Results 61 to 70 of about 3,012,654 (221)

Enhancing Reaction Kinetics and Structural Control in N‐Carboxyanhydride (NCA) Polypeptide Synthesis by Structurally Tuned Azamacrocyclic Ligands

Angewandte Chemie, EarlyView.
Azamacrocycles provide a tunable platform for rapid N‐carboxyanhydride (NCA) Ring‐Opening Polymerization (ROP). Changing the methylation pattern switches the macrocycle from an external catalyst (N14Me3) to a covalent initiator‐catalyst (IniCat, N14Me1), delivering controlled polypeptide growth under open‐vessel conditions.
Paulina Maksym, Adam Gorczynski, Robert D. Murphy, Gianluca Bartolini Torres, Roksana Wygoda, Karol Garbaczewski, Giuseppe Forte, Giuseppe Consiglio, Yixuan Chen, Sébastien Perrier, Andreas Heise   +10 more
wiley   +2 more sources

Formal pyridine meta-azidation and its application for the synthesis of diazepines, ring-fused δ-carbolines and 1,2,3-triazolylpyridines

Nature Communications
The nitrogen atom serves as an important structural element in pharmacologic studies, highlighting the critical role of nitrogen-containing heterocycles in drug discovery.
Shu-Min Guo, Pengwei Xu, Constantin G. Daniliuc, Armido Studer   +3 more
doaj   +1 more source

Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

Molecules, 2006
A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation.
Jingkang Shen, Jia Li, Jian Liu, Yongliang Zhang, Jingya Li, Xin Wang, Xin Li, Beiying Qiu, Li Zhang   +8 more
doaj   +1 more source

Raney Nickel-Catalyzed Deuterium Labeling of Nitrogen-Containing Heterocycles and Pharmaceuticals under Continuous Flow Conditions [PDF]

Deuterium-labeled compounds play a pivotal role in physical organic chemistry, life sciences, and materials science. This has resulted in a surge of interest in deuterium-labeled active pharmaceutical ingredients in recent years.
Gellért, Sipos, Mounir, Raji, Dávid, Suskó, Eszter, Csizmadia, Ferenc, Minya, Ádám, Mészáros   +5 more
core   +2 more sources

Supramolecular Chiral Assemblies from Benzoselenadiazole‐Alanine‐Acylhydrazone Conjugates Enable Cardioprotection

Advanced Science, EarlyView.
The C3‐symmetric conjugate TASe, which integrates benzoselenadiazole, alanine, and acylhydrazone modules, self‐assembles into a chalcogen‐/hydrogen‐bonded porous framework in the solid state and uniform chiral nanospheres in aqueous media. These assemblies protect cardiomyocytes from doxorubicin‐induced oxidative injury by scavenging intracellular ...
Jinkui Teng, Renjing Yang, Yu Du, Jingzhong Duan, Yiming Xu, Zhihua He, Guanghui Wang, Wenjing Tian, Aijie Liu, Haifeng Chen, Yun‐Bao Jiang, Xiaosheng Yan   +11 more
wiley   +1 more source

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +2 more sources

Prospects for the use of growth stimulators based on nitrogen-containing heterocycles in plant propagation technologies

Біологічні системи: теорія та інновації
Nitrogen-containing heterocycles have attracted the attention of researchers as compounds widely represented in the structures of both natural and synthetic plant growth regulators.
M. Zavhorodnii, V. Gencheva, V. Shupeniuk, O. Brazhko, V. Horban   +4 more
doaj   +1 more source

Metal-free intermolecular formal cycloadditions enable an orthogonal access to nitrogen heterocycles

Nature Communications, 2016
Nitrogen containing heterocycles play key roles as both bioactive compounds and synthetic building blocks in organic chemistry. Here, the authors report the synthesis of a range of heterocyclic structures via metal free cycloadditions and provide ...
Lan-Gui Xie, Supaporn Niyomchon, Antonio J. Mota, Leticia González, Nuno Maulide   +4 more
doaj   +1 more source

Uncovering Untapped Carboxylic Acid Reductases (CARs) for One-Step Biosynthesis and Diversification of Bioactive Nitrogen-Containing Heterocycles

, 2023
Nitrogen-containing heterocycles (N-heterocycles) are essential in drug discovery, with a majority of best-selling small-molecule drugs containing at least one N-heterocycle.
Tian, Yongqi, Tang, Xiaoyu, Zhong, Zheng, Shi, Yuqi, Li, Yong-Xin, He, Jiaze, Zhang, Dengwei, Cai, Peiyan, Song, Zhi-Man   +8 more
core   +1 more source

Protonation Modification of Commercial OPBI as Binders Toward High‐Performance High‐Temperature PEM Fuel Cells

Advanced Science, EarlyView.
Commercial OPBI binders is regulated via a facile formic‐acid protonation strategy without disrupting the polymer backbone. Protonation introduces positively charged benzimidazole sites, inducing interchain electrostatic repulsion that loosens chain packing, enlarges intermolecular spacing, and promotes uniform binder dispersion over catalyst surfaces.
Jinzhen Huang, Minhui Liang, Jingjing Lin, Zhihuan Pan, Jinwu Peng, Lei Wang   +5 more
wiley   +1 more source