Results 81 to 90 of about 3,012,654 (221)

Intramolecular Schmidt Reaction: Applications in Natural Product Synthesis

CHIMIA, 2006
The intramolecular Schmidt reaction was first described at the beginning of the 1990s and rapidly proved to be a powerful tool for the fast assembly of complex nitrogen-containing heterocycles.
Erich Nyfeler, Philippe Renaud
doaj   +1 more source

Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor

Beilstein Journal of Organic Chemistry, 2020
A convergent strategy is reported for the construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines.
Dalel El-Marrouki, Sabrina Touchet, Abderrahmen Abdelli, Hédi M’Rabet, Mohamed Lotfi Efrit, Philippe C. Gros   +5 more
doaj   +1 more source

Photochemical Regiodivergent Functionalization of Quinolines with Aryl Ketones

Advanced Science, EarlyView.
A photocatalytic system‐controlled approach enables regiodivergent C2‐ and C4‐functionalization of quinolines with aryl ketones by optimizing aryl thiol photocatalysts and formate reductants. Using ortho‐(isopropoxycarbonyl)thiophenol with excess formate facilitates C4‐dearomatization, yielding bridged 1,3‐oxazepanes. In contrast, meta‐(methoxycarbonyl)
Yi‐Lin Zhao, Bei‐Bei Zhang, Xueying Guo, Kui Dong, Zhi‐Xiang Wang, Li‐Zhu Wu, Qiang Liu   +6 more
wiley   +1 more source

Nitrogen Heterocycles by Palladium-Catalyzed Cyclization of Amino-Tethered Vinyl Halides and Ketone Enolates

, 2016
The scope and limitations of Pd(0)-catalyzed intramolecular coupling of amino-tethered vinyl halides and ketone enolates as a methodology for the synthesis of nitrogen heterocycles have been studied.
Daniel Solé (2448130), Faïza Diaba (2458549), Josep Bonjoch (1508560)   +2 more
core   +2 more sources

Second‐Sphere Aromatic Substitutions That Tune H‐Atom Transfer Reactivity Observed for a Series of S = 1 Nonheme FeIV=O Complexes: An Enthalpy‐Entropy Compensation Effect

Angewandte Chemie, EarlyView.
A series of oxoiron(IV) complexes was synthesized to determine the impact of electronically tuned aromatic substitution in the secondary sphere of the ligand. Despite possessing identical electronic properties, they show significant differences in C─H oxidation reactions.
Abhishek Das, Jin Xiong, Victor G. Young Jr., Yisong Guo, Marcel Swart, Lawrence Que Jr.   +5 more
wiley   +2 more sources

Generative and Experimental Validation of High Refractive Index Polymers via Domain Knowledge Approach with Small Data

Advanced Intelligent Discovery, EarlyView.
This research demonstrates that the combination of domain knowledge–based multiple regression, multi‐objective Bayesian optimization, and generative models is a suitable prediction tool for candidates of high refractive index polymers, even with the constraints in the model trained on limited data. The experimental validation can reproduce the proposed
Takuya Yokoo, Seigo Watanabe, Hana Matsunaga, Kenichi Oyaizu   +3 more
wiley   +1 more source

Organocatalytic Asymmetric Annulation of 2-Aminophenyl-Derived α,β-Unsaturated Systems: Access to Chiral Benzene-fused Nitrogen-containing Heterocycles

Nitrogen-containing heterocycles are ubiquitous structural motifs in biologically active natural products, pharmaceuticals, and functional molecules. Among them, benzene-fused nitrogen-containing heterocycles, particularly quinoline-derived frameworks ...
Minhyeok Jeon, Sung-Gon Kim
core   +1 more source

Catalysed low temperature H-2 release from nitrogen heterocycles

, 2006
In an experimental and computational study, nitrogen- and oxygen-containing heterocycles were compared with carbocycles as liquid substrates for hydrogen release with heterogeneous catalysts. Heteroatom substitution, particularly by nitrogen, favours low
Poyatos, Macarena, Luo, Yi,, Moores, Audrey, Crabtree, Robert H.   +3 more
core   +1 more source

Access to Unsupported Iminobismuthane and Tetraazabismole Species Enabled by a Rigid and Bulky Organobismuthinidene

Angewandte Chemie, EarlyView.
By employing a sterically bulky monocoordinate bismuthinidene, the synthesis and characterization of the first examples of an unsupported iminobismuthane and tetraazabismole was achieved via reactions with organic azides. The corresponding amines could be accessed by reduction, leading to the regeneration of the Bi(I) compound. Hence, we also highlight
Marcel Potocnik, Kristian L. Mears, Davide Spinnato, Gabriele Deplano, Nils Nöthling, Markus Leutzsch, Maurice van Gastel, Khai‐Nghi Truong, Serena DeBeer, Josep Cornella   +9 more
wiley   +2 more sources

Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects

Pharmaceuticals
Pyrimidine is a moiety that occurs in living organisms and has a variety of significant biological properties in pharmacology. Due to the easy handling of synthesis, easily available precursor, and less duration for the reaction, for the synthesis, not ...
Katharigatta N. Venugopala, Vinuta Kamat
doaj   +1 more source