Results 121 to 130 of about 2,262,605 (283)
Aromatic Nitrogen Mustards [PDF]
This work was stimulated by the search for more potent drug/prodrug combinations in the field of the aromatic nitrogen mustards, for potential used in antibody directed enzyme prodrug therapy. 4-Acyl prodrugs of N,N-bis(2-chloroethyl)-4-amino-aniline, possible substrates for the bacterial enzyme acylarylamidase E.C.
openaire +1 more source
Nitrogen mustard drug resistance in B-cell chronic lymphocytic leukemia
Previous studies of nitrogen mustard drug resistance in B-cell chronic lymphocytic leukemia (B-CLL) indicated that resistance was a result of enhanced DNA repair associated with increased expression of two DNA repair genes, ERCC-1 and alkyl-N-purine DNA ...
Bramson, Jonathan
core
Novel piperidine–embedded isoxazol–triazole conjugates (6a‐6o) were designed, synthesized, and evaluated for anticancer activity against MCF‐7 breast cancer cells, with selectivity assessed using noncancerous HEK293 cells. Compound 6m showed the most potent antiproliferative activity (GI50 < 10 µg/mL; SI > 5), comparable to doxorubicin, highlighting ...
Jay R. Ghonia +2 more
wiley +1 more source
A study of the chemistry of nitrogen mustard by N.M.R. spectroscopy [PDF]
This thesis describes the use of high-field n.m.r. spectroscopy, in part combined with stable isotope labelling, to study the solution chemistry of nitrogen mustard (2-chloro-(N-2-chloroethyl)-N-methylethanamine).
Kebbell, Michael James
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Effect of Cycocel and Nitrogen on Carbonic Anhydrase Activity and Mustard Biomass [PDF]
Addition of 30 mM nitrogen (in the form of NaNO3) inhibited after 80 d the activities of carbonic anhydrase and nitrate and nitrate reductase and net photosynthetic rate in mustard (Brassica juncea L.).
,Shazia Rashid3,K.A.Bhat2,S.M.Razvi2,Nawsheeba Wani2,Sabina Akhter2,S.A.Wani4, W.A.Payne5, N.A.Lone1,M.R.Mir1*,M.A.Bhat2,S.Singh1
core
The pollination of mustard by honeybees
The presence of honeybees in bee-proof cages put over plots of mustard substantially increased the seed yield of Brassica alba, but not that of B. juncea.
Free, J. B., Spencer-Booth, Y.
core +1 more source
Synchronous Vaginal and Liver Metastases in Rectosigmoid Cancer: Case Report and Literature Review
ABSTRACT Vaginal metastasis from colorectal cancer is extremely rare. We report the case of a 58‐year‐old postmenopausal woman with rectosigmoid adenocarcinoma and synchronous liver and vaginal metastases who initially presented with gastrointestinal symptoms followed by vaginal bleeding.
Tamader Alyaarabi +7 more
wiley +1 more source
Macrocyclic nitrogen mustard prodrugs as hypoxia selective anti-cancer agents [PDF]
The low selectivity of chemotherapy is an ongoing problem in the treatment of cancer. Prodrugs that are activated in vivo provide a therapeutic advantage for selective cytotoxicity.
Parker, Laura Louise
core +2 more sources
Native earthworms and roe deer in temperate forests: Friends in the sun, foes in the shade
Abstract Given increasing deer populations and rising canopy openness through tree mortality in European forests, understanding how these changes affect above‐belowground communities and ecosystem functioning is becoming more important. Earthworms comprise the largest animal biomass in European forest soils and play a central role in decomposition ...
Ludwig Lettenmaier +15 more
wiley +1 more source
Sanguinarine, a toxic alkaloid present in argemone, can lead to epidemic dropsy or chronic diseases through DNA intercalation and immune system suppression. Regulatory efforts face challenges due to economic motivations for adulteration as well as technical, social, and infrastructure barriers.
Gururaj Pejavara Narayana +4 more
wiley +1 more source

