Results 71 to 80 of about 3,582,154 (355)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Methane and Nitrogen Abundances On Pluto and Eris [PDF]

, 2010
We present spectra of Eris from the MMT 6.5 meter telescope and Red Channel Spectrograph (5700-9800 angstroms; 5 angstroms per pix) on Mt. Hopkins, AZ, and of Pluto from the Steward Observatory 2.3 meter telescope and Boller and Chivens spectrograph ...
Brown, Brunetto, C. K. Maleszewski, D. E. Evans, D. M. Cornelison, F. Vilas, J. A. Burt, M. J. Bovyn, M. R. Abernathy, Merlin, Olkin, Prokhvatilov, S. C. Tegler, Schaller, Stansberry, W. M. Grundy, W. Romanishin, Z. Thompson   +17 more
core   +2 more sources

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

On the origin of nitrogen [PDF]

Astronomy & Astrophysics, 2002
The problem of the origin of nitrogen is considered within the framework of an empirical approach. The oxygen abundances and nitrogen to oxygen abundances ratios are derived in HII regions of a number of spiral galaxies through the recently suggested P-method using more than six hundred published spectra.
L. S. Pilyugin, José M. Vílchez, Trinh X. Thuan   +2 more
openaire   +4 more sources

Total Nitrogen Concentrations in Wastewater Treatment Plant Effluent in the Great Bay Estuary Watershed in 2008 [PDF]

, 2008
Nitrogen enrichment is a growing concern for the Great Bay Estuary. For the 2006 State of the Estuaries report (NHEP, 2006), the NHEP calculated the nitrogen load from wastewater treatment facilities (WWTF) using data on total dissolved nitrogen in WWTF ...
Trowbridge, Philip
core   +1 more source

Oxygen molecule dissociation on carbon nanostructures with different types of nitrogen doping

, 2011
Energy barrier of oxygen molecule dissociation on carbon nanotube or graphene with different types of nitrogen doping is investigated using density functional theory.
Blochl, Chan, Czerw, Feng, Genga, Gong, Henkelman, Ikeda, Iwazaki, Jang, Jinlong Yang, Kresse, Kresse, Kresse, Kundu, Liu, Luo, Lyth, Maldonado, Maldonado, Monkhorst, Niwaa, Okamoto, Perdew, Qu, Rao, Shan, Shuang Ni, Sorescu, Steele, Tang, Wang, Wang, Wang, Winter, Xiong, Yang, Yang, Yu, Yu, Yu, Zhang, Zhenyu Li, Zhu   +43 more
core   +1 more source

Anthropogenic nitrogen autotrophy and heterotrophy of the world's watersheds: Past, present, and future trends [PDF]

, 2010
Anthropogenic nitrogen autotrophy of a territory is defined as the nitrogen flux associated with local production of harvested crops and grass consumed by livestock grazing (in kg N/km(2)/yr).
Beusen, A., Billen, G., Bouwman, L., Garnier, J.   +3 more
core   +3 more sources

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Spectrum of Nitrogen [PDF]

Nature, 1873
IN a letter to NATURE (April 17th), Mr. Stearn throws some doubts on the accuracy of my experiments regarding the spectrum of nitrogen. I shall take the earliest opportunity of repeating and completing my experiments, and hope then to bring the question to a satisfactory close.
openaire   +5 more sources