Results 91 to 100 of about 2,873,864 (246)

Generative and Experimental Validation of High Refractive Index Polymers via Domain Knowledge Approach with Small Data

Advanced Intelligent Discovery, EarlyView.
This research demonstrates that the combination of domain knowledge–based multiple regression, multi‐objective Bayesian optimization, and generative models is a suitable prediction tool for candidates of high refractive index polymers, even with the constraints in the model trained on limited data. The experimental validation can reproduce the proposed
Takuya Yokoo, Seigo Watanabe, Hana Matsunaga, Kenichi Oyaizu   +3 more
wiley   +1 more source

A de‐novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly‐Controlled Kinetic Electron Transfer Gating

Angewandte Chemie, EarlyView.
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha, Rajesh Kancherla, Jorge Escorihuela, Shana Chandran, Mrinal K. Bera, Magnus Rueping, Burkhard König   +6 more
wiley   +2 more sources

Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects

Pharmaceuticals
Pyrimidine is a moiety that occurs in living organisms and has a variety of significant biological properties in pharmacology. Due to the easy handling of synthesis, easily available precursor, and less duration for the reaction, for the synthesis, not ...
Katharigatta N. Venugopala, Vinuta Kamat
doaj   +1 more source

Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles

Frontiers in Chemistry, 2018
The comprehensive review contains the analysis of literature data concerning reactions of heterocyclization of aminoazoles and demonstrates the application of these types of transformations in diversity-oriented synthesis.
Maryna V. Murlykina, Alisa D. Morozova, Ievgen M. Zviagin, Yana I. Sakhno, Sergey M. Desenko, Sergey M. Desenko, Valentyn A. Chebanov, Valentyn A. Chebanov   +7 more
doaj   +1 more source

Access to Unsupported Iminobismuthane and Tetraazabismole Species Enabled by a Rigid and Bulky Organobismuthinidene

Angewandte Chemie, EarlyView.
By employing a sterically bulky monocoordinate bismuthinidene, the synthesis and characterization of the first examples of an unsupported iminobismuthane and tetraazabismole was achieved via reactions with organic azides. The corresponding amines could be accessed by reduction, leading to the regeneration of the Bi(I) compound. Hence, we also highlight
Marcel Potocnik, Kristian L. Mears, Davide Spinnato, Gabriele Deplano, Nils Nöthling, Markus Leutzsch, Maurice van Gastel, Khai‐Nghi Truong, Serena DeBeer, Josep Cornella   +9 more
wiley   +2 more sources

A Mesoionic Platform for Persistent Anionic Nitrogen‐Centered Radicals

Angewandte Chemie, EarlyView.
Charge did not meet spin: Mesoionic 1,2,3‐triazines undergo reversible one‐electron reduction to persistent anionic nitrogen‐centered radicals. Electron paramagnetic resonance, single‐crystal x‐ray diffraction, and calculations reveal nitrogen‐localized spin and structural reorganization, while crystalline salts show clean redox cycling.
Deepak Ranolia, Aleksandr Koronatov, Yogendra Kumar, Mamta Sham Lal, Boris Tumansky, Alexander Kaushansky, Natalia Fridman, Malachi Noked, Mark Gandelman   +8 more
wiley   +2 more sources

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Synthesis of Nitrogen-Containing Heterocycles Through Catalytic Dehydrative Cyclization and Carbon-Hydrogen Oxidative Cycloaddition Reactions

, 2022
The synthetic importance of dehydrative cyclization reactions in the formation of nitrogen-containing heterocycles has been thoroughly documented. Most classical methods require the use of stoichiometric or excess amounts of dehydrating reagents. Here we
Rodriguez del Rey, Freddy O.
core  

The oxime portmanteau motif : released heteroradicals undergo incisive EPR interrogation and deliver diverse heterocycles [PDF]

, 2014
OA funded through the RCUK OA block grant.Selective syntheses are now available for compounds of many classes, based on C-centered radicals, exploiting a diverse range of mechanisms.
John C. Walton, Walton, John Christopher
core   +1 more source

Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs

Angewandte Chemie, EarlyView.
Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang, Bin Liu, Elise M. Ackerman, Yichen Xiang, Hung V.‐T. Nguyen, Yivan Jiang, Angela N. Koehler, Jeremiah A. Johnson   +7 more
wiley   +2 more sources