Recent Discovery of Nitrogen Heterocycles from Marine-Derived Aspergillus Species [PDF]
Marine DrugsNitrogen heterocycles have drawn considerable attention because of their structurally novel and significant biological activities. Marine-derived fungi, especially the Aspergillus species, possess unique metabolic pathways to produce secondary ...
Jueying Shi +8 more
doaj +2 more sources
Sulfur-Nitrogen Heterocycles [PDF]
Molecules, 2005 n ...
Tomás Torroba +1 more
doaj +2 more sources
N-tert-Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles
Beilstein Journal of Organic Chemistry, 2021 The synthesis of nitrogen-containing heterocycles, including natural alkaloids and other compounds presenting different types of biological activities have proved to be successful employing chiral sulfinyl imines derived from tert-butanesulfinamide ...
Joseane A. Mendes +4 more
doaj +2 more sources
Photoredox Radical/Polar Crossover Enables Construction of Saturated Nitrogen Heterocycles. [PDF]
Org Lett, 2019 Photoredox-mediated radical/polar crossover (RPC) processes offer new avenues for the synthesis of cyclic molecules. This process has been realized for the construction of medium-sized saturated nitrogen heterocycles.
Pantaine LRE +4 more
europepmc +2 more sources
Catalytic Asymmetric Synthesis of α-Arylpyrrolidines and Benzo-fused Nitrogen Heterocycles. [PDF]
Angew Chem Int Ed Engl, 2019 Herein we report a practical two-step synthetic route to α-arylpyrrolidines consisting of Suzuki-Miyaura cross-coupling and enantioselective copper-catalyzed intramolecular hydroamination reactions. The excellent stereoselectivity and broad scope for the
Dai XJ, Engl OD, León T, Buchwald SL.
europepmc +2 more sources
Recent advances in the application of ring-closing metathesis for the synthesis of unsaturated nitrogen heterocycles. [PDF]
Synthesis (Stuttg), 2019 This short review summarizes recent advances relating to the application of ring-closing olefin-olefin and carbonyl-olefin metathesis reactions towards the synthesis of unsaturated five- and six-membered nitrogen heterocycles.
Groso EJ, Schindler CS.
europepmc +2 more sources
Harnessing unprotected deactivated amines and arylglyoxals in the Ugi reaction for the synthesis of fused complex nitrogen heterocycles [PDF]
Beilstein Journal of Organic ChemistryPiperazines and diazepines are examples of nitrogen heterocycles present in many marketed drugs highlighting their importance in the discovery of novel bioactive compounds.
Javier Gómez-Ayuso +5 more
doaj +2 more sources
Synthesis, Reactivity, Functionalization, and ADMET Properties of Silicon-Containing Nitrogen Heterocycles. [PDF]
J Am Chem Soc, 2018 Silicon-containing compounds have been largely ignored in drug design and development, despite their potential to improve not only the potency but also the physicochemical and ADMET (absorption, distribution, metabolism, excretion, toxicity) properties ...
Barraza SJ, Denmark SE.
europepmc +2 more sources
Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents
Molecules, 2022 Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence
Tuyen N. Tran, Maged Henary
doaj +2 more sources
Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery.
Drug Discovery Today, 2022 Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively worsens with time. Clinical options are limited and only provide symptomatic relief to AD patients.
Shikha Kumari +5 more
semanticscholar +1 more source