Results 11 to 20 of about 19,239 (193)
Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
Pharmaceuticals, 2022 Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves the combination of two drug ...
Ankit Kumar Singh +13 more
doaj +1 more source
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market.
Paola Rizzarelli +2 more
wiley +1 more source
Discovery of a potent olaparib–chlorambucil hybrid inhibitor of PARP1 for the treatment of cancer
Frontiers in Pharmacology, 2023 Introduction: Development of Poly (ADP-ribose) polymerase (PARP) inhibitors has been extensively studied in cancer treatment. Olaparib, the first approved PARP inhibitor, showed potency in the inhibition of both BRCA (breast cancer associated)-mutated ...
Hongyu Qin +5 more
doaj +1 more source
Ecosystem Services Provided by Cover Crops and Biofumigation in Sunflower Cultivation
Agronomy, 2022 In south-western France, sunflowers are usually grown in short rotations and after a long fallow period during which soils are left bare. This practice can favour diseases, caused by soilborne fungi, such as sunflower verticillium wilt (SVW), as well as ...
Neila Ait Kaci Ahmed +4 more
doaj +1 more source
Studies on some potentially cytotoxic nitrogen mustards and related compounds
, 1972 Imperial Users ...
Edwards, Peter David +1 more
openaire +2 more sources
17α‐Ethynylestradiol‐induced changes in Brassica rapa during the seedling growth stage
Agrosystems, Geosciences & Environment, 2022 Estrogens and estrogen‐like compounds are considered contaminants of emerging concern due to their endocrine disrupting capability and potential to build up in soil and aquatic environments, although little is known about the effects of estrogenic ...
Chathurika Wijewardana +3 more
doaj +1 more source
Evaluation of fall‐seeded cover crops for grassland nesting waterfowl in eastern South Dakota
Wildlife Society Bulletin, EarlyView., 2023 Cover crops are experiencing a revival among Midwestern farmers, and we assessed their attractiveness and safety for nesting ducks in South Dakota. Nest success was markedly lower in cover crops than in perennial cover during both years of our study, including 2019 which was a best‐case scenario for cover crops, with extremely wet conditions delaying ...
Charles W. Gallman +3 more
wiley +1 more source
Scientific Reports, 2021 Little is known about the interactive effects of exogenous nitric oxide (NO) and abscisic acid (ABA) on nitrogen (N) metabolism and related changes at molecular and biochemical levels under drought stress. The present study highlights the independent and
Seema Sahay +3 more
doaj +1 more source
Therapeutic Potential of Nitrogen Mustard Based Hybrid Molecules
Frontiers in Pharmacology, 2018 As medicine advances, cancer is still among one of the major health problems, posing significant threats to human health. New anticancer agents features with novel scaffolds and/or unique mechanisms of action are highly desirable for the treatment of ...
Yiming Chen +3 more
doaj +1 more source
Effect of cytostatic drugs on microbial behaviour in membrane bioreactor system [PDF]
, 2010 The aim of this work is to evaluate the influence of cyclophosphamide and its principal metabolites (CPs) on microbial behaviour in a membrane bioreactor system. Two laboratory-scale membrane bioreactors (MBR) were run in parallel with a sludge retention
Albasi, Claire +3 more
core +1 more source