Results 131 to 140 of about 19,239 (193)
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Biochemical Pharmacology, 1960
Abstract The azo-mustard 4-di-2″-chloroethylaminoazobenzene-2′-carboxylic acid was found to be mutagenic in Drosophila melanogaster males. The mutagenic effect was found only in pre-meiotic germ cell stages and, of these, late spermatids were the most sensitive. Sterility or egg unhatchability was found to be due to aspermia.
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Abstract The azo-mustard 4-di-2″-chloroethylaminoazobenzene-2′-carboxylic acid was found to be mutagenic in Drosophila melanogaster males. The mutagenic effect was found only in pre-meiotic germ cell stages and, of these, late spermatids were the most sensitive. Sterility or egg unhatchability was found to be due to aspermia.
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Bioorganic & Medicinal Chemistry Letters, 1997
Abstract A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-( ortho -hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed low cytotoxicity, it must be considered as appropriate for an ADEPT approach.
Jean Claude Florent +6 more
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Abstract A prodrug consisting of a β-D-glucuronic acid linked to a self-immolative spacer (a N-( ortho -hydroxyphenyl)-N-methylcarbamate) and a phenolic nitrogen mustard was synthesised. As this prodrug was easily cleaved by a β-glucuronidase enzyme and displayed low cytotoxicity, it must be considered as appropriate for an ADEPT approach.
Jean Claude Florent +6 more
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CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES.1 VI. THE REACTIONS OF THE NITROGEN MUSTARD GASES WITH CHEMICAL COMPOUNDS OF BIOLOGICAL INTEREST [PDF]
The Journal of Organic Chemistry, 1946 JOSEPH S. FRUTON +3 more
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CLINICAL TRIAL OF A NEW NITROGEN-MUSTARD COMPOUND
The Lancet, 1956Sandor Eckhardt +3 more
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201. Some compounds related to the aromatic “nitrogen mustards.”
J. Chem. Soc., 1950John J. Roberts, George A. R. Kon
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A TECHNIQUE FOR INTRAPLEURAL ADMINISTRATION OF NITROGEN MUSTARD COMPOUNDS
The American Journal of the Medical Sciences, 1957openaire +3 more sources
Mutagenicity of heterocyclic nitrogen mustards (ICR compounds) in cultured mammalian cells.
Cancer research, 1978The mutagenicity of six heterocylic nitrogen mustards (ICR compounds) has been determined in a cultured mammalian cell system by use of resistance to the purine analog 6-thioguanine to select for mutation induction at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster ovary cells. The six compounds tested are ICR 191, 170, 292,
J P, O'Neill, J C, Fuscoe, A W, Hsie
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Properties and Promise of Catenated Nitrogen Systems As High-Energy-Density Materials
Chemical Reviews, 2020Michael J Zdilla
exaly
Progress and Prospective of Nitrogen-Based Alternative Fuels
Chemical Reviews, 2020Agustin Valera-medina +2 more
exaly
Nitrogen Fixation via Splitting into Nitrido Complexes
Chemical Reviews, 2021Sebastian J K Forrest +2 more
exaly