Results 191 to 200 of about 22,395 (232)
Synthesis and Molecular Modeling of a Nitrogen Mustard DNA Interstrand Crosslink
Chemistry - A European Journal, 2010 Nitrogen mustard reloaded: Over 60 years after nitrogen mustards (NMs) were the first agents used to treat tumors by chemotherapy, we provide a method to generate the main DNA adduct formed by NMs and validate them by using molecular dynamics simulations
Arthur J Campbell +2 more
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Journal of Pharmaceutical Sciences, 1967
As potential anticancer agents, three new 3-thenyl nitrogen mustards have been prepared from the corresponding diethanolamine derivatives. The NMR data for these compounds are reported.
W L, Nobles, C M, Darling
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As potential anticancer agents, three new 3-thenyl nitrogen mustards have been prepared from the corresponding diethanolamine derivatives. The NMR data for these compounds are reported.
W L, Nobles, C M, Darling
openaire +2 more sources
Inactivation of Complement by Nitrogen Mustard
Nature, 1948THE recent clinical use of the nitrogen mustards for the treatment of Hodgkin‘s and other neoplastic diseases1 has focused attention on these compounds and more particularly on their biological action. The intensive study of these vesicants made during the War2, when they were regarded as potential chemical warfare agents, has been continued in the ...
W M, WATKINS, A, WORMALL
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EXPERIENCES WITH NITROGEN MUSTARD THERAPY
Journal of the American Medical Association, 1949Until recently, the palliative treatment of lymphoblastoma and other neoplastic diseases has depended almost entirely on the use of irradiation by roentgen rays or radium. With the recent introduction of the nitrogen mustards as potential therapeutic agents in this field, a concentrated effort has been made by various groups of investigators1to ...
C C, SHULLENBERGER +2 more
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Effect of nitrogen mustard of hyaluronate
Biochemical Pharmacology, 1969Abstract The effect in vitro of nitrogen mustard (HN2) treatment on physical parameters of partially purified hyaluronate from human umbilical cords and of synovial fluid from patients with rheumatoid arthritis was studied. Intrinsic viscosities, gel filtration elution patterns (Sepharose 2B) and acrylamide gel disk electrophoresis runs on HN2 ...
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The Nitrogen Mustards: Clinical Use
Radiology, 1948One unexpected and beneficial byproduct of World War II is a method of chemotherapy that undoubtedly is here to stay, at least for some years. This statement refers to the use of nitrogen mustards as palliative agents for certain types of malignant neoplastic processes. While these agents may be said to have failed to measure up to early hopes for them,
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