Results 151 to 160 of about 255,274 (347)

Chemical Methods for Peptide and Protein Backbone Cleavage

open access: yesChemistryEurope, EarlyView.
Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez   +1 more
wiley   +1 more source

Introducing the Cis‐2,3‐Bis(trifluoromethyl)cyclopropyl Chemotype: Late‐Stage Installation and Stereoelectronic Properties

open access: yesChemistryEurope, EarlyView.
The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña   +5 more
wiley   +1 more source

Plasma-activated solutions reverse chronic deltamethrin exposure induced intestinal injury via rebalancing redox homeostasis and counteracting cellular senescence. [PDF]

open access: yesSci Rep
Deng X   +18 more
europepmc   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

open access: yesChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn   +6 more
wiley   +1 more source

Skeletal Editing from Pyridine to Aniline via C‐Insertion and N‐Isomerization

open access: yesChemistryEurope, EarlyView.
A concise protocol is presented that converts pyridines into anilines by externalizing the original pyridine nitrogen at either the "ipso" or "ortho" position, which results in para or meta‐primary aniline products. A key carbene‐insertion step precedes nitrogen migration, preserving both ring size and overall structure.
Yun Luo   +3 more
wiley   +1 more source

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