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Nitroimidazoles as Anti-Tumor Agents
Anti-Cancer Agents in Medicinal Chemistry, 2011At present cancer treatment is still a confusing problem. Great progress has been made in anti-tumor agents since a series of small molecules are approved by FDA as anti-tumor drugs. Nitroimidazoles is a kind of radiosensitizer with multiple bioactivities used in cancer treatment since 1950s.
Kai, Liu, Hai-Liang, Zhu
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Tinidazole: A nitroimidazole antiprotozoal agent
Clinical Therapeutics, 2005Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver ...
Horatio B, Fung, Thien-Ly, Doan
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Acta Crystallographica Section C Crystal Structure Communications, 1994
The molecules of the title compound, C 5 H 7 N 3 O 2 , are connected by bifurcated hydrogen bonds and form inifite chains along the b ...
T. A. Olszak +3 more
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The molecules of the title compound, C 5 H 7 N 3 O 2 , are connected by bifurcated hydrogen bonds and form inifite chains along the b ...
T. A. Olszak +3 more
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1982
The development in recent years of nitroimidazoles as chemotherapeutic agents has been extensive. The interest in this class of compounds apparently was raised in 1955 by the elucidation of the structure of the antibiotic Azomycin by Nakamura(l) and the discovery of the in vivo activity of 5-nitro-imidazoles against Trichomonas vaginalis(2). Since then
D. E. Schwartz, W. Hofheinz
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The development in recent years of nitroimidazoles as chemotherapeutic agents has been extensive. The interest in this class of compounds apparently was raised in 1955 by the elucidation of the structure of the antibiotic Azomycin by Nakamura(l) and the discovery of the in vivo activity of 5-nitro-imidazoles against Trichomonas vaginalis(2). Since then
D. E. Schwartz, W. Hofheinz
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Bioorganic & Medicinal Chemistry Letters, 2018
The success in exploring anti-tubercular potency of nitroimidazole and quinoline, the core moieties of recently approved anti-tubercular drugs instigated us to synthesize a series of alkylated/aminated 2-methyl-5-nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates and to evaluate them for their activities against Mycobacterium tuberculosis ...
, Shalini +3 more
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The success in exploring anti-tubercular potency of nitroimidazole and quinoline, the core moieties of recently approved anti-tubercular drugs instigated us to synthesize a series of alkylated/aminated 2-methyl-5-nitroimidazoles and nitroimidazole-7-chloroquinoline conjugates and to evaluate them for their activities against Mycobacterium tuberculosis ...
, Shalini +3 more
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Permeability of Nitroimidazoles in Rat Cortex
Chemotherapy, 1986The right cerebral hemisphere of the rat was perfused in situ by retrograde bolus infusion of some nitroimidazole drugs into the external carotid artery. The right jugular vein served to collect blood samples. Drugs were continuously measured in the right cortex by microvoltametric electrodes and in blood samples by high-performance liquid ...
A, Meulemans +4 more
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Antiparasitic Nitroimidazoles: 6. The Metabolism and Excretion of Some 2-Styryl-5-nitroimidazoles
Xenobiotica, 1973Abstract1. The metabolism and excretion of several 2-styryl-5-nitroimidazoles, which have shown interesting antiparasitic activity in laboratory animals, is described.2. Species differences have been observed in the formation of metabolites by oxidation of the alkyl group of the styryl nucleus.3.
D M, Morton, D M, Fuller, J N, Green
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Pharmacokinetics of Nitroimidazoles
1982In this paper I want to try and show how a knowledge of the metabolism and pharmacokinetics of a compound helps us to understand the reasons why it may or may not satisfy the criteria desired of a particular drug. How we want a drug to behave depends on the use we have in mind for it. For example, in Fig.
T. R. Marten +3 more
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On the mutagenicity of nitroimidazoles
Mutation Research/Reviews in Genetic Toxicology, 1981Regarding mutagenicity, metronidazole is one of the best-investigated compounds of the nitroimidazoles. This drug is mutagenic on bacteria, especially if base-pair tester strains are used and bacterial nitroreductases are present. The serum levels attained in man after intake of this drug are sufficient to cause mutations in bacteria.
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Modification of chemotherapy by nitroimidazoles
International Journal of Radiation Oncology*Biology*Physics, 1984The potentiation of chemotherapeutic agents by radiation sensitizers has been extensively studied for several years. There is little doubt that the effectiveness of certain anti-cancer drugs, primarily alkylating agents, can readily be enhanced both in vitro and in vivo through the addition of a sensitizer.
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