The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Structure and mechanism of copper–carbonic anhydrase II: a nitrite reductase
IUCrJ, 2020 Nitric oxide (NO) promotes vasodilation through the activation of guanylate cyclase, resulting in the relaxation of the smooth muscle vasculature and a subsequent decrease in blood pressure.
Jacob T. Andring +2 more
doaj +1 more source
Inheritance of nitrite reductase and regulation of nitrate reductase, nitrite reductase, and glutamine synthetase isozymes. [PDF]
Plant Physiology, 1984 Banding patterns of nitrate reductase (NR), nitrite reductase (NiR), and glutamine synthetase (GS) from leaves of diploid barley (Hordeum vulgare), tetraploid wheat (Triticum durum), hexaploid wheat (Triticum aestivum), and tetraploid wild oats (Avena barbata) were compared following starch gel electrophoresis.
S, Heath-Pagliuso +2 more
openaire +2 more sources
Endothelial alpha globin is a nitrite reductase [PDF]
Nature Communications, 2021 Abstract Resistance artery vasodilation in response to hypoxia is essential for matching tissue oxygen and demand. In hypoxia, erythrocytic hemoglobin tetramers produce nitric oxide through nitrite reduction. We hypothesized that the alpha subunit of hemoglobin expressed in endothelium also facilitates nitrite reduction proximal to ...
T. C. Stevenson Keller +28 more
openaire +3 more sources
Redox Biology, 2018 Nitric oxide radical (NO) is a signaling molecule involved in several physiological and pathological processes and a new nitrate-nitrite-NO pathway has emerged as a physiological alternative to the ''classic'' pathway of NO formation from L-arginine ...
Luisa B. Maia, José J.G. Moura
doaj +1 more source
A Crp-dependent two-component system regulates nitrate and nitrite respiration in Shewanella oneidensis. [PDF]
PLoS ONE, 2012 We have previously illustrated the nitrate/nitrite respiratory pathway of Shewanella oneidensis, which is renowned for its remarkable versatility in respiration.
Yangyang Dong +5 more
doaj +1 more source
Resolution of Key Roles for the Distal Pocket Histidine in Cytochrome c Nitrite Reductases [PDF]
, 2015 Cytochrome c nitrite reductases perform a key step in the biogeochemical N-cycle by catalyzing the six-electron reduction of nitrite to ammonium. These multi-heme cytochromes contain a number of His/His ligated c-hemes for electron transfer and a ...
Burlat, Benedicte +7 more
core +5 more sources
Nitrite Biosensing via Selective Enzymes—A Long but Promising Route
Sensors, 2010 The last decades have witnessed a steady increase of the social and political awareness for the need of monitoring and controlling environmental and industrial processes.
M. Gabriela Almeida +3 more
doaj +1 more source
Highly diverse nirK genes comprise two major clades that harbour ammonium-producing denitrifiers [PDF]
, 2016 Background: Copper dependent nitrite reductase, NirK, catalyses the key step in denitrification, i.e. nitrite reduction to nitric oxide. Distinct structural NirK classes and phylogenetic clades of NirK-type denitrifiers have previously been observed ...
Decleyre, Helen +3 more
core +3 more sources
Engineering neuroglobin nitrite reductase activity based on myoglobin models
Biochemistry and Biophysics Reports, 2023 Neuroglobin is a hemoprotein expressed in several nervous system cell lineages with yet unknown physiological functions. Neuroglobin presents a very similar structure to that of the related globins hemoglobin and myoglobin, but shows an hexacoordinate ...
Mark D. Williams +3 more
doaj +1 more source