Results 241 to 250 of about 437,208 (310)

Modulation of heme peroxo nucleophilicities with axial ligands reveal key insights into the mechanistic landscape of nitric oxide synthase. [PDF]

Chem Sci
Rajapakse S, Lee Y, Jayawardana SB, Helms J, Mondal P, Singh A, Pierce BS, Shafaat HS, Wijeratne GB.   +8 more
europepmc   +1 more source

Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato‐venereologists

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. [PDF]

Eur Heart J
Abdellatif M, Vasques-Nóvoa F, Trummer-Herbst V, Durand S, Koser F, Islam M, Nah J, Sung EA, Feng R, Aprahamian F, Prokesch A, Zardoya-Laguardia P, Sadoshima J, Diwan A, Linke WA, Ferreira JP, Kroemer G, Sedej S.   +17 more
europepmc   +1 more source

New insights in cellular senescence: The pituitary model

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Senescence is a pivotal process in pituitary tumorigenesis. Recent advances have elucidated the complex mechanisms by which key factors, including IL‐6, establish and maintain senescence in these tumors. Given the critical role of senescence and the development of novel techniques to detect senescent cells, the identification of biomarkers and the ...
Florencia Herbstein, Josefina Rosmino, Mirtha Adriana Guitelman, Joaquina Cagliero, David Gonilski‐Pacin, Nicolas Ciancio Del Giudice, Manuel Fiz, Mariana Fuertes, Eduardo Arzt   +8 more
wiley   +1 more source

Depletion of Mitochondrial Cyclophilin D in Endothelial and Smooth Muscle Cells Attenuates Vascular Dysfunction and Hypertension. [PDF]

Function (Oxf)
Dikalova A, Ao M, Lantier L, Gutor S, Dikalov S.   +4 more
europepmc   +1 more source

Xanthine Derivative KMUP‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis

Journal of Periodontal Research, EarlyView.
This study reveals that our self‐developed xanthine derivative, KMUP‐3, suppresses osteoclastogenesis, inflammation, and pyroptosis by inhibiting the NLRP3 inflammasome. It also alleviates periodontal bone loss in periodontitis rats, highlighting its potential as a novel therapeutic option for periodontitis.
Shang‐En Huang, Kai‐Fang Hu, Meng‐Xuan Lin, Ching‐Jiunn Tseng, Bin‐Nan Wu, Zen‐Kong Dai, Jong‐Hau Hsu, Jwu‐Lai Yeh   +7 more
wiley   +1 more source

Correction: Lymphatic transport in anti-tumor immunity and metastasis. [PDF]

J Exp Med
Sun M, Angelillo J, Hugues S.
europepmc   +1 more source

In Vivo Nitrosative Stress‐Induced Expression of a Photolyase Promotes Vibrio cholerae Environmental Blue Light Resistance

Molecular Microbiology, Volume 123, Issue 4, Page 295-304, April 2025.
This study demonstrates how Vibrio cholerae activates the cry1 gene in response to host‐derived reactive nitrogen species (RNS) during infection via the ChrR‐RpoE pathway. This activation enhances bacterial resilience to environmental stressors, particularly blue light, by driving Cry1‐mediated DNA repair mechanisms.
Arkaprabha Banerjee, Hyuntae Byun, Andrew J. Hrycko, Qinqin Pu, Mary R. Brockett, Nathaniel C. Esteves, Jennifer R. Miller, Qiushi Li, Amy T. Ma, Jun Zhu   +9 more
wiley   +1 more source

Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies. [PDF]

Commun Biol
Mohanty I, Fazelinia H, Raimo S, Ding H, Spruce L, Symeonidou M, Tenopoulou M, Ichinose F, Yamashita H, Shimokawa H, Masato T, Doulias PT, Ischiropoulos H.   +12 more
europepmc   +1 more source

Enteric neuropathy and the vagus nerve: Therapeutic implications

Neurogastroenterology &Motility, EarlyView.
Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley   +1 more source