Results 41 to 50 of about 11,182 (261)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Nitrification and denitrification processes in a zero-water exchange aquaculture system: characteristics of the microbial community and potential rates

Frontiers in Marine Science, 2023
​The zero-water exchange aquaculture has been identified as a promising method of farming to decrease the environment pressure of aquaculture and to increase profits.
Shuhui Niu, Shuhui Niu, Shuhui Niu, Kai Zhang, Kai Zhang, Zhifei Li, Zhifei Li, Guangjun Wang, Guangjun Wang, Hongyan Li, Hongyan Li, Yun Xia, Yun Xia, Jingjing Tian, Jingjing Tian, Ermeng Yu, Ermeng Yu, Wangbao Gong, Wangbao Gong, Jun Xie, Jun Xie   +20 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Contribution of Root Turnover on Biological Nitrification Inhibition and Its Impact on the Ammonia-Oxidizing Archaea under Brachiaria Cultivations

Agronomy, 2020
Aims: Biological nitrification inhibition (BNI) has been reported as an emerging technology to control soil nitrifier activity for effective N-utilization in cropping systems.
Satoshi Nakamura, Papa Sarr Saliou, Minako Takahashi, Yasuo Ando, Guntur Venkata Subbarao   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effectiveness of Nitrification Inhibition on Various Species of Brachiaria Grass Rhizosphere

E3S Web of Conferences, 2018
Nitrification has the potential to decrease the efficiency of nitrogen utilization by plants. The use of nitrifying inhibitory chemicals proved to be effective in controlling nitrification, but also affects beneficial soil microbes.
Purwanto, Supriyadi, Hindrayani Aniek
doaj   +1 more source

Critical analysis of decay rate measurement methodology [PDF]

E3S Web of Conferences, 2019
In modeling studies, estimation of microorganisms kinetic parameters set is a key element for proper model operation and predictability. Nitrification process is very often, a crucial element of the wastewater treatment systems as bacteria responsible ...
Kokurewicz Łukasz, Muszyński-Huhajło Mateusz, Miodoński Stanisław, Leoniak Maciej   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Heterotrophic nitrification of organic nitrogen is stimulated by agricultural plants

Communications Earth & Environment
The association between soil heterotrophic nitrification and plant nitrogen (N) uptake remains poorly understood. Here, we used 15N isotope tracing and numerical analysis to quantify the rate of ammonification (organic N to ammonium), heterotrophic ...
Shending Chen, Zucong Cai, Mengqiu He, Ahmed S. Elrys, Lei Meng, Jun Zhao, Xinqi Huang, Jinbo Zhang, Christoph Müller   +8 more
doaj   +1 more source

Effects of combined application of nitrogen fertilizer and biochar on the nitrification and ammonia oxidizers in an intensive vegetable soil

AMB Express, 2017
Soil amended with single biochar or nitrogen (N) fertilizer has frequently been reported to alter soil nitrification process due to its impact on soil properties.
Qing-Fang Bi, Qiu-Hui Chen, Xiao-Ru Yang, Hu Li, Bang-Xiao Zheng, Wei-Wei Zhou, Xiao-Xia Liu, Pei-Bin Dai, Ke-Jie Li, Xian-Yong Lin   +9 more
doaj   +1 more source