Results 161 to 170 of about 30,885 (243)

New compounds: N-arylglyoxylohydroxamyl derivatives of nitrogen mustard

open access: closedJournal of Pharmaceutical Sciences, 1967
The synthesis and physical properties of some N,N - bis (2 - chloroethyl)arylglyoxylohy-droxamamides are described.
J P, Larocca, C A, Gibson
openaire   +3 more sources

The influence of some sulfur-containing compounds on the toxicity of nitrogen mustards

open access: closedToxicology and Applied Pharmacology, 1963
Abstract Measurements of the effect of nitrogen mustards on the cholinesterase activity of the small intestine of rats indicated that HN1 and HN2 cause a decrease in enzyme activity of the intestine that is maximal at 2–4 days after administration and is reversible after sublethal doses of the nitrogen mustards.
B E, HIETBRINK, A B, RAYMUND
openaire   +3 more sources

A chlorine-35 nuclear quadrupole resonance study of some nitrogen mustard compounds

open access: closedJournal of Magnetic Resonance (1969), 1977
Abstract A linear relationship has been established between the 35Cl nuclear quadrupole resonance frequency and the sum of the Hammet δ parameters for several aromatic nitrogen mustard compounds. This relationship is given by f q =1.024 ∑ i=1 n where fq is the quadrupole resonance frequency in megahertz, δ1 is the Hammett δ ...
David W Sheppard, Philip J Bray
openaire   +2 more sources

Mutagenicity of heterocyclic nitrogen mustards (ICR compounds) in cultured mammalian cells.

open access: closedCancer research, 1978
The mutagenicity of six heterocylic nitrogen mustards (ICR compounds) has been determined in a cultured mammalian cell system by use of resistance to the purine analog 6-thioguanine to select for mutation induction at the hypoxanthine-guanine phosphoribosyltransferase locus in Chinese hamster ovary cells. The six compounds tested are ICR 191, 170, 292,
J P, O'Neill, J C, Fuscoe, A W, Hsie
openaire   +2 more sources

Comparative Therapeutic Activity of the Nitrogen Mustards and Allied Compounds

open access: closedMedical Clinics of North America, 1956
M P, SYKES   +2 more
openaire   +3 more sources

THE TOXICITY AND PHARMACOLOGICAL ACTION OF THE NITROGEN MUSTARDS AND CERTAIN RELATED COMPOUNDS

open access: closedThe Journal of Pharmacology and Experimental Therapeutics, 1947
WILLIAM P. ANSLOW   +3 more
openaire   +2 more sources
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Phosphorus-nitrogen compounds. 24. Phosphoramide mustard carrier derivatives

Journal of Medicinal Chemistry, 1984
Diethylstilbestrol, psoralen, and propranolol were used as potential carrier molecules for selective concentrations of a nitrogen mustard moiety in breast, skin, and lung tissues, respectively. The propranolol derivative gave two racemic mixtures, which were tested to ascertain any differences in anticancer activity.
L A, Cates   +3 more
openaire   +2 more sources

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