Syntheses of Isoxazoline-Based Amino Acids by Cycloaddition of Nitrile Oxides and Their Conversion into Highly Functionalized Bioactive Amino Acid Derivatives [PDF]
, 2012 The present account illustrates the syntheses of isoxazoline-based amino acids by the cycloaddition of 1,3-dipolar nitrile oxides to the C–C double bond of unsaturated amino acid derivatives, with focus on the regio- and stereoselectivities of the ...
F. Fülöp, Lóránd Kiss, Melinda Nonn
semanticscholar +4 more sources
1,3-Dipolar cycloadditions of acridine with nitrile oxides [PDF]
ARKIVOC, 2002 Siteand regio-isomeric mono-cycloadducts 9 are formed in the reactions of mesito1b and dichloromesitonitrile oxide 1c with acridine 6 in a 1:2 ratio, while the reaction of 1b and 6 in a 10:1 ratio afforded, besides the mono-cycloadduct 9b and traces of the corresponding oxime 10b, the bis-cycloadduct 12 with the opposite regiochemistry to that of the ...
Antonino Corsaro +5 more
doaj +6 more sources
Metal-catalyzed 1,3-dipolar cycloaddition reactions of nitrile oxides. [PDF]
Organic and biomolecular chemistry, 2018 In the present review advances in the metal-catalyzed 1,3-dipolar cycloaddition reactions of nitrile oxides, mainly in the last decade, will be presented and discussed. An overview on the structure, preparation, dimerization and related reactions as well
Silvia Roscales, J. Plumet
semanticscholar +4 more sources
eXPRESS Polymer Letters, 2009 The aim of this work was to study the activity of several nanosized zinc oxides in the crosslinking of carboxylated nitrile elastomer (XNBR). In this article, we discuss the effect of zinc oxide nanoparticles with respect to their specific surface area ...
M. Przybyszewska, Marian Zaborski
doaj +2 more sources
Isoxazolodihydropyridinones: 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines. [PDF]
ACS Comb Sci, 2012 Practical and efficient methods have been developed for the diversity-oriented synthesis of isoxazolodihydropyridinones via the 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines.
Coffman KC +3 more
europepmc +2 more sources
Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides [PDF]
Beilstein Journal of Organic Chemistry, 2016 Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical methods. (E)-β-(4-Nitroimidazol-5-yl), (5-nitroimidazol-4-yl) and isoxazol-5-yl enamines smoothly react regioselectively at room temperature in dioxane ...
Ilya V. Efimov +10 more
doaj +2 more sources
Solution-phase synthesis of a diverse library of benzisoxazoles utilizing the [3 + 2] cycloaddition of in situ-generated nitrile oxides and arynes. [PDF]
ACS Comb Sci, 2013 A library of benzisoxazoles has been synthesized by the [3 + 2] cycloaddition of nitrile oxides with arynes and further diversified by acylation/sulfonylation and palladium-catalyzed coupling processes. The eight key intermediate benzisoxazoles have been
Dubrovskiy AV +6 more
europepmc +2 more sources
Pharmacochemical Studies of Synthesized Coumarin–Isoxazole–Pyridine Hybrids [PDF]
MoleculesSeveral new coumarin–isoxazole–pyridine hybrids were synthesized through a 1,3-dipolar cycloaddition reaction of nitrile oxides, prepared in situ from pyridine aldehyde oximes, with propargyloxy- or propargylaminocoumarins in moderate-to-good yields ...
Matina D. Douka +5 more
doaj +2 more sources
Studies of the Synthesis of Fused Isoxazoline/Isoquinolinones and Evaluation of the Antifungal Activity of Isoxazole-like Benzamide and Isoquinolinone Hybrids [PDF]
MoleculesIsoxazole derivatives (isoxazoles, isoxazolines, and isoxazolidines) are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis +3 more
doaj +2 more sources
Unexpected catalytic reactions of silyl-protected enol diazoacetates with nitrile oxides that form 5-arylaminofuran-2(3H)-one-4-carboxylates. [PDF]
Org Lett, 2012 Silyl-protected enol diazoacetates undergo dirhodium(II)-catalyzed reactions with nitrile oxides to form acid-labile ketenimines via dipolar cycloaddition of nitrile oxides to a donor/acceptor cyclopropene and Lossen rearrangement of the dipolar adduct ...
Xu X, Shabashov D, Zavalij PY, Doyle MP.
europepmc +2 more sources