Results 181 to 190 of about 69,950 (233)

Insulin facilitates entry of calcium ions into human and murine erythrocytes via Piezo1: a newly identified mechanism with implications for type 2 diabetes

The FEBS Journal, EarlyView.
Despite being enucleated, mammalian red blood cells (RBCs) possess complex signaling mechanisms. Here, we show that insulin signals through the mechanosensitive channel Piezo1 to promote influx of calcium ions. This newly identified pathway is disrupted in a murine model of type 2 diabetes and may contribute to driving circulatory deficits in prevalent
Lennart Kuck, Tia A. Griffith, Antony P. McNamee, Jason N. Peart, John H. Wilson, Ajay Sharma, Lavanya A. Sharma, Kai Robertson, Eugene F. Du Toit, Michael J. Simmonds   +9 more
wiley   +1 more source

Relationship Between Periodontitis and Nitric Oxide in Patients Undergoing Maintenance Hemodialysis

Hemodialysis International, EarlyView.
ABSTRACT Background The inflammatory processes associated with periodontitis have been implicated in the development and progression of systemic diseases, including chronic kidney disease (CKD). Notably, individuals with CKD frequently exhibit shared risk factors with those affected by periodontitis, such as hypertension, smoking, and diabetes mellitus.
Gabriela Keiko Izumi, Caroline Vidal Paseto, Rafael Fiorese Costa, Gabrielle Delfrate, Aline Borsato Hauser, Daniel Fernandes, Maria Ângela Naval Machado, Reila Tainá Mendes   +7 more
wiley   +1 more source

Pathogenesis of Melasma Explained

International Journal of Dermatology, EarlyView.
Pathophysiology of melasma. ABSTRACT This review provides an in‐depth analysis of the pathophysiology of melasma and highlights recent studies that elucidate its underlying mechanisms. Given the prevalence of melasma, a thorough understanding of its pathogenesis is critical for the development of effective treatment strategies.
Lara Ali, Firas Al Niaimi
wiley   +1 more source

The loss of the urea cycle and ornithine metabolism in different insect orders: An omics approach

Insect Molecular Biology, EarlyView.
Among urea cycle enzymes, only the nitric oxide synthase gene is universally present across insect genomes. All Hemiptera species lack the enzymes needed to convert citrulline to arginine, and some also lack the pathway from arginine to ornithine. Putrescine and spermidine synthesis is conserved in all insects, but aphids lack the capability to produce
Jessica Cristina Silva Martins, Héctor Antônio Assunção Romão, Carolina Kurotusch Canettieri, Amanda Caetano Cercilian, Patrícia Rasteiro Ordiale Oliveira, Clelia Ferreira, Walter R. Terra, Renata de Oliveira Dias   +7 more
wiley   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, EarlyView.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Canagliflozin protects cardiovascular function in type 2 diabetic coronary artery disease by regulating natriuretic peptide B

Journal of Diabetes Investigation, EarlyView.
Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang, Lichenlu Huang, Yongqin Zheng, Ji Yang, Xiaopei Wu, Jundong He   +5 more
wiley   +1 more source

Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato‐venereologists

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

Xanthine Derivative KMUP‐3 Alleviates Periodontal Bone Resorption by Inhibiting Osteoclastogenesis and Macrophage Pyroptosis

Journal of Periodontal Research, EarlyView.
This study reveals that our self‐developed xanthine derivative, KMUP‐3, suppresses osteoclastogenesis, inflammation, and pyroptosis by inhibiting the NLRP3 inflammasome. It also alleviates periodontal bone loss in periodontitis rats, highlighting its potential as a novel therapeutic option for periodontitis.
Shang‐En Huang, Kai‐Fang Hu, Meng‐Xuan Lin, Ching‐Jiunn Tseng, Bin‐Nan Wu, Zen‐Kong Dai, Jong‐Hau Hsu, Jwu‐Lai Yeh   +7 more
wiley   +1 more source

Enteric neuropathy and the vagus nerve: Therapeutic implications

Neurogastroenterology &Motility, EarlyView.
Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, EarlyView.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source