British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1632-1648, June 2025.Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra +4 more
wiley +1 more source
Novel Metronidazole Conjugates as Antimicrobial Agents
Drug Development Research, Volume 86, Issue 4, June 2025.ABSTRACT Metronidazole (MTZ) is one of the oldest and still used anti‐infective nitroimidazole group drug. Although it is effective against anaerobic bacteria, protozoa, and parasites in clinical settings, it lacks efficacy against aerobic microorganisms.
Erol Akgün +4 more
wiley +1 more source
Oxidative Stress in Antigen Processing and Presentation
MedComm – Oncology, Volume 4, Issue 2, June 2025.Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang +9 more
wiley +1 more source
5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens
, 2023 A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity.
Maxim Gureev +7 more
core +1 more source
ChemMedChem, Volume 20, Issue 9, May 5, 2025.The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley +1 more source
Development and validation of a new method for determining nitrofuran metabolites in bovine urine using liquid chromatography - tandem mass spectrometry [PDF]
, 2013 Background. The use of nitrofurans as veterinary drugs in food-producing animals is banned throughout the European Union. Nevertheless, nitrofuran metabolites have been detected not only in animal products, but also in bovine urine.
Zawadzka, I., Rodziewicz, L.
core
Development of Antibodies and Immunoassays for Monitoring of Nitrofuran Antibiotics in the Food Chain [PDF]
, 2017 Nitrofurans are a broad group of drugs once widely used for the treatment of microbial and proto-zoal infections in many livestock species. However, as concerns grew globally with regard to the potentially carcinogenic and mutagenic effects of their ...
Katrina Campbell +7 more
core +1 more source
Determination of nitrofuran residues in milk by LC/MS/MS and assessment of human health risks in Ankara region, Turkey [PDF]
In this study, we investigated the occurrence of nitrofuran (NF) metabolites, namely 3-amino-2-oxazolidinone (AOZ), semicarbazide (SEM), 5-methylmorpholino-3-amino-2-oxazolidinone (AMOZ), and 1-aminohydantoin (AHD), in raw cow's milk and assessed the ...
Ince, S., Ozdemir, O.
core +1 more source
Hydrophobic carboxymethyl cellulose as a clean-up sorbent in the determination of nitrofuran metabolites in animal-fat samples. [PDF]
RSC Adv, 2023 Thabet OA +5 more
europepmc +1 more source
Simultaneous Screening of Nitrofuran Metabolites in Honey Using Biochip Array Technology: Validation Study According to the Decision 2002/657/EC of the European Union. [PDF]
Iran J Pharm Res, 2022 Yazdanpanah H +7 more
europepmc +1 more source