Results 41 to 50 of about 23,082 (272)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Integrated Visible Light and Oxidant Protection Through Multifunctional Sunscreens

Advanced Healthcare Materials, EarlyView.
High‐energy visible radiation (HEVR), although less energetic than UV light, penetrates deeper into the skin and contributes to photoaging, pigmentation disorders, and oxidative stress. The development of new HEVR‐targeted filters, therefore, represents not only a scientific challenge but also a pressing public health and cosmetic industry need.
Beatriz Peñín, Raúl Losantos, Ignacio Funes‐Ardoiz, Diego Sampedro   +3 more
wiley   +1 more source

Synthesis of α-Trifluoromethylated Nitrogen Heterocycles

, 2016
The syntheses of various α-trifluoromethylated nitrogen heterocycles have been achieved from readily available α-(trifluoromethyl)homoallylamine through a ring-closing ...
Ségolène Gille (3035658), Thierry Billard (1811233), Aurélien Ferry (3035661), Bernard R. Langlois (2404912)   +3 more
core   +1 more source

Brønsted acid-enhanced copper-catalyzed atroposelective cycloisomerization to axially chiral arylquinolizones via dearomatization of pyridine

Nature Communications, 2022
Methods to assemble axially chiral biaryl molecules with nitrogen-containing heterocycles can have implications in ligand development for homogeneous catalysis. Here the authors report enantioselective syntheses of axially chiral arylquinolizones, via an
Xiao-Long Min, Xiu-Lian Zhang, Wenbin Yi, Ying He   +3 more
doaj   +1 more source

Nitrogenous Heterocyclic Moiety for Drug Discovery

Anti-Cancer Agents in Medicinal Chemistry, 2021

Yongtao, Duan, Hai-Liang, Zhu
openaire   +2 more sources

Step‐Edge Functionalization by N‐Heterocyclic Carbenes Enhances Catalytic Activity in Electrochemical CO2 Reduction

Advanced Materials, EarlyView.
Atomically precise functionalization by N‐heterocyclic carbenes enhances the catalytic efficiency of macroscopically defined step edges toward electrochemical CO2${\rm CO}_2$ reduction. Sub‐molecular imaging reveals conformational differences between specific NHCs, which can be correlated with their catalytic performance. Photoelectron spectroscopy and
Philipp Wiesener, Ankita Das, Elena Kolodzeiski, Duong Tran, Ying Pan, Harald Fuchs, Nieves López‐Salas, Saeed Amirjalayer, Frank Glorius, Harry Mönig   +9 more
wiley   +1 more source

Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles

Beilstein Journal of Organic Chemistry, 2012
The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction.
Anthony R. Martin, Anthony Chartoire, Alexandra M. Z. Slawin, Steven P. Nolan   +3 more
doaj   +1 more source

1,1’-(3-Methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone as a Building Block in Heterocyclic Synthesis. Novel Synthesis of Some Pyrazole and Pyrimidine Derivatives

Molecules, 2011
A series of new bis(heterocycles) featuring thieno[2,3-b]thiophene rings was synthesized in a combinatorial manner. Intramolecular cyclization of enaminone derivatives with appropriate N-nucleophiles afforded the target compounds.
Saeed Alshahrani, Assem Barakat, Yamin Siddiqui, Yahia Nasser Mabkhot, Abdullah Mohammed Al-Majid   +4 more
doaj   +1 more source

Light Switchable Ionic Conductivity of Arylazopyrazole Modified Polysiloxanes

Advanced Materials Technologies, EarlyView.
We present a polysiloxane functionalized with a novel arylazopyrazole dye that undergoes reversible photoisomerization. Upon lithium bis(trifluoromethanesulfonyl)imide addition and UV irradiation, the polymer exhibits a shift in tan(d) toward higher frequencies and enhanced ionic conductivity.
Malte S. Beccard, Thulasinath Raman Venkatesan, Michael Bauer, Valentin Razvan Lupu, Philipp Scheidegger, Francesco Taddei, Frank A. Nüesch, Dorina M. Opris   +7 more
wiley   +1 more source

From Cycloalkanols to Heterocycles via Nitrogen Insertion

, 2023
A variety of cyclic alcohols are found to undergo nitrogen insertion by subjection to O-mesitylsulfonylhydroxylamine. Critical to a successful process is the use of fluorinated alcoholic solvents, which ensures sufficient substrate activation to allow ...
Alexander Sandvoß (16704261), Johannes M. Wahl, Johannes M. Wahl (13262744), Alexander Sandvoß   +3 more
core   +1 more source