Results 251 to 260 of about 437,208 (310)

Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas. [PDF]

Antioxidants (Basel)
Martelli A, Abate F, Roggia M, Benedetti G, Caradonna E, Calderone V, Tenore GC, Cosconati S, Novellino E, Stornaiuolo M.   +9 more
europepmc   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, EarlyView.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source

Role of Melatonin in Regulating Rat Skeletal Muscle Tissue Inflammation and Damage Following Carbon Tetrachloride Intoxication. [PDF]

Int J Mol Sci
Antić VM, Antic M, Stojiljkovic N, Stanković N, Pavlović M, Sokolović D.   +5 more
europepmc   +1 more source

Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction

Neurogastroenterology &Motility, EarlyView.
Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley   +1 more source

Elucidating the preventive and therapeutic effects of cardiac telocytes paracrine microRNAs on ischemic heart disease. [PDF]

Front Cardiovasc Med
Jiang H, Tang Y, Liu A, Ren C, Lin W, Liu K, Zhao X, Li Y.   +7 more
europepmc   +1 more source

Chemotherapy‐Induced Neuropathy Affecting the Gastrointestinal Tract

Neurogastroenterology &Motility, EarlyView.
Chemotherapy (with/without immunotherapy/radiotherapy) may induce neurotoxic effects on the gastrointestinal innervation. Chemotherapy‐induced enteric neuropathy (CIEN) and, probably, neurotoxicity affecting the extrinsic innervation of the gut and the brain underlie the frequent and impactful gut dysfunctions and brain–gut axis (BGA) disorders ...
Gema Vera, Kulmira Nurgali, Raquel Abalo
wiley   +1 more source

Vasoplegic syndrome in cardiac surgery: bridging therapeutic gaps with best practices and future research. [PDF]

Interdiscip Cardiovasc Thorac Surg
Unic-Stojanovic D, Koster A, Erdoes G, Milojevic M.   +3 more
europepmc   +1 more source

Gastrointestinal Dysfunction and Low‐Grade Inflammation Associate With Enteric Neuronal Amyloid‐β in a Model for Amyloid Pathology

Neurogastroenterology &Motility, Volume 37, Issue 5, May 2025.
Amyloid‐β accumulation in enteric neurons is associated with low‐grade intestinal inflammation, fibrosis, and altered motility in a mouse model for amyloid pathology, suggesting that peripheral pathology may cause gastrointestinal dysfunction in Alzheimer's disease patients. ABSTRACT Background Patients suffering from Alzheimer's disease, a progressive
Kinga Réka Tasnády, Reindert Jehoul, Manuel Gutiérrez de Ravé, Marion J. Gijbels, Bert Brône, Ilse Dewachter, Veerle Melotte, Werend Boesmans   +7 more
wiley   +1 more source

Endoplasmic reticulum stress and expression of nitric oxide synthases in heart failure with preserved and with reduced ejection fraction - pilot study. [PDF]

Cardiol J
Momot K, Wojciechowska M, Krauz K, Czarzasta K, Puchalska L, Zarębiński M, Cudnoch-Jędrzejewska A.   +6 more
europepmc   +1 more source

Cold seeps are potential hotspots of deep-sea nitrogen loss driven by microorganisms across 21 phyla. [PDF]

Nat Commun
Jiang Q, Cao L, Han Y, Li S, Zhao R, Zhang X, Ruff SE, Zhao Z, Peng J, Liao J, Zhu B, Wang M, Lin X, Dong X.   +13 more
europepmc   +1 more source