Results 61 to 70 of about 178,919 (340)

Literature-based discovery of diabetes- and ROS-related targets [PDF]

, 2010
Background Reactive oxygen species (ROS) are known mediators of cellular damage in multiple diseases including diabetic complications. Despite its importance, no comprehensive database is currently available for the genes associated with ROS.
A Erol, A Fontayne, A Iaccio, Adam D Schuyler, AG Reaume, AM Vincent, AM Vincent, AM Vincent, AM Vincent, American-Diabetes-Association, BJ Turner, C Figueroa-Romero, C Plake, D Rebholz-Schuhmann, David J States, E Schwedhelm, EH Sarsour, EL Feldman, EM Olofsson, Eva L Feldman, F Folli, FA Hakim, FR DeRubertis, H Ilieva, H V Jagadish, HB Lee, I Vastrik, J Hur, JL Edwards, JM Jimenez-Andrade, JS Pan, Junguk Hur, JW Russell, KA Sullivan, Kelli A Sullivan, KK Ohlemiller, L Hirschman, M Ashburner, M Brownlee, M Fukuda, M Fukuda, M Kanehisa, M Kawase, Manjusha Pande, N Kameyama, PJ Shaw, RA Fisher, S Cetinkalp, S Ghosh, T Matsunami, VI Perez, Y Aliciguzel, Y Benjamini, Yu Hong, Z Bagi   +54 more
core   +5 more sources

Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via AT1R Nox/ROS/PP2A Pathway

Frontiers in Physiology, 2020
Increasing evidences suggest that angiotensin (Ang) II participates in the pathogenesis of endothelial dysfunction (ED) through multiple signaling pathways, including angiotensin type 1 receptor (AT1R) mediated NADPH oxidase (Nox)/reactive oxygen species
Jing Ding, Jing Ding, Min Yu, Min Yu, Juncai Jiang, Juncai Jiang, Yanbei Luo, Yanbei Luo, Qian Zhang, Qian Zhang, Shengnan Wang, Fei Yang, Alei Wang, Alei Wang, Lingxiao Wang, Lingxiao Wang, Mei Zhuang, Shan Wu, Qifang Zhang, Yong Xia, Deqin Lu, Deqin Lu   +21 more
doaj   +1 more source

Synergistic effect of angiotensin II type 1 receptor and endothelial nitric oxide synthase gene polymorphisms on arterial stiffness [PDF]

Journal of Human Hypertension, 2007
Angiotensin II and nitric oxide belong to important factors in the functional and structural changes of vessel wall, leading to its increased stiffness. We investigated, whether common mutations of angiotensin II type 1 receptor (AGTR(1)) and endothelial nitric oxide synthase (eNOS) are associated with increased arterial stiffness. Two polymorphisms, A(
O, Mayer, J, Filipovský, M, Pesta, R, Cífková, M, Dolejsová, J, Simon   +5 more
openaire   +2 more sources

Microvascular alterations in hypertension and vascular aging [PDF]

, 2017
Hypertension and aging are characterized by vascular remodelling and stiffness as well as endothelial dysfunction. Endothelial function declines with age, since aging is associated with senescence of the endothelium due to increased rate of apoptosis and
Battistoni, Allegra, Calvez, Valentin, Cesario, Vincenzo, Filippini, Antonio, Montefusco, G, Savoia, Carmine   +5 more
core   +1 more source

Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling [PDF]

, 2014
The renin angiotensin system (RAS) is integral to cardiovascular physiology, however, dysregulation of this system largely contributes to the pathophysiology of cardiovascular disease (CVD).
Akishita, Barroso, Booz, Bosnyak, Bosnyak, Brosnihan, Bruneval, Bryan, Calo, Campbell, Caroline Fattah, Castro, Chappell, Chappell, Chen, Christopher M. Loughrey, Clare A. McKinney, Clarke, Costa, Crackower, Cushman, De Mello, Dias-Peixoto, Domeier, Dong, Donoghue, Donoghue, Drummer, Faria-Silva, Ferreira, Ferreira, Ferreira, Ferreira, Flores-Munoz, Flores-Munoz, Fomovsky, Fraga-Silva, Fraga-Silva, Freeman, Galis, Gava, Gembardt, Gomes, Graeme Milligan, Grobe, Gusev, Hanke, Hannan, Harmer, Heitsch, Horiguchi, Horiuchi, Hunyady, Inaba, Iwata, Jackman, Jaiswal, Jarajapu, Kaminska, Kassiri, Katada, Kokkonen, Kramkowski, Langeveld, Lautner, Liao, Libby, Liu, Loot, Lovren, Masson, McCollum, Mehta, Mercure, Miura, Mogielnicki, Nakajima, Newby, Ng, Nouet, Ocaranza, Ocaranza, Ocaranza, Patel, Patel, Qi, Ray, Rice, Rodgers, Rodrigues-Machado, Ross, Rowe, Sampaio, Sampaio, Santos, Santos, Schultz Jel, Selvetella, Shah, Sheng-Long, Singh, Sluimer, Stegbauer, Strawn, Stuart A. Nicklin, Tallant, Tesanovic, Tipnis, Turner, Uekama, Varagic, Vickers, Vilas-Boas, Walters, Wang, Weber, West, Wiemer, Yamada, Yang, Zeng, Zhang, Zhao, Zhong   +123 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Angiotensin II Induces Oxidative Stress and Endothelial Dysfunction in Mouse Ophthalmic Arteries via Involvement of AT1 Receptors and NOX2

Antioxidants, 2021
Angiotensin II (Ang II) has been implicated in the pathophysiology of various age-dependent ocular diseases. The purpose of this study was to test the hypothesis that Ang II induces endothelial dysfunction in mouse ophthalmic arteries and to identify the
Michael Birk, Ewa Baum, Jenia Kouchek Zadeh, Caroline Manicam, Norbert Pfeiffer, Andreas Patzak, Johanna Helmstädter, Sebastian Steven, Marin Kuntic, Andreas Daiber, Adrian Gericke   +10 more
doaj   +1 more source

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]

, 2011
Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin, Kunuthur, S. P., Milliken, P. H., Suckling, C. J., Wadsworth, R. M.   +4 more
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Chloroquine potentially modulated innate immune response to Vibrio parahaemolyticus in RAW 264.7 macrophages

Food and Agricultural Immunology, 2021
Vibrio parahaemolyticus, as a vibriosis, causes huge losses to the aquaculture industry, food poisoning in humans and activates macrophages to induce pro-inflammatory cytokines.
Xifeng Qiao, Pingchao Li, Haoran Lin, Yong Zhang, Ying Zhu, Zhiyun Du, Danqi Lu   +6 more
doaj   +1 more source