression and schizophrenia, though little is known about how nitric oxide synthases are affected by psychotropic drugs in the brain. Using reverse transcription-polymerase chain reaction analysis, we investigated the effects of short- and ...
Eiji, Suzuki, Toshio, Nakaki, Futoshi, Shintani, Shigenobu, Kanba, Hitoshi, Miyaoka   +4 more
openaire   +2 more sources